FLIC、SF-36和QOL-LC量表在肝癌患者生活质量测定中的应用比较_《中国循证医学杂志》

作者：

祝葆华 ¹ ,  万崇华 ² , 王坤 ¹ , 苑进凯 ¹ , 许传志 ³ , 孟琼 ³

1. 广东医学院第一临床学院（东莞 523808）；2. 广东医学院人文与管理学院暨生命质量与应用心理研究中心（东莞 523808）；3. 昆明医科大学公共卫生学院（昆明 650031）;

关键词：

肝癌生活质量评估 SF-36量表 QOL-LC量表 FLIC量表

DOI：

10.7507/1672-2531.20120184

视频：

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摘要 全文 图表 视频 参考文献 施引文献 补充材料

目的　比较癌症患者生活功能指标量表（FLIC）、健康调查简表（SF-36）和肝癌患者生活质量测定量表（QOL-LC）在肝癌患者生活质量测定中的应用效果。
方法　以2010～2011年选定的调查医院肝癌住院患者105例为研究对象，采用FLIC、SF-36和QOL-LC量表分别进行3次纵向测定，计算和比较各量表的信度、效度和反应度。
结果　QOL-LC的效度、信度比FLIC和SF-36量表好；在反应度方面，QOL-LC及FLIC量表均显示躯体功能与总生命质量的变化差异有统计学意义（QOL-LC：t=5.08；P=0.000；t=3.16；P=0.002；FLIC：t=4.02；P=0.000；t=2.21；P=0.030）。SF-36量表除一般健康状况和心理健康两个领域外，其余领域的治疗前后得分变化均有统计学意义（躯体功能t=5.94；P=0.000；躯体角色t=3.07；P=0.003；身体疼痛t=3.21；P=0.002；生命力t=3.22；P=0.002；社会角色t=2.60；P=0.012；情绪角色t=3.28；P=0.002）。
结论　QOL-LC是测定肝癌患者生活质量的特异量表，在评估肝癌患者生活质量时是首选，而SF-36和FLIC量表能反映肝癌患者生命质量的共性部分，在缺少特异性量表的情况下，可用于测评肝癌患者的生活质量。

引用本文： 祝葆华,万崇华,王坤,苑进凯,许传志,孟琼. FLIC、SF-36和QOL-LC量表在肝癌患者生活质量测定中的应用比较. 中国循证医学杂志, 2012, 12(10): 1175-1179. doi: 10.7507/1672-2531.20120184 复制

1.	Ware JE Jr, Gandek B. Overview of the SF-36 health survey and the international quality of life assessment(IQOLA)project. J Clin Epidemiol, 1998, 51(11): 903-912.
2.	万崇华, 方积乾, 汤学良, 等. SF-36量表用于肝癌患者生命质量测定的效果评价. 肿瘤, 2005, 25(5): 492-494.
3.	Sehipper H, Clinch J, McMurray A, et al. Measuring the quality of Life of cancer patients: the functional living index: development and validation. Journal of Clinical Oncology, 1984, 54(32): 472-483.
4.	万崇华, 方积乾, 张灿珍, 等. FLIC量表用于肝癌患者生命质量测定的对比研究. 中国行为医学科学, 2000, 9(5): 321-322.
5.	Wan C, Fang J, Yang Z, et al. Development and validation of a quality of life instrument for patients with liver cancer QOL-LC. Am J Clin Oncol, 2010, 33(5): 448-455.
6.	万崇华, 方积乾, 张灿珍, 等. 肝癌患者生活质量测定量表的制定与考评. 中国行为医学科学, 1998, 7(3): 170-172.
7.	Wan C, Fang J, Yang Z, et al. Development andvalidation of a quality of life instrument for patients with liver cancer QOL-LC. Am J Clin Oncol, 2010, 33(5): 448-455.
8.	Heffernan N, Cella D, Webster K, et al. Measuring Health-Related Quality of Life in Patients With Hepatobiliary Cancers: The Functional Assessment of Cancer Therapy–Hepatobiliary Questionnaire. Journal of Clinical Oncology, 2002, 20(9): 2229-2239.
9.	Hobson P, Bhowmick B, Meara J, et al. Use of the SF-36 questionnaire in cerebrovascular disease. Stroke, 1997, 28(2): 464-465.
10.	李薇, 戚艳波, 万崇华, 等. 癌症患者生命质量测定量表体系之肝癌量表QLICP-LI的条目筛选. 中国肿瘤, 2011, 20(10): 746-749.
11.	Wible BC, Rilling WS, Drescher P, et al. Longitudinal quality of life assessment of patients with hepatocellular carcinoma after primary transarterial chemoembolization. J Vasc Interv Radiol, 2010, 21(7): 1024-1030.
12.	Fan SY, Eiser C, Ho MC. Health-related quality of life in patients with hepatocellular carcinoma: a systematic review. Clin Gastroenterol Hepatol, 2010, 8(7): 559-564.
13.	Mikoshiba N, Tateishi R, Tanaka M, et al. Validation of the Japanese version of the EORTC hepatocellular carcinoma-specific quality of life questionnaire module (QLQ-HCC18). Health Qual Life Outcomes, 2012, 10(1): 58-63.
14.	Casanovas T, Jané L, Herdman M, et al. Assessing outcomes in liver disease patients: reliability and validity of the Spanish version of the Liver Disease Quality of Life Questionnaire (LDQOL 1.0). Value Health, 2010, 13(4): 455-462.
15.	Chie WC, Blazeby JM, Hsiao CF, et al. International cross-cultural field validation of an European Organization for Research and Treatment of Cancer questionnaire module for patients with primary liver cancer, the European Organization for Research and Treatment of Cancer quality-of-life questionnaire HCC18. Hepatology, 2012, 55(4): 1122-1129.

