正电子发射计算机断层显像/磁共振成像的临床应用新进展_《华西医学》

作者：

沈国华 , 周绿漪 , 贾志云 , 张文杰 , 王乔 ,  邓候富

四川大学华西医院核医学科（成都，610041）;

关键词：

正电子发射计算机断层显像磁共振成像分子影像学肿瘤学神经精神疾病多模式成像理

DOI：

10.7507/1002-0179.20130567

视频：

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摘要 全文 图表 视频 参考文献 施引文献 补充材料

正电子发射计算机断层显像/磁共振成像这一新型设备和技术的出现，不仅为肿瘤学、神经精神疾病等的临床应用开辟了新的道路，还为干细胞治疗等基础科研提供新的平台。它不简单是一种单一的技术变革，而是一种多模式成像理念的体现、多种技术的完美整合，它将给现代和将来的医学发展模式带来重大的影响。

引用本文： 沈国华,周绿漪,贾志云,张文杰,王乔,邓候富. 正电子发射计算机断层显像/磁共振成像的临床应用新进展. 华西医学, 2013, 28(11): 1787-1790. doi: 10.7507/1002-0179.20130567 复制

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22.	Catana C, Drzezga A, Heiss WD, et al. PET/MRI for neurologic applications[J]. J Nucl Med, 2012, 53(12): 1916-1925.
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26.	Lee WW, Marinelli B, van der Laan AM, et al. PET/MRI of inflammation in myocardial infarction[J]. J Am Coll Cardiol, 2012, 59(2): 153-163.
27.	Bjorklund LM, Sánchez-Pernaute R, Chung S, et al. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model[J]. Proc Natl Acad Sci USA, 2002, 99(4): 2344-2349.
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29.	王强, 王荣福. 当代最先进分子影像新技术——PET/MRI[J]. 中国医疗器械信息, 2011, 17(4): 4-7.
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1. 　Drzezga A, Souvatzoglou M, Eiber M, et al. First clinical experience with integrated whole-body PET/Mr: comparison to PET/CT in patients with oncologic diagnoses[J]. J Nucl Med, 2012, 53(6): 845-855.
2. 　Antoch G, Bockisch A. Combined PET/MRI: a new dimension in whole-body oncology imaging? [J]. Eur J Nucl Med Mol Imaging, 2009, 36 (Suppl 1): 113-120.
3. 　Buchbender C, Heusner TA, Lauenstein TC, et al. Oncologic PET/MRI, part 1: tumors of the brain, head and neck, chest, abdomen, and pelvis[J]. J Nucl Med, 2012, 53(6): 928-938.
4. 　Buchbender C, Heusner TA, Lauenstein TC, et al. Oncologic PET/MRI, part 2: bone tumors, soft-tissue tumors, melanoma, and lymphoma[J]. J Nucl Med, 2012, 53(8): 1244-1252.
5. 　Boss A, Stegger L, Bisdas S, et al. Feasibility of simultaneous PET/MR imaging in the head and upper neck area[J]. Eur Radiol, 2011, 21(7): 1439-1446.
6. 　Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation[J]. Cell, 2011, 144(5): 646-674.
7. 　Sauter AW, Wehrl HF, Kolb A, et al. Combined PET/MRI: one step further in multimodality imaging[J]. Trends Mol Med, 2010, 16(11): 508-515.
8. 　Ng TS, Bading JR, Park R, et al. Quantitative, simultaneous PET/MRI for intratumoral imaging with an MRI-compatible PET scanner[J]. J Nucl Med, 2012, 53(7): 1102-1109.
9. 　Schreiter NF, Nogami M, Steffen I, et al. Evaluation of the potential of PET-MRI fusion for detection of liver metastases in patients with neuroendocrine tumours[J]. Eur Radiol, 2012, 22(2): 458-467.
10. 　Nagarajah J, Jentzen W, Hartung V, et al. Diagnosis and dosimetry in differentiated thyroid carcinoma using 124I PET: comparison of PET/MRI vs PET/CT of the neck[J]. Eur J Nucl Med Mol Imaging, 2011, 38(10): 1862-1868.
