卵巢上皮性癌脑转移_《华西医学》

作者：

白莉平 , 王飞 , 褚艳侠 , 陈亚丽 ,  郑艾

四川大学华西第二医院妇产科（成都，610041）;

关键词：

卵巢上皮性癌脑转移发生率治疗预后

DOI：

10.7507/1002-0179.20130300

视频：

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摘要 全文 图表 视频 参考文献 施引文献 补充材料

卵巢上皮性癌（EOC）是妇科三大恶性肿瘤之一，其死亡率高。卵巢上皮性癌脑转移的发生率较低，但是其预后差，近年EOC的脑转移发生率有增高趋势。脑转移可通过患者的症状、体征、头颅CT、MRI等方法较易诊断。目前缺乏对卵巢上皮性癌脑转移的标准治疗方案。其治疗方法可选择手术、全脑放射治疗（WBRT）、立体定位放射治疗（SRS）、化学疗法，综合多种治疗方法效果优于单一治疗方式。

引用本文： 白莉平,王飞,褚艳侠,陈亚丽,郑艾. 卵巢上皮性癌脑转移. 华西医学, 2013, 28(6): 959-962. doi: 10.7507/1002-0179.20130300 复制

1.	Rebecca S, Deepa N, Ahmedin J. Cancer statistics, 2012[J]. CA Cancer J Clin, 2012, 62(1): 10-29.
2.	Barnholtz-Sloan Js, Schwartz Ag, Qureshi F, et al. Ovarian cancer: changes in patterns at diagnosis and relative survival over the last three decades[J]. Am J Obstet Gynecol, 2003, 189(4): 1120-1127.
3.	Chan JK, Zhang M, Hu JM, et al. Racial disparities in surgical treatment and survival of epithelial ovarian cancer in United States[J]. J Surg Oncol, 2008, 97(2): 103-107.
4.	Dale M, Larry J, Richard P, et al. Central nervous system metastases in epithelial ovarian carcinoma[J]. Obste Gyneco, 1986, 68(6): 746-750.
5.	Mayer RJ, Berkowitz RS, Griffiths CT. Central nervous system involvement by ovarian carcinoma. A complication of prolonged survival with metastatic disease[J]. Cancer, 1978, 41(2): 776-783.
6.	Pectasides D, Pectasides M, Economopoulos T. Brain metastases from epithelial ovarian cancer: a review of the literature[J]. Oncol, 2006, 11(3): 252-260.
7.	赵彦, 钱和年, 李蔚范, 等. 卵巢上皮性癌脑转移4例临床分析[J]. 中华妇产科杂志, 1999, 34(7): 420-422.
8.	Yang JX, Shen K, Shan Y, et al. Seven cases of epithelial ovarian carcinoma with brain metastasis[J]. Chin Med Sci J, 2008, 23(1): 19-22.
9.	单莹, 杨佳欣, 沈铿, 等. 卵巢上皮性癌脑转移7例临床分析及文献复习[J]. 中国肿瘤临床, 2008, 23(7): 375-377.
10.	马晓星, 李亚里, 胡凌云, 等. 卵巢癌脑转移的诊治[J]. J Chinese PLA Postgrad Med Sch Jun, 2012, 33(6): 583-585.
11.	Kolomainen DF, Larkin JM, Badran M, et al. epithelial ovarian cancer metastasizing to the brain: a late manifcstadon of the disease with an increasing incidence[J]. Clin Oncol, 2002, 20(4): 982-986.
12.	Chiang YC, Qiu JT, Chang CL , et al. Brain metastases from epithelial ovarian carcinoma: Evaluation of prognosis and managements-A Taiwanese Gynecologic Oncology Group (TGOG) Study[J]. Gyneco Onco, 2012, 125(1): 37-41.
13.	Elena SR, Eugene T, David MO, et al. Brain metastases in epithelial ovarian and primary peritoneal carcinoma[J]. Intern J Gynec Can, 2009, 19(5): 856-859.
14.	Kastritis E, Efstathiou E, Gika D, et al. Brain metastases as isolated site of relapse in patients with epithelial ovarian cancer previously treated with platinum and paclitaxel-based chemotherapy[J]. Int J Gynecol Can, 2006, 16( 3) : 994-999.
15.	Sehouli J, Pietzner K, Harter P, et al. Prognostic role of platinum sensitivity in patients with brain metastases from ovarian cancer: results of a German multicenter study[J]. Ann Onco, 2010, 21(11): 2201–2205.
16.	Chen YL, Cheng WF, Hsieh CY, et al. Brain metastasis as a late manifestation of ovarian carcinoma[J]. European Journal of Cancer Care, 2011, 20(1):44-49.
17.	Lee YK, Park NH, Kim JW, et al. Gamma-knife radiosurgery as an optimal treatment modality for brain metastases from epithelial ovarian cancer[J]. Gynecologic Oncology, 2008, 108(3): 505-509.
18.	Cormio G, Loizzi V, Falagario M, et al. Central nervous system metastases from epithelial ovarian cancer: prognostic factors and outcomes[J]. Inter J Gyneco Can, 2011, 21(5): 816-821.
