医用海藻酸基生物材料的研究进展_《中国修复重建外科杂志》

作者：

位晓娟 ^1,2 , 奚廷斐 ¹ , 顾其胜 ³ , 郑玉峰 ²

北京大学（北京，100871）1前沿交叉学科研究院，2工学院;;
3上海其胜生物材料技术研究所;

关键词：

海藻酸医用生物材料临床应用进展

DOI：

10.7507/1002-1892.20130220

视频：

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摘要 全文 图表 视频 参考文献 施引文献 补充材料

目的分析医用海藻酸基生物材料的研究现况，重点介绍其在临床领域的应用策略及研究进展，并讨论该材料在临床应用中需关注的重点问题。方法基于对国内外医用海藻酸基生物材料研究的广泛调研，并对国内外相关专利、文献、医药制品进行检索，综合分析其研发、应用现况，提出应重点关注的几个研究方向。结果医用海藻酸基生物材料已在临床广泛应用，知识产权方面也有多项专利，但集中于创伤敷料和齿科印模领域。心衰治疗、栓塞术、组织工程和干细胞培养作为较新的研究点有望成为该领域的发展新方向。结论医用海藻酸基生物材料新产品的开发具有良好的临床可行性和必要性，但作为新策略、新产品尚需进行大量的应用基础研究。

引用本文： 位晓娟,奚廷斐,顾其胜,郑玉峰. 医用海藻酸基生物材料的研究进展. 中国修复重建外科杂志, 2013, 27(8): 1015-1020. doi: 10.7507/1002-1892.20130220 复制

1.	Lee KY, Mooney DJ. Alginate: Properties and biomedical applications. Prog Polym Sci, 2012, 37(1): 106-126.
2.	Draget KI, SKjåk-Braek G, Smidsrød O. Alginate based new materials. Int J Biol Macromol, 1997, 21(1-2): 47-55.
3.	王清华, 钟文菲, 何盟. 藻酸盐敷料的临床应用: 与传统材料特征的比较. 中国组织工程研究与临床康复, 2010, 14(3): 533-536.
4.	Balakrishnan B, Mohanty M, Umashankar PR, et al. Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin. Biomaterials, 2005, 26(32): 6335-6342.
5.	范一木, 李涛, 焦德让, 等. APA介入显影栓塞剂治疗脑动静脉畸形. 生物医学工程与临床, 2003, 7(2): 94-96.
6.	郑江, 陈怡, 高亚辉, 等. 三种胶体材料及其复合物作为骨粘合剂的粘合强度比较. 中国海洋药物杂志, 2009, 28(1): 26-28.
7.	顾东风, 黄广勇, 何江, 等. 中国心力衰竭流行病学调查及其患病率. 中华心血管病杂志, 2003, 31(1): 3-6.
8.	Krum H, Abraham WT. Heart failure. Lancet, 2009, 373(9667): 941-955.
9.	Dahlmann J, Krause A, Möller L, et al. Fully defined in situ cross-linkable alginate and hyaluronic acid hydrogels for myocardial tissue engineering. Biomaterials, 2013, 34(4): 940-951.
10.	Landa N, Miller L, Feinberg MS, et al. Effect of injectable alginate implant on cardiac remodeling and function after recent and old infarcts in rat. Circulation, 2008, 117(1): 1388-1396.
11.	Leor J, Tuvia S, Guetta V, et al. Intracoronary injection of in situ forming alginate hydrogel reverse left ventricular remodeling after myocardial infarction in Swine. J Am Coll Cardiol, 2009, 54(11): 1014-1023.
12.	Oerlemans C, Seevinck PR, van de Maat GH, et al. Alginate-lanthanide microsphere for MRI-guided embolotherapy. Acta Biomater, 2013, 9(1): 4681-4687.
13.	Forster RE, Thürmer F, Wallrapp C, et al. Characterisation of physico-mechanical properties and degradation potential of calcium alginate beads for use in embolisation. J Mater Sci Mater Med, 2010, 21(7): 2243-2251.
14.	Lee KY, Peters MC, Mooney DJ. Comparison of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in SCID mice. J Control Release, 2003, 87(1-3): 49-56.
