• 1四川大學(xué)華西醫(yī)院內(nèi)分泌科，四川成都 610041;2王曉茜現(xiàn)工作單位：四川省德陽(yáng)市人民醫(yī)院;

目的：對(duì)原發(fā)性脂肪肝（PFLD）患者及健康對(duì)照的一級(jí)親屬中PFLD發(fā)生情況、胰島素抵抗（HOMA-IR）指數(shù)以及其他相關(guān)代謝指標(biāo)的測(cè)定，了解PFLD是否有家族集聚現(xiàn)象及IR在其發(fā)病中的可能作用。方法：PFLD的診斷依據(jù)B超為脂肪肝并排除繼發(fā)性原因。PFLD家系組（A組）共42例，11個(gè)家庭。選取與A組年齡、性別構(gòu)成及生活方式和經(jīng)濟(jì)狀況相近的健康志愿者家系為對(duì)照組（B組）共14例，4個(gè)家庭。所有受試者均進(jìn)行身高、體重、腰圍、血壓等測(cè)定，行糖耐量試驗(yàn)、胰島素及血脂質(zhì)等檢測(cè)，并對(duì)受試者的生活方式及文化程度和經(jīng)濟(jì)狀況行量化打分。結(jié)果：A組PFLD 33例（78.57%，A1組），無(wú)脂肪肝9例（A2組），說(shuō)明有家族集聚現(xiàn)象。與B組相比，A1組的體重指數(shù)、腰圍、舒張壓、血總膽固醇和HOMA-IR指數(shù)顯著高于B組（P＜0.05）；血高密度脂蛋白膽固醇（HDL-C）顯著低于B（P＜0.05）；A2組的各項(xiàng)指標(biāo)與B組相比差異無(wú)統(tǒng)計(jì)學(xué)意義，但變化趨勢(shì)呈現(xiàn)出腹型肥胖、IR、代謝紊亂和血壓偏高；而A1組及A2組與B組的生活方式及經(jīng)濟(jì)狀況無(wú)明顯差異。結(jié)論：PFLD具有較強(qiáng)的家族聚發(fā)現(xiàn)象，其IR程度顯著高于對(duì)照組；家族中無(wú)脂肪肝者存在IR相關(guān)的代謝紊亂趨勢(shì)。說(shuō)明某種內(nèi)在或遺傳因素如IR可能與PFLD發(fā)病有關(guān)。

引用本文： 王曉茜,童南偉. 胰島素抵抗與原發(fā)性脂肪肝家族集聚現(xiàn)象的初步研究. 華西醫(yī)學(xué), 2008, 23(1): 45-47. doi: 復(fù)制

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