酒精干预对大（小）鼠缺血性卒中结局影响的系统评价_《中国循证医学杂志》

作者：

齐广伟 ¹ , 郑佳 ² ,  赵瑞波 ¹

1. 哈尔滨医科大学病理学教研室（哈尔滨 150081）；2. 哈尔滨医科大学营养与食品卫生学教研室（哈尔滨 150081）;

关键词：

酒精缺血性卒中脑缺血系统评价 Meta分析动物实验

DOI：

10.7507/1672-2531.20130035

视频：

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摘要 全文 图表 视频 参考文献 施引文献 补充材料

目的　系统评价酒精干预对大（小）鼠缺血性卒中结局的影响。
方法　计算机检索PubMed、EMbase、BIOSIS、CNKI、WanFang Data和VIP数据库中关于酒精干预用于缺血性卒中动物模型的研究，检索时间截至2012年6月。按纳入与排除标准筛选文献、提取资料和进行方法学质量评价后，采用RevMan 5.1软件进行Meta分析。
结果　共纳入8个研究。Meta分析结果显示：与对照组相比，酒精干预组对缺血性卒中的影响无统计学意义［MD= –6.98%，95%CI（–20.38%，6.43%），P=0.31］，但低剂量急性酒精干预（≤2 g/kg）可改善缺血性卒中预后［MD= –22.83%，95%CI（–38.77%，–6.89%），P=0.005］，而高浓度慢性酒精干预会加重缺血性卒中脑缺血损伤［MD=24.06%，95%CI（10.54%，37.58%），P=0.000 5］。
结论　低剂量酒精干预对大（小）鼠具有潜在的神经保护作用，高剂量酒精干预则可能加重其脑损伤程度。但应注意，受纳入研究发表偏倚等因素的影响，酒精干预对大（小）鼠卒中结局的影响程度可能被高估。

引用本文： 齐广伟,郑佳,赵瑞波. 酒精干预对大（小）鼠缺血性卒中结局影响的系统评价. 中国循证医学杂志, 2013, 13(2): 204-209. doi: 10.7507/1672-2531.20130035 复制

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12.	Mandybur TI, Mendenhall CL. The effects of chronic alcoholism on development of ischemic cerebral infarcts following unilateral carotid artery ligation in gerbils. Alcohol Clin Exp Res, 1983, 7(4): 357-361.
13.	Zhao YJ, Yang GY, Domino EF. Acute ethanol effects on focal cerebral ischemia in nonfasted rats. Alcohol Clin Exp Res, 1997, 21(4): 745-748.
14.	Zhao YJ, Yang GY, Ben-Joseph O, et al. Acute ethanol effects on focal cerebral ischemia in fasted rats. Alcohol Clin Exp Res, 1998, 22(3): 717-722.
15.	Qi SH, Liu Y, Wang WW, et al. Neuroprotection of ethanol against cerebral ischemia/reperfusion induced brain injury through GABA receptor activation. Brain Res, 2009, 1276: 151-158.
16.	Qi SH, Liu Y, Hao LY, et al. Neuroprotection of ethanol against ischemia/reperfusion -induced brain injury through decreasing c-Jun N-terminal kinase 3 (JNK3) activation by enhancing GABA release. Neuroscience, 2010, 167(4): 1125-1137.
17.	Zeng X, Asmaro K, Ren C, et al. Acute ethanol treatment reduces blood-brain barrier dysfunction following ischemia/reperfusion injury. Brain Res, 2012, 1437: 127-133.
18.	Sena E, van der Worp HB, Howells D, et al. How can we improve the pre-clinical development of drugs for stroke? Trends Neurosci, 2007, 30(9): 433-439.
19.	Macleod MR, O’Collins T, Horky LL, et al. FK506对实验性卒中疗效的系统评价和Meta分析. 中国循证医学杂志, 2006, 6(5): 430-434.