15.	Sun Q, Silva EA, Wang A, et al. Sustained release of multiple growth factors from injectable polymeric system as a novel therapeutic approach towards angiogenesis. Pharm Res, 2010, 27(2): 264-271.
16.	Hao X, Silva EA, Mansson-Broberg A, et al. Angiogenic effects of sequential release of VEGF-A165 and PDGF-BB with alginate hydrogels after myocardial infarction. Cardiovasc Res, 2007, 75(1): 178-185.
17.	Ruvinov E, Leor J, Cohen S. The promotion of myocardial repair by the sequential delivery of IGF-1 and HGF from an injectable alginate biomaterial in a model of acute myocardial infarction. Biomaterials, 2011, 32(2): 565-578.
18.	Jay SM, Shepherd BR, Andrejecsk JW, et al. Dual delivery of VEGF and MCP-1 to support endothelial cell transplantation for therapeutic vascularization. Biomaterials, 2010, 31(11): 3054-3062.
19.	Silva EA, Kim ES, Kong HJ, et al. Material-based deployment enhances efficacy of endothelial progenitor cells. Proc Natl Acad Sci U S A, 2008, 105(38): 14347-14352.
20.	Wang CC, Yang KC, Lin KH, et al. A highly organized three-dimensional alginate scaffold for cartilage tissue engineering prepared by microfluidic technology. Biomaterials, 2011, 32(29): 7118-7126.
21.	Wang CC, Yang KC, Lin KH, et al. Cartilage regeneration in SCID mice using a highly organized three-dimensional alginate scaffold. Biomaterials, 2012, 33(1): 120-127.
22.	Thornton AJ, Alsberg E, Albertelli M, et al. Shape-defining scaffolds for minimally invasive tissue engineering. Transplantation, 2004, 77(12): 1798-1803.
23.	黄永波, 卫小春, 翁习生, 等. 海藻酸钠-成年软骨细胞培养移植修复成年兔关节软骨缺损的研究. 中华实验外科杂志, 2004, 21(8): 988-990.
24.	朱振宗, 梁伟国, 沈雁, 等. 海藻酸钠复合载体长期培养软骨细胞的生物学稳定性. 中国组织工程研究与临床康复, 2011, 15(16): 2867-2870.
25.	Prang P, Müller R, Eljaouhari A, et al. The promotion of oriented axonal regrowth in the injured spinal cord by alginate-basedanisotropic capillary hydrogels. Biomaterials, 2006, 27(19): 3560-3569.
26.	Hashimoto T, Suzuki Y, Suzuki K, et al. Review: peripheral nerve regeneration using non-tubular alginate gel crosslinked with covalent bonds. J Mater Sci Mater Med, 2005, 16(6): 503-509.
27.	雄鹰, 王为, 于炜婷, 等. 微囊化雪旺细胞/神经组织移植促进周围神经再生的实验研究. 组织工程与重建外科杂志, 2005, 1(1): 18-21.
28.	汪大彬, 文益民, 蓝旭, 等. 壳聚糖-藻酸盐支架复合BMSCs修复急性脊髓损伤的实验研究. 中国修复重建外科杂志, 2010, 24(2): 190-195.
29.	任利玲, 冯雪, 马东洋, 等. 海藻酸盐小球中培养的软骨细胞的生长. 西安交通大学学报: 医学版, 2011, 32(1): 57-61.
30.	Rowley JA, Mooney DJ. Alginate type and RGD density control myoblast phenotype. J Biomed Mater Res, 2002, 60(2): 217-223.
31.	李彩荣, 凌斌. 间充质干细胞与肿瘤生物治疗. 国际肿瘤学杂志, 2011, 38(4): 254-256.
32.	那春鑫, 王彦红, 王麟, 等. 干细胞治疗糖尿病的研究进展. 生物医学工程学进展, 2010, 31(2): 110-113.
33.	姚立松, 刘天庆, 葛丹, 等. 海藻酸钙微胶珠培养神经干细胞研究. 中国生物医学工程学报, 2007, 26(1): 126-133.

