目的：對TGF-β1的G-800A，C-509T，T869C和G915C多態(tài)性位點(diǎn)與IgA腎病及其臨床表現(xiàn)之間的相關(guān)性進(jìn)行了分析。方法：納入119例經(jīng)腎活檢證實(shí)為IgA腎病的患者和116例健康正常成人作為對照組。采用多聚酶鏈?zhǔn)椒磻?yīng)-限制片段長度多態(tài)性分析和多聚酶鏈?zhǔn)椒磻?yīng)-擴(kuò)增受阻突變體系方法測定TGF-β1的G-800A，C-509T，T869C和G915C多態(tài)性位點(diǎn)的基因型，分析其與IgA腎病發(fā)病以及臨床表現(xiàn)的相關(guān)性。結(jié)果：研究對象中G-800A和G+915C這兩個(gè)位點(diǎn)沒有多態(tài)性。IgAN患者C-509T位點(diǎn)的等位基因型分布與正常對照具有顯著性差異（Ｐ＜0.05），且IgAN患者TT純合子的頻率顯著高于對照組（33% vs 20%,Ｐ=0.02）。C869T位點(diǎn)等位基因的分布無顯著性差異。C-509T和C869T位點(diǎn)等位基因分布和患者臨床表現(xiàn)無明顯的相關(guān)性。結(jié)論：TGF-β1基因C-509T位點(diǎn)的T等位基因攜帶可能與IgA腎病的發(fā)病易感性具有相關(guān)性。
引用本文： 秦偉,張穎娟,譚淳予,劉先蓉,馬行一,樊均明. IgA腎病和TGF-β1基因多態(tài)性的相關(guān)性研究. 華西醫(yī)學(xué), 2008, 23(1): 61-63. doi: 復(fù)制
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- 1. Barratt,J.and J.Feehally.IgA nephropathy[J].J Am Soc Nephrol,2005,16(7):2088-97.
- 2. 秦偉,李學(xué)旺,秦巖,等.傳遞不平衡檢測IL-1β基因多態(tài)性和IgA腎病的相關(guān)性[J].華西醫(yī)學(xué),2007,22(2):305-307.
- 3. Fan J,M,Y Y Ng,P A Hill,et al.Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro[J].Kidney Int,1999,56(4):1455-67.
- 4. 沈蓮莉,鄧躍毅.轉(zhuǎn)化生長因子-β1與IgA腎病[J].中國中西醫(yī)結(jié)合腎病雜志,2006,7(3):180-181.
- 5. K/DOQI clinical practice guidelines for chronic kidney disease:evaluation,classification,and stratification[J].Am J Kidney Dis,2002,39(2 Suppl 1):S1-266.
- 6. Perrey C,S J Turner,V Pravica,et al.ARMS-PCR methodologies to determine IL-10,TNF-alpha,TNF-beta and TGF-beta 1 gene polymorphisms [J].Transpl Immunol,1999,7(2):p.127-8.
- 7. 王文新,張青霞,劉宏偉,等.TGF-β1在IgA腎病患者腎組織中的表達(dá)[J].基礎(chǔ)醫(yī)學(xué)與臨床,2002,22(1):43-44.
- 8. Grainger D J,K Heathcote,M Chiano,et al.Genetic control of the circulating concentration of transforming growth factor type beta1[J].Hum Mol Genet,1999,8(1)93-7.
- 9. Yokota M,S.Ichihara,T L Lin,et al.Association of a T29--＞C polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to myocardial infarction in Japanese[J].Circulation,2000,101(24):2783-7.
- 10. Lim C S,Y S Kim,D W Chae,et al.Association of C-509T and T869C polymorphisms of transforming growth factor-beta1 gene with susceptibility to and progression of IgA nephropathy[J].Clin Nephrol,2005,63(2):61-7.
- 11. 薛超,李幼姬,李彩霞,等.基于家庭的TGF-β1-509C/T多態(tài)性和IgA腎病相關(guān)性研究 [J].中國病理生理雜志,2005,21(3):422-426.
- 12. Sato F,I Narita,S Goto,et al.Transforming growth factor-beta1 gene polymorphism modifies the histological and clinical manifestations in Japanese patients with IgA nephropathy[J].Tissue Antigens,2004,64(1):35-42.