1. Ware JE Jr, Gandek B. Overview of the SF-36 health survey and the international quality of life assessment(IQOLA)project. J Clin Epidemiol, 1998, 51(11): 903-912.
2. 万崇华, 方积乾, 汤学良, 等. SF-36量表用于肝癌患者生命质量测定的效果评价. 肿瘤, 2005, 25(5): 492-494.
3. Sehipper H, Clinch J, McMurray A, et al. Measuring the quality of Life of cancer patients: the functional living index: development and validation. Journal of Clinical Oncology, 1984, 54(32): 472-483.
4. 万崇华, 方积乾, 张灿珍, 等. FLIC量表用于肝癌患者生命质量测定的对比研究. 中国行为医学科学, 2000, 9(5): 321-322.
5. Wan C, Fang J, Yang Z, et al. Development and validation of a quality of life instrument for patients with liver cancer QOL-LC. Am J Clin Oncol, 2010, 33(5): 448-455.
6. 万崇华, 方积乾, 张灿珍, 等. 肝癌患者生活质量测定量表的制定与考评. 中国行为医学科学, 1998, 7(3): 170-172.
7. Wan C, Fang J, Yang Z, et al. Development andvalidation of a quality of life instrument for patients with liver cancer QOL-LC. Am J Clin Oncol, 2010, 33(5): 448-455.
8. Heffernan N, Cella D, Webster K, et al. Measuring Health-Related Quality of Life in Patients With Hepatobiliary Cancers: The Functional Assessment of Cancer Therapy–Hepatobiliary Questionnaire. Journal of Clinical Oncology, 2002, 20(9): 2229-2239.
9. Hobson P, Bhowmick B, Meara J, et al. Use of the SF-36 questionnaire in cerebrovascular disease. Stroke, 1997, 28(2): 464-465.
10. 李薇, 戚艳波, 万崇华, 等. 癌症患者生命质量测定量表体系之肝癌量表QLICP-LI的条目筛选. 中国肿瘤, 2011, 20(10): 746-749.
11. Wible BC, Rilling WS, Drescher P, et al. Longitudinal quality of life assessment of patients with hepatocellular carcinoma after primary transarterial chemoembolization. J Vasc Interv Radiol, 2010, 21(7): 1024-1030.
12. Fan SY, Eiser C, Ho MC. Health-related quality of life in patients with hepatocellular carcinoma: a systematic review. Clin Gastroenterol Hepatol, 2010, 8(7): 559-564.
13. Mikoshiba N, Tateishi R, Tanaka M, et al. Validation of the Japanese version of the EORTC hepatocellular carcinoma-specific quality of life questionnaire module (QLQ-HCC18). Health Qual Life Outcomes, 2012, 10(1): 58-63.
14. Casanovas T, Jané L, Herdman M, et al. Assessing outcomes in liver disease patients: reliability and validity of the Spanish version of the Liver Disease Quality of Life Questionnaire (LDQOL 1.0). Value Health, 2010, 13(4): 455-462.
15. Chie WC, Blazeby JM, Hsiao CF, et al. International cross-cultural field validation of an European Organization for Research and Treatment of Cancer questionnaire module for patients with primary liver cancer, the European Organization for Research and Treatment of Cancer quality-of-life questionnaire HCC18. Hepatology, 2012, 55(4): 1122-1129.

《中国循证医学杂志》

FLIC、SF-36和QOL-LC量表在肝癌患者生活质量测定中的应用比较

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《中国循证医学杂志》

FLIC、SF-36和QOL-LC量表在肝癌患者生活质量测定中的应用比较

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