1. Lee KY, Mooney DJ. Alginate: Properties and biomedical applications. Prog Polym Sci, 2012, 37(1): 106-126.
2. Draget KI, SKjåk-Braek G, Smidsrød O. Alginate based new materials. Int J Biol Macromol, 1997, 21(1-2): 47-55.
3. 王清华, 钟文菲, 何盟. 藻酸盐敷料的临床应用: 与传统材料特征的比较. 中国组织工程研究与临床康复, 2010, 14(3): 533-536.
4. Balakrishnan B, Mohanty M, Umashankar PR, et al. Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin. Biomaterials, 2005, 26(32): 6335-6342.
5. 范一木, 李涛, 焦德让, 等. APA介入显影栓塞剂治疗脑动静脉畸形. 生物医学工程与临床, 2003, 7(2): 94-96.
6. 郑江, 陈怡, 高亚辉, 等. 三种胶体材料及其复合物作为骨粘合剂的粘合强度比较. 中国海洋药物杂志, 2009, 28(1): 26-28.
7. 顾东风, 黄广勇, 何江, 等. 中国心力衰竭流行病学调查及其患病率. 中华心血管病杂志, 2003, 31(1): 3-6.
8. Krum H, Abraham WT. Heart failure. Lancet, 2009, 373(9667): 941-955.
9. Dahlmann J, Krause A, Möller L, et al. Fully defined in situ cross-linkable alginate and hyaluronic acid hydrogels for myocardial tissue engineering. Biomaterials, 2013, 34(4): 940-951.
10. Landa N, Miller L, Feinberg MS, et al. Effect of injectable alginate implant on cardiac remodeling and function after recent and old infarcts in rat. Circulation, 2008, 117(1): 1388-1396.
11. Leor J, Tuvia S, Guetta V, et al. Intracoronary injection of in situ forming alginate hydrogel reverse left ventricular remodeling after myocardial infarction in Swine. J Am Coll Cardiol, 2009, 54(11): 1014-1023.
12. Oerlemans C, Seevinck PR, van de Maat GH, et al. Alginate-lanthanide microsphere for MRI-guided embolotherapy. Acta Biomater, 2013, 9(1): 4681-4687.
13. Forster RE, Thürmer F, Wallrapp C, et al. Characterisation of physico-mechanical properties and degradation potential of calcium alginate beads for use in embolisation. J Mater Sci Mater Med, 2010, 21(7): 2243-2251.
14. Lee KY, Peters MC, Mooney DJ. Comparison of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in SCID mice. J Control Release, 2003, 87(1-3): 49-56.
15. Sun Q, Silva EA, Wang A, et al. Sustained release of multiple growth factors from injectable polymeric system as a novel therapeutic approach towards angiogenesis. Pharm Res, 2010, 27(2): 264-271.
16. Hao X, Silva EA, Mansson-Broberg A, et al. Angiogenic effects of sequential release of VEGF-A165 and PDGF-BB with alginate hydrogels after myocardial infarction. Cardiovasc Res, 2007, 75(1): 178-185.
17. Ruvinov E, Leor J, Cohen S. The promotion of myocardial repair by the sequential delivery of IGF-1 and HGF from an injectable alginate biomaterial in a model of acute myocardial infarction. Biomaterials, 2011, 32(2): 565-578.
18. Jay SM, Shepherd BR, Andrejecsk JW, et al. Dual delivery of VEGF and MCP-1 to support endothelial cell transplantation for therapeutic vascularization. Biomaterials, 2010, 31(11): 3054-3062.
19. Silva EA, Kim ES, Kong HJ, et al. Material-based deployment enhances efficacy of endothelial progenitor cells. Proc Natl Acad Sci U S A, 2008, 105(38): 14347-14352.
20. Wang CC, Yang KC, Lin KH, et al. A highly organized three-dimensional alginate scaffold for cartilage tissue engineering prepared by microfluidic technology. Biomaterials, 2011, 32(29): 7118-7126.
21. Wang CC, Yang KC, Lin KH, et al. Cartilage regeneration in SCID mice using a highly organized three-dimensional alginate scaffold. Biomaterials, 2012, 33(1): 120-127.
22. Thornton AJ, Alsberg E, Albertelli M, et al. Shape-defining scaffolds for minimally invasive tissue engineering. Transplantation, 2004, 77(12): 1798-1803.
23. 黄永波, 卫小春, 翁习生, 等. 海藻酸钠-成年软骨细胞培养移植修复成年兔关节软骨缺损的研究. 中华实验外科杂志, 2004, 21(8): 988-990.
24. 朱振宗, 梁伟国, 沈雁, 等. 海藻酸钠复合载体长期培养软骨细胞的生物学稳定性. 中国组织工程研究与临床康复, 2011, 15(16): 2867-2870.
25. Prang P, Müller R, Eljaouhari A, et al. The promotion of oriented axonal regrowth in the injured spinal cord by alginate-basedanisotropic capillary hydrogels. Biomaterials, 2006, 27(19): 3560-3569.
26. Hashimoto T, Suzuki Y, Suzuki K, et al. Review: peripheral nerve regeneration using non-tubular alginate gel crosslinked with covalent bonds. J Mater Sci Mater Med, 2005, 16(6): 503-509.
27. 雄鹰, 王为, 于炜婷, 等. 微囊化雪旺细胞/神经组织移植促进周围神经再生的实验研究. 组织工程与重建外科杂志, 2005, 1(1): 18-21.
28. 汪大彬, 文益民, 蓝旭, 等. 壳聚糖-藻酸盐支架复合BMSCs修复急性脊髓损伤的实验研究. 中国修复重建外科杂志, 2010, 24(2): 190-195.
29. 任利玲, 冯雪, 马东洋, 等. 海藻酸盐小球中培养的软骨细胞的生长. 西安交通大学学报: 医学版, 2011, 32(1): 57-61.
30. Rowley JA, Mooney DJ. Alginate type and RGD density control myoblast phenotype. J Biomed Mater Res, 2002, 60(2): 217-223.
31. 李彩荣, 凌斌. 间充质干细胞与肿瘤生物治疗. 国际肿瘤学杂志, 2011, 38(4): 254-256.
32. 那春鑫, 王彦红, 王麟, 等. 干细胞治疗糖尿病的研究进展. 生物医学工程学进展, 2010, 31(2): 110-113.
33. 姚立松, 刘天庆, 葛丹, 等. 海藻酸钙微胶珠培养神经干细胞研究. 中国生物医学工程学报, 2007, 26(1): 126-133.

《中国修复重建外科杂志》

医用海藻酸基生物材料的研究进展

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《中国修复重建外科杂志》

医用海藻酸基生物材料的研究进展

摘要 全文 图表 视频 参考文献 施引文献 补充材料

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