19.	Cohen ZR, Suki D, Weinberg JS, et al. Brain metastases in patients with ovarian carcinoma: prognostic factors and outcome[J]. J Neurooncol, 2004, 66(3) : 313-325.
20.	Kaminsky-forrett MC, Weber B, Conroy T, et al. Brain metastases from epithelial ovarian carcinoma[J]. Int J Gynecol Can, 2000, 10(5): 366-371.
21.	Kumar L, Barge S, Mahapatra AK, et al. Central nervous system metastases from primary epithelial ovarian cancer[J]. Can Contr, 2003,10(3): 244-253.
22.	Sood A, Kumar L, Sood R, et al. Epithelial ovarian carcinoma metastatic to the central nervous system: a report on two cases with review of literature[J]. Gyneco Oncolo, 1996, 62(1): 113-118.
23.	Monaco E 3rd, Kondziolka D, Mongia S, et al. Management of Brain Metastases From Ovarian and Endometrial Carcinoma With Stereotactic Radiosurgery[J]. Ame Cancer Soc, 2008, 113(9): 2610-2614.
24.	Ogino A, Hirai T, Fukushima T, et al. Gamma knife surgery for brain metastases from ovarian cancer[J]. Acta Neurochir, 2012, 154(9): 1669-1677.
25.	Lee YK, Park NH, Kim JW, et al. Gamma-knife radiosurgery as an optimal treatment modality for brain metastases from epithelial ovarian cancer[J].Gynecologic Oncology, 2008, 108 (3): 505-509.
26.	Anupol N, Ghamande S, Odunsi K, et al. Evaluation of Prognostic Factors and Treatment Modalities in Ovarian Cancer Patients with Brain Metastases[J]. Gyneco Oncol, 2002, 85(3): 487-492.
27.	Cormio G, Maneo A, Colamaria A, et al. Surgical resection of solitary brain metastasis from ovarian carcinoma: an analysis of 22 cases[J]. Gyneco Oncol, 2003, 89(1): 116-119.
28.	Melichar B, Urminska H, Kohlova T, et al. Brain metastases of epithelial ovarian carcinoma responding to cisplatin and gemcitabine combination chemotherapy: a case report and review of the literature[J]. Gynecol Oncol, 2004, 94 (2): 267-276.
29.	Kodama M, Kawaguchi H, Komoto Y, et al. Coexistent intramedullary spinal cord and choroidal metastases in ovarian cancer[J]. J Obst Gynaecol Res, 2010, 36(1): 199-203.
30.	Cormio G, Gabriele A, Maneo A, et al. Complete remission of brain metastases from ovarian carcinoma with carboplatin[J]. Eur J Obstet Gynecol Reprod Biol, 1998, 78(1): 91-93.
31.	Watanabe A, Shimada M, Kigawa J, et al. The benefit of chemotherapy in a patient with multiple brain metastases and meningitis carcinomatosa from ovarian cancer[J]. Int J Clin Oncol, 2005, 10(1) : 69-71.
32.	Fortin D, Gendron C, Boudrias M, et al. Enhanced chemotherapy delivery by intraarterial infusion and blood-brain barrier disruption in the treatment of cerebral metastasis [J]. Cancer, 2007, 109(4): 751-760.
33.	Cormio G, Loizzi V, Falagario M, et al. Changes in the management and outcome of central nervous system involvement from ovarian cancer since 1994[J]. Int J Gynaecol Obstet, 2011, 114(2): 133-136.
34.	Rades D, Fischer D, Veninga T, et al. Prognostic factors for survival and intracerebral control after irradiation for brain metastases from gynecological cancer[J].Gynecol Oncol, 2009, 114(3): 506-508.
35.	Micha JP, Goldstein BH, Hunter JV, et al. Long-term survival in an ovarian cancer patient with brain metastases[J]. Gynecol Oncol, 2004, 92(3): 978-980.
36.	Matsuo K, Eno ML, Ahn EH, et al. Multidrug resistance gene (MDR-1) and risk of brain metastasis in epithelial ovarian, fallopian tube, and peritoneal cancer[J]. Ame J Clini Oncol, 2011, 34(5): 488-493.

