血清胰岛素生长因子-1和胶质纤维酸性蛋白在脑胶质瘤分级及预后评估中的临床价值_《华西医学》

作者：

张正保 ¹ , 覃川 ¹ , 晏怡 ² , 李柏成 ¹ , 张彪 ¹ , 胡建刚 ¹ ,  杨秀江 ¹

1 重庆大足区人民医院神经外科（重庆， 402360）;2 重庆医科大学附属第一医院神经外科;

关键词：

胰岛素生长因子-1 胶质纤维酸性蛋白肿瘤标志物脑胶质瘤临床价值

DOI：

10.7507/1002-0179.20130003

视频：

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摘要 全文 图表 视频 参考文献 施引文献 补充材料

目的　通过检测脑胶质瘤患者血清中胰岛素生长因子-1（IGF-1）和胶质纤维酸性蛋白（GFAP）的表达，探讨其与胶质瘤分级及预后评估的关系。方法　2010年12月－2011年11月，采用双抗体一步夹心法分别测定A、B两组共40例不同级别脑胶质瘤患者术前、术后血清中IGF-1和GFAP浓度。结果　高级别胶质瘤患者组血清中IGF-1浓度显著高于低级别胶质瘤组（P=0.009 0）；血清GFAP浓度显著低于低级别胶质瘤组（P＜0.000 1）。经手术治疗后且疗效评价为有效的胶质瘤患者，其血清中IGF-1、GFAP浓度较术前水平显著下降（P＜0.001 0）。结论　IGF-1、GFAP是两种较好的脑胶质瘤血清标志物，在其分级及预后评估中具有重要的临床应用价值。

引用本文： 张正保,覃川,晏怡,李柏成,张彪,胡建刚,杨秀江. 血清胰岛素生长因子-1和胶质纤维酸性蛋白在脑胶质瘤分级及预后评估中的临床价值. 华西医学, 2013, 28(1): 11-13. doi: 10.7507/1002-0179.20130003 复制

1.	Ferguson SD. Malignant gliomas: diagnosis and treatment[J]. Dis Mon, 2011, 57(10): 558-569.
2.	张玉林. 对神经系统肿瘤的国际分类的新观点[J]. 中国临床神经科学, 2001, 9(1): 105-108.
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4.	付锴, 袁先厚, 江普查, 等. HIF-1α, IGF-1在人脑胶质瘤中的表达及意义[J]. 现代肿瘤医学, 2005, 13(3): 317-319.
5.	Renehan AG, Zwahlen M, Minder C, et al. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis[J]. Lancet, 2004, 363(9418): 1346-1353.
6.	Godau J, Knauel K, Weber K, et al. Serum insulinlike growth factor 1 as possible marker for risk and early diagnosis of Parkinson disease[J]. Arch Neurol, 2011, 68(7): 925-931.
7.	Rohrmann S, Linseisen J, Becker S, et al. Concentrations of IGF-I and IGFBP-3 and brain tumor risk in the European Prospective Investigation into Cancer and Nutrition[J]. Cancer Epidemiol Biomarkers Prev, 2011, 20(10): 2174-2182.
8.	覃川, 黎成禄, 谢惠, 等. 胶质瘤患者血清IGF-1的表达及临床意义[J]. 重庆医学, 2009, 38(15): 1941-1942.
9.	陈忠平, 周旺宁. 我国胶质瘤诊断治疗现状和努力方向[J]. 中国肿瘤, 2005, 14(2): 78-81.
10.	Restrepo A, Smith CA, Agnihotri S, et al. Epigenetic regulation of glial fibrillary acidic protein by DNA methylation in human malignant gliomas[J]. Neuro Oncol, 2011, 13(1): 42-50.
11.	Peraud A, Mondal S, Hawkins C, et al. Expression of fascin, an actin-bundling protein, in astrocytomas of varying grades[J]. Brain Tumor Pathol, 2003, 20(2): 53-58.
12.	Brommeland T, Rosengren L, Fridlund S, et al. Serum levels of glial fibrillary acidic protein correlate to tumour volume of high-grade gliomas[J]. Acta Neurol Scand, 2007, 116(6): 380-384.
13.	Murakami M, Dirks PB, Hubbard SL, et al. Cytoskeletal-induced alterations in the adhesion of HT-1080 fibrosarcoma cells to extracellular matrix[J]. Int J Oncol, 2001, 18(5): 1027-1033.
14.	Yusubalieva GM, Baklaushev VP, Gurina OI, et al. Immunochemical analysis of glial fibrillary acidic protein as a tool to assess astroglial reaction in experimental C6 glioma[J]. Bull Exp Biol Med, 2010, 149(1): 125-130.
15.	Condorelli DF, Dell’albani P, Conticello SG, et al. A neural-specific hypomethylated domain in the 5’ flanking region of the glial fibrillary acidic protein gene[J]. Dev Neurosci, 1997, 19(5): 446-456.

