• 四川大學(xué)華西醫(yī)院放射科（成都，610041）;

【摘要】　目的　 利用首過時間技術(shù)進(jìn)行全胰腺CT灌注掃描，了解正常胰腺CT灌注的特點(diǎn)。　方法　 2006年6月-2007年3月， 64例正常胰腺患者行64排螺旋CT灌注掃描，測量胰頭、胰體及胰尾的灌注值、強(qiáng)化峰值、達(dá)峰時間和血容量。分別按患者的性別、年齡及胰腺測量的部位分組，將灌注參數(shù)進(jìn)行統(tǒng)計分析。　結(jié)果　 ①男性胰腺的血容量高于女性（P lt;0.05），其余灌注參數(shù)在兩性間差異無統(tǒng)計學(xué)意義（P gt;0.05）。②41~60歲組的灌注值低于 lt;40歲組和 gt;60歲組； gt;60歲組的強(qiáng)化峰值高于41~60歲組；41~60歲組的達(dá)峰時間長于 lt;40歲組； gt;60歲組的血容量高于41~60歲組（P lt;0.05）。③胰體和胰尾的灌注值高于胰頭（P lt;0.05），其余灌注參數(shù)在胰腺不同部位差異無統(tǒng)計學(xué)意義。　結(jié)論　 正常胰腺血流狀況在不同性別、不同年齡段及不同部位存在差異，首過時間技術(shù)應(yīng)用于正常胰腺能反映這些特征。
【Abstract】　Objective　 To investigate the CT perfusion features of normal pancreas with first-pass technique with 64-MDCT.　Methods　 Perfusion CT was performed on 64 patients with normal pancreas from June 2006 to March 2007. Four perfusion parameters, including perfusion, peak enhancement, time to peak, and blood volume, were obtained at the head, body and tail of the pancreas. Perfusion parameters were compared between different sexes, among different age groups and among different sites.　Results　 ① Blood volume of male was significantly higher than that of female (P lt;0.05). ② The perfusion value in the age group of 41-60 was significantly lower than that in the age group of  lt;40 and  gt;60 (P lt;0.05). The peak enhancement in the age group of  gt;60 was significantly higher than that in the age group of 41-60 (P lt;0.05). The time to peak in the age group of 41-60 was significantly longer than that in the age group of  lt;40 (P lt;0.05). The blood volume in the age group of  gt;60 was significantly higher than that in the age group of 41-60 (P lt;0.05). ③The perfusion values of the body and the tail were significantly higher than that of the head (P lt;0.05).　Conclusion　 There are significant differences in the perfusion parameters between different sexes and among several age groups and sites. The first-pass technique of perfusion applied in normal pancreas can reflect these features.

引用本文： 姚晉,楊志剛. 正常胰腺螺旋CT首過時間灌注特點(diǎn). 華西醫(yī)學(xué), 2010, 25(12): 2191-2194. doi: 復(fù)制