11. 　Estorch M, Carrio I. Future challenges of multimodality imaging[J]. Recent Results Cancer Res, 2013, 187: 403-415.
12. 　Takasawa M, Jones PS, Guadagno JV, et al. How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET[J]. Stroke, 2008, 39(3): 870-877.
13. 　Guadagno JV, Warburton EA, Jones PS, et al. How affected is oxygen metabolism in DWI lesions? A combined acute stroke PET-MR study[J]. Neurology, 2006, 67(5): 824-829.
14. 　LoPinto-Khoury C, Sperling MR, Skidmore C, et al. Surgical outcome in PET-positive, MRI-negative patients with temporal lobe epilepsy[J]. Epilepsia, 2012, 53(2): 342-348.
15. 　Zaidi H, Del Guerra A. An outlook on future design of hybrid PET/MRI systems[J]. Med Phys, 2011, 38(10): 5667-5689.
16. 　Goffin K, Dedeurwaerdere S, Van Laere K, et al. Neuronuclear assessment of patients with epilepsy[J]. Semin Nucl Med, 2008, 38(4): 227-239.
17. 　Chen W, Silverman DH. Advances in evaluation of primary brain tumors[J]. Semin Nucl Med, 2008, 38(4): 240.
18. 　Gilman, S. Imaging the brain[J]. N Engl J Med, 1998, 338(12): 812-820.
19. 　Yakushev I, Fellgiebel A. Horizontal versus longitudinal axis of the hippocampus: metabolic differentiation as measured with high-resolution PET/MRI[J]. J Nucl Med, 2011, 52(2): 329-330.
20. 　Yakushev I, Müller MJ, Lorscheider M, et al. Increased hippocampal head diffusivity predicts impaired episodic memory performance in early Alzheimer’s disease[J]. Neuropsychologia, 2010, 48(5): 1447-1453.
21. 　Behera D, Jacobs KE, Behera S, et al. (18) F-FDG PET/MRI can be used to identify injured peripheral nerves in a model of neuropathic pain[J]. J Nucl Med, 2011, 52(8): 1308-1312.
22. 　Catana C, Drzezga A, Heiss WD, et al. PET/MRI for neurologic applications[J]. J Nucl Med, 2012, 53(12): 1916-1925.
23. 　Heiss WD, Raab P, Lanfermann H. Multimodality assessment of brain tumors and tumor recurrence[J]. J Nucl Med, 2011, 52(10): 1585-1600.
24. 　Nekolla SG, Martinez-Moeller A, Saraste A. PET and MRI in cardiac imaging: from validation studies to integrated applications[J]. Eur J Nucl Med Mol Imaging, 2009, 36 (Suppl 1): 121-130.
25. 　Majmudar MD, Nahrendorf M. Cardiovascular molecular imaging: the road ahead[J]. J Nucl Med, 2012, 53(5): 673-676.
26. 　Lee WW, Marinelli B, van der Laan AM, et al. PET/MRI of inflammation in myocardial infarction[J]. J Am Coll Cardiol, 2012, 59(2): 153-163.
27. 　Bjorklund LM, Sánchez-Pernaute R, Chung S, et al. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model[J]. Proc Natl Acad Sci USA, 2002, 99(4): 2344-2349.
28. 　Glaudemans AM, Quintero AM, Signore A. PET/MRI in infectious and inflammatory diseases: will it be a useful improvement?[J]. Eur J Nucl Med Mol Imaging, 2012, 39(5):745-749.
29. 　王强, 王荣福. 当代最先进分子影像新技术——PET/MRI[J]. 中国医疗器械信息, 2011, 17(4): 4-7.
30. 　许震生, 谭海波, 管一晖. PET/MRI研制进展及展望[J]. 中国医疗器械信息, 2011, 17(4): 1-3, 26.

《华西医学》

正电子发射计算机断层显像/磁共振成像的临床应用新进展

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《华西医学》

正电子发射计算机断层显像/磁共振成像的临床应用新进展

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