• 四川大學華西醫(yī)院風濕免疫科（成都，610041）;

引用本文： 劉源,石桂秀. 骨關節(jié)炎的藥物治療進展. 華西醫(yī)學, 2012, 27(12): 1761-1763. doi: 復制

1. 　Felson DT, Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention[J]. Arthritis Rheum, 1998, 41(8): 1343-1355.
2. 　徐苓, Michael CN, Zhang YQ, et al. 北京城區(qū)老年人膝、髖和手骨關節(jié)炎的患病率及其與美國白人患病率的比較研究[J]. 中華醫(yī)學雜志, 2003, 83(14): 1206-1209.
3. 　Towheed TE, Maxwell L, Judd MG, et al. Acetaminophen for osteoarthritis[J]. Cochrane Database Syst Rev, 2006(1): CD004257.
4. 　Schnitzer TJ, American College of Rheumatology. Update of ACR guidelines for osteoarthritis: role of the coxibs[J]. J Pain Symptom Manage, 2002, 23(4 Suppl): S24-S30.
5. 　Hochberg MC, Altman RD, April KT, et al. American college of rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee[J]. Arthritis Care Res (Hoboken), 2012, 64(4): 465-474.
6. 　Langman MJ, Jensen DM, Watson DJ, et al. Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs[J]. JAMA, 1999, 282(20): 1929-1933.
7. 　Anon. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines[J]. Arthritis Rheum, 2000, 43(9): 1905-1915.
8. 　Anon. The management of chronic pain in older persons: AGS Panel on Chronic Pain in Older Persons. American Geriatrics Society[J]. J Am Geriatr Soc, 1998, 46(5): 635-651.
9. 　Biswal S, Medhi B, Pandhi P. Longterm efficacy of topical nonsteroidal antiinflammatory drugs in knee osteoarthritis: metaanalysis of randomized placebo controlled clinical trials[J]. J Rheumatol, 2006, 33(9): 1841-1844.
10. 　Lin J, Zhang W, Jones A, et al. Efficacy of topical non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomised controlled trials[J]. BMJ, 2004, 329(7461): 324.
11. 　Zhang WY, Li Wan Po A. The effectiveness of topically applied capsaicin. A meta-analysis[J]. Eur J Clin Pharmacol, 1994, 46(6): 517-522.
12. 　Pelletier JP, Martel-Pelletier J. Therapeutic targets in osteoarthritis: from today to tomorrow with new imaging technology[J]. Ann Rheum Dis, 2003, 62(Suppl 2): ii79-ii82.
13. 　Richy F, Bruyere O, Ethgen O, et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis[J]. Arch Intern Med, 2003, 163(13): 1514-1522.
14. 　Durmus D, Alayli G, Aliyazicioglu Y, et al. Effects of glucosamine sulfate and exercise therapy on serum leptin levels in patients with knee osteoarthritis: preliminary results of randomized controlled clinical trial[J/OL]. Rheumatol Int, 2012. [2012-11-01]. http://link.springer.com/content/pdf/10.1007%2Fs00296-012-2401-9.
15. 　Bruyere O, Pavelka K, Rovati LC, et al. Total joint replacement after glucosamine sulphate treatment in knee osteoarthritis: results of a mean 8-year observation of patients from two previous 3-year, randomised, placebo-controlled trials[J]. Osteoarthritis Cartilage, 2008, 16(2): 254-260.
16. 　Mcalindon TE, Lavalley MP, Gulin JP, et al. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis[J]. JAMA, 2000, 283(11): 1469-1475.
17. 　Bellamy N, Campbell J, Robinson V, et al. Intraarticular corticosteroid for treatment of osteoarthritis of the knee[J]. Cochrane Database Syst Rev, 2006(2): CD005328.
18. 　Kobayashi M, Squires GR, Mousa A, et al. Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage[J]. Arthritis Rheum, 2005, 52(1): 128-135.
19. 　Pelletier JP, Dibattista JA, Roughley P, et al. Cytokines and inflammation in cartilage degradation[J]. Rheum Dis Clin North Am, 1993, 19(3): 545-568.