1. 　Rebecca S, Deepa N, Ahmedin J. Cancer statistics, 2012[J]. CA Cancer J Clin, 2012, 62(1): 10-29.
2. 　Barnholtz-Sloan Js, Schwartz Ag, Qureshi F, et al. Ovarian cancer: changes in patterns at diagnosis and relative survival over the last three decades[J]. Am J Obstet Gynecol, 2003, 189(4): 1120-1127.
3. 　Chan JK, Zhang M, Hu JM, et al. Racial disparities in surgical treatment and survival of epithelial ovarian cancer in United States[J]. J Surg Oncol, 2008, 97(2): 103-107.
4. 　Dale M, Larry J, Richard P, et al. Central nervous system metastases in epithelial ovarian carcinoma[J]. Obste Gyneco, 1986, 68(6): 746-750.
5. 　Mayer RJ, Berkowitz RS, Griffiths CT. Central nervous system involvement by ovarian carcinoma. A complication of prolonged survival with metastatic disease[J]. Cancer, 1978, 41(2): 776-783.
6. 　Pectasides D, Pectasides M, Economopoulos T. Brain metastases from epithelial ovarian cancer: a review of the literature[J]. Oncol, 2006, 11(3): 252-260.
7. 　赵彦, 钱和年, 李蔚范, 等. 卵巢上皮性癌脑转移4例临床分析[J]. 中华妇产科杂志, 1999, 34(7): 420-422.
8. 　Yang JX, Shen K, Shan Y, et al. Seven cases of epithelial ovarian carcinoma with brain metastasis[J]. Chin Med Sci J, 2008, 23(1): 19-22.
9. 　单莹, 杨佳欣, 沈铿, 等. 卵巢上皮性癌脑转移7例临床分析及文献复习[J]. 中国肿瘤临床, 2008, 23(7): 375-377.
10. 　马晓星, 李亚里, 胡凌云, 等. 卵巢癌脑转移的诊治[J]. J Chinese PLA Postgrad Med Sch Jun, 2012, 33(6): 583-585.
11. 　Kolomainen DF, Larkin JM, Badran M, et al. epithelial ovarian cancer metastasizing to the brain: a late manifcstadon of the disease with an increasing incidence[J]. Clin Oncol, 2002, 20(4): 982-986.
12. 　Chiang YC, Qiu JT, Chang CL , et al. Brain metastases from epithelial ovarian carcinoma: Evaluation of prognosis and managements-A Taiwanese Gynecologic Oncology Group (TGOG) Study[J]. Gyneco Onco, 2012, 125(1): 37-41.
13. 　Elena SR, Eugene T, David MO, et al. Brain metastases in epithelial ovarian and primary peritoneal carcinoma[J]. Intern J Gynec Can, 2009, 19(5): 856-859.
14. 　Kastritis E, Efstathiou E, Gika D, et al. Brain metastases as isolated site of relapse in patients with epithelial ovarian cancer previously treated with platinum and paclitaxel-based chemotherapy[J]. Int J Gynecol Can, 2006, 16( 3) : 994-999.
15. 　Sehouli J, Pietzner K, Harter P, et al. Prognostic role of platinum sensitivity in patients with brain metastases from ovarian cancer: results of a German multicenter study[J]. Ann Onco, 2010, 21(11): 2201–2205.
16. 　Chen YL, Cheng WF, Hsieh CY, et al. Brain metastasis as a late manifestation of ovarian carcinoma[J]. European Journal of Cancer Care, 2011, 20(1):44-49.
17. 　Lee YK, Park NH, Kim JW, et al. Gamma-knife radiosurgery as an optimal treatment modality for brain metastases from epithelial ovarian cancer[J]. Gynecologic Oncology, 2008, 108(3): 505-509.
18. 　Cormio G, Loizzi V, Falagario M, et al. Central nervous system metastases from epithelial ovarian cancer: prognostic factors and outcomes[J]. Inter J Gyneco Can, 2011, 21(5): 816-821.
19. 　Cohen ZR, Suki D, Weinberg JS, et al. Brain metastases in patients with ovarian carcinoma: prognostic factors and outcome[J]. J Neurooncol, 2004, 66(3) : 313-325.
20. 　Kaminsky-forrett MC, Weber B, Conroy T, et al. Brain metastases from epithelial ovarian carcinoma[J]. Int J Gynecol Can, 2000, 10(5): 366-371.