1. 　Ferguson SD. Malignant gliomas: diagnosis and treatment[J]. Dis Mon, 2011, 57(10): 558-569.
2. 　张玉林. 对神经系统肿瘤的国际分类的新观点[J]. 中国临床神经科学, 2001, 9(1): 105-108.
3. 　Jo H, Jia Y, Subramanian KK, et al. Cancer cell-derived clusterin modulates the phosphatidylinositol 3’-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation[J]. Mol Cell Biol, 2008, 28(13): 4285-4299.
4. 　付锴, 袁先厚, 江普查, 等. HIF-1α, IGF-1在人脑胶质瘤中的表达及意义[J]. 现代肿瘤医学, 2005, 13(3): 317-319.
5. 　Renehan AG, Zwahlen M, Minder C, et al. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis[J]. Lancet, 2004, 363(9418): 1346-1353.
6. 　Godau J, Knauel K, Weber K, et al. Serum insulinlike growth factor 1 as possible marker for risk and early diagnosis of Parkinson disease[J]. Arch Neurol, 2011, 68(7): 925-931.
7. 　Rohrmann S, Linseisen J, Becker S, et al. Concentrations of IGF-I and IGFBP-3 and brain tumor risk in the European Prospective Investigation into Cancer and Nutrition[J]. Cancer Epidemiol Biomarkers Prev, 2011, 20(10): 2174-2182.
8. 　覃川, 黎成禄, 谢惠, 等. 胶质瘤患者血清IGF-1的表达及临床意义[J]. 重庆医学, 2009, 38(15): 1941-1942.
9. 　陈忠平, 周旺宁. 我国胶质瘤诊断治疗现状和努力方向[J]. 中国肿瘤, 2005, 14(2): 78-81.
10. 　Restrepo A, Smith CA, Agnihotri S, et al. Epigenetic regulation of glial fibrillary acidic protein by DNA methylation in human malignant gliomas[J]. Neuro Oncol, 2011, 13(1): 42-50.
11. 　Peraud A, Mondal S, Hawkins C, et al. Expression of fascin, an actin-bundling protein, in astrocytomas of varying grades[J]. Brain Tumor Pathol, 2003, 20(2): 53-58.
12. 　Brommeland T, Rosengren L, Fridlund S, et al. Serum levels of glial fibrillary acidic protein correlate to tumour volume of high-grade gliomas[J]. Acta Neurol Scand, 2007, 116(6): 380-384.
13. 　Murakami M, Dirks PB, Hubbard SL, et al. Cytoskeletal-induced alterations in the adhesion of HT-1080 fibrosarcoma cells to extracellular matrix[J]. Int J Oncol, 2001, 18(5): 1027-1033.
14. 　Yusubalieva GM, Baklaushev VP, Gurina OI, et al. Immunochemical analysis of glial fibrillary acidic protein as a tool to assess astroglial reaction in experimental C6 glioma[J]. Bull Exp Biol Med, 2010, 149(1): 125-130.
15. 　Condorelli DF, Dell’albani P, Conticello SG, et al. A neural-specific hypomethylated domain in the 5’ flanking region of the glial fibrillary acidic protein gene[J]. Dev Neurosci, 1997, 19(5): 446-456.

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血清胰岛素生长因子-1和胶质纤维酸性蛋白在脑胶质瘤分级及预后评估中的临床价值

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《华西医学》

血清胰岛素生长因子-1和胶质纤维酸性蛋白在脑胶质瘤分级及预后评估中的临床价值

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