20. 　Martel-Pelletier J, Mineau F, Jolicoeur FC, et al. In vitro effects of diacerhein and rhein on interleukin 1 and tumor necrosis factor-alpha systems in human osteoarthritic synovium and chondrocytes[J]. J Rheumatol, 1998, 25(4): 753-762.
21. 　Felisaz N, Boumediene K, Ghayor C, et al. Stimulating effect of diacerein on TGF-beta1 and beta2 expression in articular chondrocytes cultured with and without interleukin-1[J]. Osteoarthritis Cartilage, 1999, 7(3): 255-264.
22. 　Rintelen B, Neumann K, Leeb BF. A meta-analysis of controlled clinical studies with diacerein in the treatment of osteoarthritis[J]. Arch Intern Med, 2006, 166(17): 1899-1906.
23. 　Schnitzer TJ. New pharmacologic approaches in the management of osteoarthritis[J]. Arthritis Care Res (Hoboken), 2010, 62(8): 1174-1180.
24. 　Karsdal MA, Byrjalsen I, Henriksen K, et al. The effect of oral salmon calcitonin delivered with 5-CNAC on bone and cartilage degradation in osteoarthritic patients: a 14-day randomized study[J]. Osteoarthritis Cartilage, 2010, 18(2): 150-159.
25. 　Wan R, Hu J, Zhou Q, et al. Application of co-expressed genes to articular cartilage: new hope for the treatment of osteoarthritis (review)[J]. Mol Med Report, 2012, 6(1): 16-18.
26. 　Intema F, Van Roermund PM, Marijnissen AC, et al. Tissue structure modification in knee osteoarthritis by use of joint distraction: an open 1-year pilot study[J]. Ann Rheum Dis, 2011, 70(8): 1441-1446.
27. 　Zaffagnini S, Marcheggiani Muccioli GM, Lopomo N, et al. Prospective long-term outcomes of the medial collagen meniscus implant versus partial medial meniscectomy: a minimum 10-year follow-up study[J]. Am J Sports Med, 2011, 39(5): 977-985.
  1. 1. 　Felson DT, Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention[J]. Arthritis Rheum, 1998, 41(8): 1343-1355.
  2. 2. 　徐苓, Michael CN, Zhang YQ, et al. 北京城區(qū)老年人膝、髖和手骨關節(jié)炎的患病率及其與美國白人患病率的比較研究[J]. 中華醫(yī)學雜志, 2003, 83(14): 1206-1209.
  3. 3. 　Towheed TE, Maxwell L, Judd MG, et al. Acetaminophen for osteoarthritis[J]. Cochrane Database Syst Rev, 2006(1): CD004257.
  4. 4. 　Schnitzer TJ, American College of Rheumatology. Update of ACR guidelines for osteoarthritis: role of the coxibs[J]. J Pain Symptom Manage, 2002, 23(4 Suppl): S24-S30.
  5. 5. 　Hochberg MC, Altman RD, April KT, et al. American college of rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee[J]. Arthritis Care Res (Hoboken), 2012, 64(4): 465-474.
  6. 6. 　Langman MJ, Jensen DM, Watson DJ, et al. Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs[J]. JAMA, 1999, 282(20): 1929-1933.
  7. 7. 　Anon. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines[J]. Arthritis Rheum, 2000, 43(9): 1905-1915.
  8. 8. 　Anon. The management of chronic pain in older persons: AGS Panel on Chronic Pain in Older Persons. American Geriatrics Society[J]. J Am Geriatr Soc, 1998, 46(5): 635-651.
  9. 9. 　Biswal S, Medhi B, Pandhi P. Longterm efficacy of topical nonsteroidal antiinflammatory drugs in knee osteoarthritis: metaanalysis of randomized placebo controlled clinical trials[J]. J Rheumatol, 2006, 33(9): 1841-1844.
  10. 10. 　Lin J, Zhang W, Jones A, et al. Efficacy of topical non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomised controlled trials[J]. BMJ, 2004, 329(7461): 324.
  11. 11. 　Zhang WY, Li Wan Po A. The effectiveness of topically applied capsaicin. A meta-analysis[J]. Eur J Clin Pharmacol, 1994, 46(6): 517-522.