21. 　Kumar L, Barge S, Mahapatra AK, et al. Central nervous system metastases from primary epithelial ovarian cancer[J]. Can Contr, 2003,10(3): 244-253.
22. 　Sood A, Kumar L, Sood R, et al. Epithelial ovarian carcinoma metastatic to the central nervous system: a report on two cases with review of literature[J]. Gyneco Oncolo, 1996, 62(1): 113-118.
23. 　Monaco E 3rd, Kondziolka D, Mongia S, et al. Management of Brain Metastases From Ovarian and Endometrial Carcinoma With Stereotactic Radiosurgery[J]. Ame Cancer Soc, 2008, 113(9): 2610-2614.
24. 　Ogino A, Hirai T, Fukushima T, et al. Gamma knife surgery for brain metastases from ovarian cancer[J]. Acta Neurochir, 2012, 154(9): 1669-1677.
25. 　Lee YK, Park NH, Kim JW, et al. Gamma-knife radiosurgery as an optimal treatment modality for brain metastases from epithelial ovarian cancer[J].Gynecologic Oncology, 2008, 108 (3): 505-509.
26. 　Anupol N, Ghamande S, Odunsi K, et al. Evaluation of Prognostic Factors and Treatment Modalities in Ovarian Cancer Patients with Brain Metastases[J]. Gyneco Oncol, 2002, 85(3): 487-492.
27. 　Cormio G, Maneo A, Colamaria A, et al. Surgical resection of solitary brain metastasis from ovarian carcinoma: an analysis of 22 cases[J]. Gyneco Oncol, 2003, 89(1): 116-119.
28. 　Melichar B, Urminska H, Kohlova T, et al. Brain metastases of epithelial ovarian carcinoma responding to cisplatin and gemcitabine combination chemotherapy: a case report and review of the literature[J]. Gynecol Oncol, 2004, 94 (2): 267-276.
29. 　Kodama M, Kawaguchi H, Komoto Y, et al. Coexistent intramedullary spinal cord and choroidal metastases in ovarian cancer[J]. J Obst Gynaecol Res, 2010, 36(1): 199-203.
30. 　Cormio G, Gabriele A, Maneo A, et al. Complete remission of brain metastases from ovarian carcinoma with carboplatin[J]. Eur J Obstet Gynecol Reprod Biol, 1998, 78(1): 91-93.
31. 　Watanabe A, Shimada M, Kigawa J, et al. The benefit of chemotherapy in a patient with multiple brain metastases and meningitis carcinomatosa from ovarian cancer[J]. Int J Clin Oncol, 2005, 10(1) : 69-71.
32. 　Fortin D, Gendron C, Boudrias M, et al. Enhanced chemotherapy delivery by intraarterial infusion and blood-brain barrier disruption in the treatment of cerebral metastasis [J]. Cancer, 2007, 109(4): 751-760.
33. 　Cormio G, Loizzi V, Falagario M, et al. Changes in the management and outcome of central nervous system involvement from ovarian cancer since 1994[J]. Int J Gynaecol Obstet, 2011, 114(2): 133-136.
34. 　Rades D, Fischer D, Veninga T, et al. Prognostic factors for survival and intracerebral control after irradiation for brain metastases from gynecological cancer[J].Gynecol Oncol, 2009, 114(3): 506-508.
35. 　Micha JP, Goldstein BH, Hunter JV, et al. Long-term survival in an ovarian cancer patient with brain metastases[J]. Gynecol Oncol, 2004, 92(3): 978-980.
36. 　Matsuo K, Eno ML, Ahn EH, et al. Multidrug resistance gene (MDR-1) and risk of brain metastasis in epithelial ovarian, fallopian tube, and peritoneal cancer[J]. Ame J Clini Oncol, 2011, 34(5): 488-493.

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卵巢上皮性癌脑转移

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《华西医学》

卵巢上皮性癌脑转移

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