HLA-G基因14 bp插入/缺失多态性与子痫前期相关性的Meta分析_《中国循证医学杂志》

作者：

沈彦婷 ¹ ,  于红 ¹ , 王蓓 ²

1. 东南大学附属中大医院妇产科（南京 210009）；2. 东南大学公共卫生学院（南京 210009）;

关键词：

子痫前期 HLA-G 多态性系统评价 Meta分析病例-对照研究

DOI：

10.7507/1672-2531.20130167

视频：

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摘要 全文 图表 视频 参考文献 施引文献 补充材料

目的　系统评价HLA-G基因3’非编码区14 bp插入/缺失多态性与子痫前期的相关性。
方法　计算机检索PubMed、Web of Science、EMbase、CBM、CNKI、WanFang Data、VIP，收集2012年5月以前国内外公开发表的有关妊娠妇女及其配偶、后代HLA-G 14 bp插入/缺失多态性与子痫前期相关性的病例-对照研究。由两位研究者按照纳入与排除标准独立筛选文献、提取资料和评价质量后，采用RevMan 5.1软件进行Meta分析。
结果　最终纳入10篇文献。Meta分析结果显示：子痫前期组父亲与子代的HLA-G+14 bp基因单倍型频率以及父亲+14 bp/+14 bp基因型频率明显高于正常对照组，子代HLA-G −14 bp基因单倍型频率低于正常妊娠组。其合并OR值及其95%CI分别为1.42（1.10，1.84）、1.54（1.25，1.90）、2.00（1.19，3.38）、0.67（0.54，0.82）。子痫前期组子代+14 bp/+14 bp基因型频率明显高于正常对照组，−14 bp/−14 bp基因型频率明显低于正常对照组［OR=1.75，95%CI（1.11，2.77）；OR=0.57，95%CI（0.41，0.81）］。子痫前期组，母（−14 bp/−14 bp）/子（−14 bp/−14 bp）基因型配伍频率显著低于正常妊娠组［OR=0.52；95%CI（0.31，0.85）］，而母（+14 bp/−14 bp）/子（+14 bp/+14 bp）基因型配伍频率显著高于正常妊娠组［OR=3.77；95%CI（1.40，10.11）］；父（−14 bp/−14 bp）/子（−14 bp/−14 bp）基因型配伍频率显著低于正常妊娠组［OR=0.33，95%CI（0.15，0.75）］。
结论　父亲和子代HLA-G 14 bp插入/缺失多态性与子痫前期存在相关性，母子基因型配伍分析可为子痫前期病因研究与临床诊治提供新线索。

引用本文： 沈彦婷,于红,王蓓. HLA-G基因14 bp插入/缺失多态性与子痫前期相关性的Meta分析. 中国循证医学杂志, 2013, 13(8): 955-962. doi: 10.7507/1672-2531.20130167 复制

1.	Walker JJ. Preeclampsia. The Lancet, 2000, 356(9237): 1260-1265.
2.	Murphy DJ, Striate GM. Mortality and morbidity associated with early onset preeclampsia. Hypertens Pregnancy, 2000, 19(2): 221.
3.	李泽均, 刘兴会, 何国琳, 等. 重度子痫前期早产与自发性早产母儿结局的比较研究. 中国循证医学杂志, 2010, 10(9): 1016-1022.
4.	Hviid TV. HLA-G in human reproduction:Aspects of genetics, function and pregnancy complications. Hum Repmd Update, 2006, 12(3): 2.
5.	丰有吉, 主编. 妇产科学. 第七版. 北京: 人民卫生出版社, 2005: 74-84.
6.	Ownby RL, Crocco E, Acevedo A, et al. Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry, 2006, 63(5): 530-538.
7.	Zhang Z, Li Y, Zhang LL, et al. Association of 14 bp insertion/deletion polymorphism of the HLA-G gene in father with severe preeclampsia in Chinese. Tissue Antigens, 2012, 80(2): 158-164.
8.	Iversen AC, Nguyen OTD, Tømmerdal LF, et al. The HLA-G 14 bp gene polymorphism and decidual HLA-G14 bp gene expression in pre-eclamptic and normal pregnancies. Journal of Reproductive Immunology, 2008, 78(2): 158-165.
9.	Vianna P, Dalmaz CA, Veit TD, et al. Immunogenetics of pregnancy: Role of a 14-bp deletion in the maternal HLA-G gene in primiparous pre-eclamptic Brazilian women. Human Immunology, 2007, 68(8), 668-674.
10.	Lin A, Yan WH, Dai MZ, et al. Maternal human leukocyte antigen-G polymorphism is not associated with pre-eclampsia in a Chinese Han population. Tissue Antigens, 2008, 68(4): 311-316.
11.	Hylenius S, Andersen AMN, Melbye M, et al. Association between HLA-G genotype and risk of preeclampsia: a case±control study using family triads. Molecular Human Reproduction, 2004, 10(4): 237-246.
12.	Bermingham J, Jenkins D, McCarthy T, et al. Genetic analysis of insulin-like growth factor II and HLA-G in pre-eclampsia. Biochemical Society Transactions, 2000, 28(2): 215-219.
13.	Humphrey KE, Harrison GA, Cooper DW, et al. HLA-G deletion polymorphism and preeclampsia/ eclampsia. British Journal of Obstetrics and Gynaecology, 1995, 102(9): 707-710.
14.	张展, 李莹, 张琳琳, 等. 父源性 HLA-G基因14 bp缺失多态性与早发型重度子痫前期的相关性研究. 中国妇幼保健, 2012, 27(11): 1710-1713.
15.	李红, 张琳琳, 贾莉婷, 等. 母儿中HLA-G 14 bp插人／缺失多态性在早发型、晚发型重度子痫前期和正常妊娠中分布的差异.现代妇产科进展, 2011, 20(3): 203-206.
16.	张展, 王婧彦, 张琳琳, 等. 人类白细胞抗原G基因14 bp缺失多态性与重度子痫前期发病的关系. 中华妇产科杂志, 2010, 45(5): 348-352.
17.	Ahn H, Park J, Gilman-Sachs A, et al. Immunologic Characteristics of Preeclampsia, a Comprehensive Review. Am J Reprod Immunol, 2011, 65(4): 377-394.
18.	Servitje EL, Lopez NG, Olson DM. An immunological insight into the origins of preeclampsia. Hum Reprod Update, 2010, 16(5): 510-524.
19.	Uzan J, Carbonne M, Piconne O, et al. Pre-eclampsia: pathophysiology, diagnosis,and management. Vasc Health Risk Manag, 2011, 7: 467-474.
20.	Servitje EL, Lopez NG, Olson DM. An immunological insight into the origins of preeclampsia. Hum Reprod Update, 2010, 16(5): 510-524.
21.	Favier B, LeMaoult J, Lesport E, et al. ILT2/HLA-G interaction impairs NK-cell functions through the inhibition of the late but not the early events of the NK-cell activating synapse. Faseb J, 2010, 24(3): 689–699.