1. Patra J, Taylor B, Irving H, et al. Alcohol consumption and the risk of morbidity and mortality for different stroke types–a systematic review and meta-analysis. BMC Public Health, 2010, 10: 258.
2. Macleod MR, O’Collins T, Howells DW, et al. Pooling of animal experimental data reveals influence of study design and publication bias. Stroke, 2004, 35(5):1203-1208.
3. MacDougall NJ, Muir KW. Hyperglycaemia and infarct size in animal models of middle cerebral artery occlusion: systematic review and meta-analysis. J Cereb Blood Flow Metab, 2011, 31(3): 807-818.
4. Crews FT, Steck JC, Chandler LJ, et al. Ethanol, stroke, brain damage, and excitotoxicity. Pharmacol Biochem Behav, 1998, 59(4): 981-991.
5. Zhao H, Mayhan WG, Arrick DM, et al. Dose-related influence of chronic alcohol consumption on cerebral ischemia/reperfusion injury. Alcohol Clin Exp Res, 2011, 35(7): 1265-1269.
6. Phillis JW, Estevez AY, O’Regan MH. Protective effects of the free radical scavengers, dimethyl sulfoxide and ethanol, in cerebral ischemia in gerbils. Neurosci Lett, 1998, 244(2): 109-111.
7. Masoero E, Frattini P, Favalli L, et al. Effect of acute alcohol on ischemia-induced glutamate release and brain damage. Alcohol, 2000, 22(3): 173-177.
8. Strong R, Grotta JC, Aronowski J. Combination of low dose ethanol and caffeine protects brain from damage produced by focal ischemia in rats. Neuropharmacology, 2000, 39(3): 515-522.
9. Wang F, Wang Y, Geng X, et al. Neuroprotective effect of acute ethanol administration in a rat with transient cerebral ischemia. Stroke, 2012, 43(1): 205-210.
10. Wang Q, Sun AY, Simonyi A, et al. Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: role of NADPH oxidase-derived ROS. Free Radic Biol Med, 2007, 43(7): 1048-1060.
11. Zhao H, Mayhan WG, Arrick DM, et al. Alcohol-induced exacerbation of ischemic brain injury: role of NAD(P)H oxidase. Alcohol Clin Exp Res, 2010, 34(11): 1948-1955.
12. Mandybur TI, Mendenhall CL. The effects of chronic alcoholism on development of ischemic cerebral infarcts following unilateral carotid artery ligation in gerbils. Alcohol Clin Exp Res, 1983, 7(4): 357-361.
13. Zhao YJ, Yang GY, Domino EF. Acute ethanol effects on focal cerebral ischemia in nonfasted rats. Alcohol Clin Exp Res, 1997, 21(4): 745-748.
14. Zhao YJ, Yang GY, Ben-Joseph O, et al. Acute ethanol effects on focal cerebral ischemia in fasted rats. Alcohol Clin Exp Res, 1998, 22(3): 717-722.
15. Qi SH, Liu Y, Wang WW, et al. Neuroprotection of ethanol against cerebral ischemia/reperfusion induced brain injury through GABA receptor activation. Brain Res, 2009, 1276: 151-158.
16. Qi SH, Liu Y, Hao LY, et al. Neuroprotection of ethanol against ischemia/reperfusion -induced brain injury through decreasing c-Jun N-terminal kinase 3 (JNK3) activation by enhancing GABA release. Neuroscience, 2010, 167(4): 1125-1137.
17. Zeng X, Asmaro K, Ren C, et al. Acute ethanol treatment reduces blood-brain barrier dysfunction following ischemia/reperfusion injury. Brain Res, 2012, 1437: 127-133.
18. Sena E, van der Worp HB, Howells D, et al. How can we improve the pre-clinical development of drugs for stroke? Trends Neurosci, 2007, 30(9): 433-439.
19. Macleod MR, O’Collins T, Horky LL, et al. FK506对实验性卒中疗效的系统评价和Meta分析. 中国循证医学杂志, 2006, 6(5): 430-434.

《中国循证医学杂志》

酒精干预对大（小）鼠缺血性卒中结局影响的系统评价

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《中国循证医学杂志》

酒精干预对大（小）鼠缺血性卒中结局影响的系统评价

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