【摘要】 目的 評價大分割適形放射治療對腹膜后軟組織腫瘤術(shù)后患者的治療作用。 方法 對1998年10月-2003年4月收治的16例腹膜后軟組織急性腫瘤術(shù)后患者行大分割適形放射治療，設(shè)計臨床靶區(qū)等效生物劑量為55～62 Gy，觀察放療后2、5年局部控制率、生存率和無病生存情況。 結(jié)果 2、5年局部控制率較未行放療患者明顯提高并和其他放射治療方式達到較高治療劑量者近似；遠期生存無改善，無病生存率較未行放療患者有提高。 結(jié)論 大分割適形放射治療方式對腹膜后軟組織急性腫瘤術(shù)后患者有較好的局部控制作用，無瘤生存率有提高，遠期生存無改善，無嚴重的遠期放療后遺癥。
【Abstract】 Objective To observe the effect of high-dose three-dimensional conformal radiotherapy combined with surgery on primary retroperitoneal soft tissue sarcoma. Methods A total of 16 patients with primary retroperitoneal soft tissue sarcoma underwent high-dose three-dimensional conformal radiotherapy after sarcoma excision from October 1998 to April 2003. The biologically effective dose was 55-62 Gy for CTV. The local control rate and long-term survival rate and disease free survival after 2 and 5 years were observed. Results The local control rate obviously raised in these patients after 2 and 5 years; but the long-term survival rate didn’t improve and the disease free survival improved in these patients compared with those wasn’t radiated. Conclusion High-dose three-dinensional comfomal radiotherapy is effective on the patients with retroperitoneal soft tissue sarcoma in local control rate and disease free survival, but long-term survival rate is not improved and the side-effect is not serious.
引用本文： 劉煥義,駱建華,潘興國. 手術(shù)結(jié)合大分割適形放射治療腹膜后軟組織惡性腫瘤. 華西醫(yī)學(xué), 2010, 25(12): 2164-2166. doi: 復(fù)制
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- 2. Voros D, Theodorou D, Ventouri K, et al. Retroperitoneal tumors: do the satellite tumors mean something? [J]. J Surg Oncol, 1998, 68(1): 30-33.
- 3. Stoeckle E, Coindre M, Bonvalot S, et al. Prognostic factors in retroperitoneal sarcoma a multivariate analysis of a series of 165 patients of the French Cancer Center Federation Sarcoma Group[J]. Cancer, 2001, 92(2): 359-368.
- 4. 劉士新, 王佳銘, 何若吉, 等. 76例軟組織肉瘤術(shù)后放療的臨床觀察[J]. 實用腫瘤學(xué)雜志, 2001, 15(1): 40-41.
- 5. Mendenhall WM, Zlotechi RA, Hochwald SN, et al. Retroperitoneal soft tissue sarcoma[J]. Cancer, 2005, 104(4): 669-756.
- 6. 王淑蓮, 劉新帆, 李曄雄, 等. 75例腹膜后軟組織肉瘤的臨床分析[J] 中華放射腫瘤學(xué)雜志, 2004, 13(4): 298-301.
- 7. Singer S, Corson JM, Demetri GD, et al. Prognostic factors predictive of survival for truncal and retroperito-neal soft tissue sarcoma[J]. Ann Surg, 1995, 221(2): 185-195.