1. Walker JJ. Preeclampsia. The Lancet, 2000, 356(9237): 1260-1265.
2. Murphy DJ, Striate GM. Mortality and morbidity associated with early onset preeclampsia. Hypertens Pregnancy, 2000, 19(2): 221.
3. 李泽均, 刘兴会, 何国琳, 等. 重度子痫前期早产与自发性早产母儿结局的比较研究. 中国循证医学杂志, 2010, 10(9): 1016-1022.
4. Hviid TV. HLA-G in human reproduction:Aspects of genetics, function and pregnancy complications. Hum Repmd Update, 2006, 12(3): 2.
5. 丰有吉, 主编. 妇产科学. 第七版. 北京: 人民卫生出版社, 2005: 74-84.
6. Ownby RL, Crocco E, Acevedo A, et al. Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry, 2006, 63(5): 530-538.
7. Zhang Z, Li Y, Zhang LL, et al. Association of 14 bp insertion/deletion polymorphism of the HLA-G gene in father with severe preeclampsia in Chinese. Tissue Antigens, 2012, 80(2): 158-164.
8. Iversen AC, Nguyen OTD, Tømmerdal LF, et al. The HLA-G 14 bp gene polymorphism and decidual HLA-G14 bp gene expression in pre-eclamptic and normal pregnancies. Journal of Reproductive Immunology, 2008, 78(2): 158-165.
9. Vianna P, Dalmaz CA, Veit TD, et al. Immunogenetics of pregnancy: Role of a 14-bp deletion in the maternal HLA-G gene in primiparous pre-eclamptic Brazilian women. Human Immunology, 2007, 68(8), 668-674.
10. Lin A, Yan WH, Dai MZ, et al. Maternal human leukocyte antigen-G polymorphism is not associated with pre-eclampsia in a Chinese Han population. Tissue Antigens, 2008, 68(4): 311-316.
11. Hylenius S, Andersen AMN, Melbye M, et al. Association between HLA-G genotype and risk of preeclampsia: a case±control study using family triads. Molecular Human Reproduction, 2004, 10(4): 237-246.
12. Bermingham J, Jenkins D, McCarthy T, et al. Genetic analysis of insulin-like growth factor II and HLA-G in pre-eclampsia. Biochemical Society Transactions, 2000, 28(2): 215-219.
13. Humphrey KE, Harrison GA, Cooper DW, et al. HLA-G deletion polymorphism and preeclampsia/ eclampsia. British Journal of Obstetrics and Gynaecology, 1995, 102(9): 707-710.
14. 张展, 李莹, 张琳琳, 等. 父源性 HLA-G基因14 bp缺失多态性与早发型重度子痫前期的相关性研究. 中国妇幼保健, 2012, 27(11): 1710-1713.
15. 李红, 张琳琳, 贾莉婷, 等. 母儿中HLA-G 14 bp插人／缺失多态性在早发型、晚发型重度子痫前期和正常妊娠中分布的差异.现代妇产科进展, 2011, 20(3): 203-206.
16. 张展, 王婧彦, 张琳琳, 等. 人类白细胞抗原G基因14 bp缺失多态性与重度子痫前期发病的关系. 中华妇产科杂志, 2010, 45(5): 348-352.
17. Ahn H, Park J, Gilman-Sachs A, et al. Immunologic Characteristics of Preeclampsia, a Comprehensive Review. Am J Reprod Immunol, 2011, 65(4): 377-394.
18. Servitje EL, Lopez NG, Olson DM. An immunological insight into the origins of preeclampsia. Hum Reprod Update, 2010, 16(5): 510-524.
19. Uzan J, Carbonne M, Piconne O, et al. Pre-eclampsia: pathophysiology, diagnosis,and management. Vasc Health Risk Manag, 2011, 7: 467-474.
20. Servitje EL, Lopez NG, Olson DM. An immunological insight into the origins of preeclampsia. Hum Reprod Update, 2010, 16(5): 510-524.
21. Favier B, LeMaoult J, Lesport E, et al. ILT2/HLA-G interaction impairs NK-cell functions through the inhibition of the late but not the early events of the NK-cell activating synapse. Faseb J, 2010, 24(3): 689–699.

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HLA-G基因14 bp插入/缺失多态性与子痫前期相关性的Meta分析

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《中国循证医学杂志》

HLA-G基因14 bp插入/缺失多态性与子痫前期相关性的Meta分析

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