创伤后应激障碍恢复力的研究进展_《华西医学》

作者：

何倩 ,  邓红

关键词：

创伤后应激障碍恢复力候选基因生物学机制遗传学研究

DOI：

10.7507/1002-0179.20130099

视频：

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摘要 全文 图表 视频 参考文献 施引文献 补充材料

个体在面临创伤性事件后是否发生创伤后应激障碍（PTSD）以及PTSD持续的时间与多种因素相关，可能有两方面决定个体的对创伤性事件的反应方向：一方面是发生PTSD的风险因素，另一方面是抵抗创伤性事件的反应和促进个体从创伤反应中恢复的恢复力。现对创伤抵抗与恢复起积极保护作用的恢复力的最新认识及其生物学机制和遗传学研究进行综述。

引用本文： 何倩,邓红. 创伤后应激障碍恢复力的研究进展. 华西医学, 2013, 28(2): 309-312. doi: 10.7507/1002-0179.20130099 复制

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12.	Mitra R, Adamec R, Sapolsky R, et al. Resilience against predator stress and dendritic morphology of amygdala neurons[J]. Behave Brain Res，2009, 205(2): 535-543.
13.	Koenen KC, Amstadter AB, Nugent NR, et al. Gene-environment interaction in posttraumatid stress disorder: an update[J]. J Trauma Stress, 2009, 22(15): 416-426.
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15.	Feder A, Nestler EJ, Charney DS, et al. Psychobiology and molecular genetics of resilience[J]. Nat Rev Neurosci, 2009, 10(6): 446-457.
16.	McEween BS, Milner TA. Hippocampal formation:shedding light on the influence of sex and stress on the brain[J]. Brain Res Rev, 2007, 55(2): 343-355.
17.	McGaugh JL. The amygdala modulates the consolidation of memories of emotionally arousing experiences[J]. Annu Rev Neurosci, 2004, 27(1): 1-28.
18.	Charney DS. Psychobiological mechanisms of resilience and vulnerability:implications for successful adaptation to extreme stress[J]. Am J Psychiatry, 2004, 161(3): 195-216.
19.	Sajdyk TJ, Shekhar A, Gehlert DR. Interactions between NPY and CRF in the amygdala to regulate emotionality[J]. Neuropeptides, 2004, 38(4): 225-234.
20.	Cohen H, Liu T, Kozlovsky N, et al. The neuropeptide Y (NPY)-ergic system is associated with behavioral resilience to stress exposure in an animal model of post-traumatic stress disorder[J]. Neuropsychopharmacol, 2012, 37(2): 350-363.
21.	Sajdyk TJ, Johnson PL, Leitermann RJ, et al. Neuropeptide Y in the amygdala induces long-term resilience to stress-induced reductions in social responses but not hypothalamic-adrenal-pituitary axis activity or hyperthermia[J]. J Neurosci, 2008, 28(4): 893-903.
22.	Duman RS, Monteggia LM. A neurotrophic model for stress-relate mood disorders[J]. Biol Psychiatry, 2006 , 59(12): 1116-1127.
23.	Bradley RG, Binder EB, Epstein MP, et al. Influence of child abuse on adult depression:moderation by the corticotropin-releasing hormone receptor gene[J]. Arch Gen Psychiatry, 2008, 65(2): 190-200.
24.	Gillespie CF, Phifer J, Bradley B,et al. Risk and resilience-genetic and environmental influences on development of the stress response[J]. Depress Anxiety, 2009, 26(11): 984-992.
25.	Suomi SJ. Risk, resilience, and gene x environment interactions in rhesus monkeys[J]. Ann N Y Acad Sci, 2006, 1094: 52-62.
26.	Marques Valente NL, Vallada H, Cordeiro Q, et al. Catechol-O-methyltransferase (COMT) val158met polymorphism as a risk factor for PTSD after urban violence[J]. J Mol Neurosci, 2011, 43(3) : 516-523.
27.	Chen ZY, Jing DQ, Bath KG,, et al. Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior[J]. Science, 2006, 314(5796): 140-143.
28.	Heinz A, Smolka MN. The effects of catechol O-methyltransferase genotype on brain activation elicited by affective stimuli and cognitive tasks[J]. Rev Neurosci, 2006, 17(3): 359-367.
29.	Adamec R, Toth M, Haller J, et al. A comparison of activation patterns of cells in selected prefrontal cortical and amygdala areas of rats which are more or less anxious in response to predator exposure or submersion stress[J]. Physiol Behav, 2012, 105(3): 628-638.