  12. 12. 　Pelletier JP, Martel-Pelletier J. Therapeutic targets in osteoarthritis: from today to tomorrow with new imaging technology[J]. Ann Rheum Dis, 2003, 62(Suppl 2): ii79-ii82.
  13. 13. 　Richy F, Bruyere O, Ethgen O, et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis[J]. Arch Intern Med, 2003, 163(13): 1514-1522.
  14. 14. 　Durmus D, Alayli G, Aliyazicioglu Y, et al. Effects of glucosamine sulfate and exercise therapy on serum leptin levels in patients with knee osteoarthritis: preliminary results of randomized controlled clinical trial[J/OL]. Rheumatol Int, 2012. [2012-11-01]. http://link.springer.com/content/pdf/10.1007%2Fs00296-012-2401-9.
  15. 15. 　Bruyere O, Pavelka K, Rovati LC, et al. Total joint replacement after glucosamine sulphate treatment in knee osteoarthritis: results of a mean 8-year observation of patients from two previous 3-year, randomised, placebo-controlled trials[J]. Osteoarthritis Cartilage, 2008, 16(2): 254-260.
  16. 16. 　Mcalindon TE, Lavalley MP, Gulin JP, et al. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis[J]. JAMA, 2000, 283(11): 1469-1475.
  17. 17. 　Bellamy N, Campbell J, Robinson V, et al. Intraarticular corticosteroid for treatment of osteoarthritis of the knee[J]. Cochrane Database Syst Rev, 2006(2): CD005328.
  18. 18. 　Kobayashi M, Squires GR, Mousa A, et al. Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage[J]. Arthritis Rheum, 2005, 52(1): 128-135.
  19. 19. 　Pelletier JP, Dibattista JA, Roughley P, et al. Cytokines and inflammation in cartilage degradation[J]. Rheum Dis Clin North Am, 1993, 19(3): 545-568.
  20. 20. 　Martel-Pelletier J, Mineau F, Jolicoeur FC, et al. In vitro effects of diacerhein and rhein on interleukin 1 and tumor necrosis factor-alpha systems in human osteoarthritic synovium and chondrocytes[J]. J Rheumatol, 1998, 25(4): 753-762.
  21. 21. 　Felisaz N, Boumediene K, Ghayor C, et al. Stimulating effect of diacerein on TGF-beta1 and beta2 expression in articular chondrocytes cultured with and without interleukin-1[J]. Osteoarthritis Cartilage, 1999, 7(3): 255-264.
  22. 22. 　Rintelen B, Neumann K, Leeb BF. A meta-analysis of controlled clinical studies with diacerein in the treatment of osteoarthritis[J]. Arch Intern Med, 2006, 166(17): 1899-1906.
  23. 23. 　Schnitzer TJ. New pharmacologic approaches in the management of osteoarthritis[J]. Arthritis Care Res (Hoboken), 2010, 62(8): 1174-1180.
  24. 24. 　Karsdal MA, Byrjalsen I, Henriksen K, et al. The effect of oral salmon calcitonin delivered with 5-CNAC on bone and cartilage degradation in osteoarthritic patients: a 14-day randomized study[J]. Osteoarthritis Cartilage, 2010, 18(2): 150-159.
  25. 25. 　Wan R, Hu J, Zhou Q, et al. Application of co-expressed genes to articular cartilage: new hope for the treatment of osteoarthritis (review)[J]. Mol Med Report, 2012, 6(1): 16-18.
  26. 26. 　Intema F, Van Roermund PM, Marijnissen AC, et al. Tissue structure modification in knee osteoarthritis by use of joint distraction: an open 1-year pilot study[J]. Ann Rheum Dis, 2011, 70(8): 1441-1446.
  27. 27. 　Zaffagnini S, Marcheggiani Muccioli GM, Lopomo N, et al. Prospective long-term outcomes of the medial collagen meniscus implant versus partial medial meniscectomy: a minimum 10-year follow-up study[J]. Am J Sports Med, 2011, 39(5): 977-985.