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2. 　Bertelli E, Di gregorio F, Bertelli L, et al. The arterial blood supply of the pancreas: a review I. The superior pancreati-coduodenal and the anterior superior pancreaticoduodenal arteries. An anatomical and radiological study [J]. Surg Radiol Anat, 1995, 17(2): 97-106.
3. 　Bertelli E, Di Gregorio F, Bertelli L, et al. The arterial blood supply of the pancreas: a review. Ⅱ. The posterior superior pancreaticoduodenal artery: an anatomical and radiological study[J]. Surg Radiol Anat, 1996, 18(1): 1-9.
4. 　Bertelli E, Di Gregorio F, Bertelli L, et al. The arterial blood supply of the pancreas: a review. Ⅲ. The inferior pancreaticoduodenal artery. An anatomical review and a radiological study [J]. Surg Radiol Anat, 1996, 18(2): 67-74.
5. 　Bertelli E, Di Gregorio F, Bertelli L, et al. The arterial blood supply of the pancreas: a review. Ⅳ. The anterior inferior and posterior pancreaticoduodenal aa, and minor sources of blood supply for the head of the pancreas. An anatomical review and radiologic study [J]. Surg Radiol Anat, 1997, 19(4): 203-212.
6. 　Bertelli E, Di Gregorio F, Bertelli L, et al. The arterial blood supply of the pancreas: a review. V. The dorsal pancreatic artery. An anatomic review and a radiologic study [J]. Surg Radiol Anat, 1998, 20(6): 445-452.
7. 　王芳軍, 陳衛(wèi)昌, 郭亮, 等. 正常胰腺64 層螺旋CT灌注成像的特征研究[J]. CT理論與應(yīng)用研究, 2009, 18(2): 83-91.
8. 　夏進(jìn)東, 周翔平. 正常胰腺組織的多層螺旋 CT血流灌注研究[J]. 臨床放射學(xué)雜志, 2009, 28(1): 58-62.
9. 　Tsushima Y, Kusano S. Age-dependent decline in parenchymal perfusion in the normal human pancreas: measurement by dynamic computedtomography [J]. Pancreas, 1998, 17 (2): 148-152.
10. 　趙心明, 周純武, 吳寧, 等. 胰腺多層螺旋CT灌注研究[J]. 中華放射學(xué)雜志, 2003, 37 (9): 845-849.
11. 　Kandel S, Kloeters C, Meyer H, et al. Whole-organ perfusion of the pancreas using dynamic volume CT in patients with primary pancreas carcinoma: acquisition technique, post-processing and initial results [J]. Eur Radiol, 2009, 19(11): 2641-2646.
12. 　Bali MA, Metens T, Denolin V, et al. Pancreatic perfusion: noninvasive quantitative assessment with dynamic contrast-enhanced MR imaging without and with secretin stimulation in healthy volunteers--initial results [J]. Radiology, 2008, 247(1): 115-121.
13. 　Xu J, Liang Z, Hao S, et al. Pancreatic adenocarcinoma: dynamic 64-slice helical CT with perfusion imaging [J]. Abdom Imaging, 2009, 34(6): 759-766.
14. 　林曉珠, 陳克敏. CT灌注成像測量正常胰腺組織血流灌注[J]. 中國CT 和MRI雜志, 2004, 2(1): 29-32.
  1. 1. 　Miles KA. Ideal contrast medium bolus for perfusion measurement in dynamic lung CT[J]. Radiology, 1998, 209(2): 584-585.
  2. 2. 　Bertelli E, Di gregorio F, Bertelli L, et al. The arterial blood supply of the pancreas: a review I. The superior pancreati-coduodenal and the anterior superior pancreaticoduodenal arteries. An anatomical and radiological study [J]. Surg Radiol Anat, 1995, 17(2): 97-106.
  3. 3. 　Bertelli E, Di Gregorio F, Bertelli L, et al. The arterial blood supply of the pancreas: a review. Ⅱ. The posterior superior pancreaticoduodenal artery: an anatomical and radiological study[J]. Surg Radiol Anat, 1996, 18(1): 1-9.
  4. 4. 　Bertelli E, Di Gregorio F, Bertelli L, et al. The arterial blood supply of the pancreas: a review. Ⅲ. The inferior pancreaticoduodenal artery. An anatomical review and a radiological study [J]. Surg Radiol Anat, 1996, 18(2): 67-74.
  5. 5. 　Bertelli E, Di Gregorio F, Bertelli L, et al. The arterial blood supply of the pancreas: a review. Ⅳ. The anterior inferior and posterior pancreaticoduodenal aa, and minor sources of blood supply for the head of the pancreas. An anatomical review and radiologic study [J]. Surg Radiol Anat, 1997, 19(4): 203-212.
  6. 6. 　Bertelli E, Di Gregorio F, Bertelli L, et al. The arterial blood supply of the pancreas: a review. V. The dorsal pancreatic artery. An anatomic review and a radiologic study [J]. Surg Radiol Anat, 1998, 20(6): 445-452.
  7. 7. 　王芳軍, 陳衛(wèi)昌, 郭亮, 等. 正常胰腺64 層螺旋CT灌注成像的特征研究[J]. CT理論與應(yīng)用研究, 2009, 18(2): 83-91.
  8. 8. 　夏進(jìn)東, 周翔平. 正常胰腺組織的多層螺旋 CT血流灌注研究[J]. 臨床放射學(xué)雜志, 2009, 28(1): 58-62.
  9. 9. 　Tsushima Y, Kusano S. Age-dependent decline in parenchymal perfusion in the normal human pancreas: measurement by dynamic computedtomography [J]. Pancreas, 1998, 17 (2): 148-152.
  10. 10. 　趙心明, 周純武, 吳寧, 等. 胰腺多層螺旋CT灌注研究[J]. 中華放射學(xué)雜志, 2003, 37 (9): 845-849.
  11. 11. 　Kandel S, Kloeters C, Meyer H, et al. Whole-organ perfusion of the pancreas using dynamic volume CT in patients with primary pancreas carcinoma: acquisition technique, post-processing and initial results [J]. Eur Radiol, 2009, 19(11): 2641-2646.
  12. 12. 　Bali MA, Metens T, Denolin V, et al. Pancreatic perfusion: noninvasive quantitative assessment with dynamic contrast-enhanced MR imaging without and with secretin stimulation in healthy volunteers--initial results [J]. Radiology, 2008, 247(1): 115-121.
  13. 13. 　Xu J, Liang Z, Hao S, et al. Pancreatic adenocarcinoma: dynamic 64-slice helical CT with perfusion imaging [J]. Abdom Imaging, 2009, 34(6): 759-766.
  14. 14. 　林曉珠, 陳克敏. CT灌注成像測量正常胰腺組織血流灌注[J]. 中國CT 和MRI雜志, 2004, 2(1): 29-32.