1. 　Ursano RJ, Zhang L, Li H, et al. PTSD and traumatic stress From gene to community and bench to bedside [J]. Brain Res, 2009, 1293(SI): 2-12.
2. 　Sederer LI. Are human made disasters different?[J]. Epidemiol Psychiatr Sci，2012, 21(1): 23-25.
3. 　deRoon-Cassini TA, Mancini AD, Rusch MD, et al. Psychopathology and resilience following traumatic injury:a latent growth mixture model analysis[J]. Rehabil, 2010, 55(1): 1-11.
4. 　Lutz W, Michael S, Milton K, et al. Dreaming in posttraumatic stress disorder: a critical review of phenomenology[J]. Psychother Psychosom, 2007, 76: 25-39.
5. 　Hobfoll SE, Johnson RJ, Canetti D, et al. Can people remain engaged and vigorous in the face of trauma? Palestinians in the West Bank and Gaza[J]. Psychiatry, 2012, 75(1): 60-75.
6. 　Feldman R, Vengrober A. Posttraumatic stress disorder in infants and young children exposed to war-related trauma[J]. J Am Acad Child Psy, 2011, 50(7): 645-658.
7. 　Richardson GE. The metatheory of resilience and resiliency[J]. J Clin Exp Neuropsyc. 2002, 58: 307-321.
8. 　Hunter AJ, Chandler GE. Adolescent resilience[J]. J Nurs Scholarship, 1999, 31(3): 243-247.
9. 　Bostock L, Sheikh AI, Barton S, et al. Posttraumatic growth and optimism in health-related trauma[J]. J Clin Psychol Med Setting, 2009, 16(4): 281-296.
10. 　Connor KM, Daavidson JK. Development of a new resilience scale: the connor-davidson resilience scale: the Connor-Davidson Resilience Resilience Scale (CD-RISC)[J]. Depr Anx, 2003, 18(2): 76-82.
11. 　于肖楠, 张建新.自我韧性量表与 Connor-Davidson韧性量表的应用比较[J]. 心理科学, 2007, 30(5): 1169-1171.
12. 　Mitra R, Adamec R, Sapolsky R, et al. Resilience against predator stress and dendritic morphology of amygdala neurons[J]. Behave Brain Res，2009, 205(2): 535-543.
13. 　Koenen KC, Amstadter AB, Nugent NR, et al. Gene-environment interaction in posttraumatid stress disorder: an update[J]. J Trauma Stress, 2009, 22(15): 416-426.
14. 　Liberzon I, Knox D. Expanding our understanding of neurobiological mechanisms of resilience by using animalmodels[J]. Neuro Psychopharmacol, 2012, 37(2): 317-318.
15. 　Feder A, Nestler EJ, Charney DS, et al. Psychobiology and molecular genetics of resilience[J]. Nat Rev Neurosci, 2009, 10(6): 446-457.
16. 　McEween BS, Milner TA. Hippocampal formation:shedding light on the influence of sex and stress on the brain[J]. Brain Res Rev, 2007, 55(2): 343-355.
17. 　McGaugh JL. The amygdala modulates the consolidation of memories of emotionally arousing experiences[J]. Annu Rev Neurosci, 2004, 27(1): 1-28.
18. 　Charney DS. Psychobiological mechanisms of resilience and vulnerability:implications for successful adaptation to extreme stress[J]. Am J Psychiatry, 2004, 161(3): 195-216.
19. 　Sajdyk TJ, Shekhar A, Gehlert DR. Interactions between NPY and CRF in the amygdala to regulate emotionality[J]. Neuropeptides, 2004, 38(4): 225-234.
20. 　Cohen H, Liu T, Kozlovsky N, et al. The neuropeptide Y (NPY)-ergic system is associated with behavioral resilience to stress exposure in an animal model of post-traumatic stress disorder[J]. Neuropsychopharmacol, 2012, 37(2): 350-363.
21. 　Sajdyk TJ, Johnson PL, Leitermann RJ, et al. Neuropeptide Y in the amygdala induces long-term resilience to stress-induced reductions in social responses but not hypothalamic-adrenal-pituitary axis activity or hyperthermia[J]. J Neurosci, 2008, 28(4): 893-903.
22. 　Duman RS, Monteggia LM. A neurotrophic model for stress-relate mood disorders[J]. Biol Psychiatry, 2006 , 59(12): 1116-1127.
23. 　Bradley RG, Binder EB, Epstein MP, et al. Influence of child abuse on adult depression:moderation by the corticotropin-releasing hormone receptor gene[J]. Arch Gen Psychiatry, 2008, 65(2): 190-200.
24. 　Gillespie CF, Phifer J, Bradley B,et al. Risk and resilience-genetic and environmental influences on development of the stress response[J]. Depress Anxiety, 2009, 26(11): 984-992.
25. 　Suomi SJ. Risk, resilience, and gene x environment interactions in rhesus monkeys[J]. Ann N Y Acad Sci, 2006, 1094: 52-62.
26. 　Marques Valente NL, Vallada H, Cordeiro Q, et al. Catechol-O-methyltransferase (COMT) val158met polymorphism as a risk factor for PTSD after urban violence[J]. J Mol Neurosci, 2011, 43(3) : 516-523.
27. 　Chen ZY, Jing DQ, Bath KG,, et al. Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior[J]. Science, 2006, 314(5796): 140-143.
28. 　Heinz A, Smolka MN. The effects of catechol O-methyltransferase genotype on brain activation elicited by affective stimuli and cognitive tasks[J]. Rev Neurosci, 2006, 17(3): 359-367.
29. 　Adamec R, Toth M, Haller J, et al. A comparison of activation patterns of cells in selected prefrontal cortical and amygdala areas of rats which are more or less anxious in response to predator exposure or submersion stress[J]. Physiol Behav, 2012, 105(3): 628-638.

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创伤后应激障碍恢复力的研究进展

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《华西医学》

创伤后应激障碍恢复力的研究进展

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