• 1四川省成都市第二人民醫(yī)院心內科，四川成都 610017;2第三軍醫(yī)大學西南醫(yī)院老年科，重慶 400038;

目的：采用常壓間歇性低氧(intermittent hypoxia,IH)大鼠的動物模型，觀察間歇性常壓低氧預處理的促血管生成作用。方法:成年雄性Wistar大鼠25只，體重210～215 g，隨機分為2大組:對照組(C組，n=5)和間歇性低氧預處理組(IH組，n=20)。IH組動物進行間歇性低氧預處理(4 h/d，間歇缺氧1 d者為IH1組，7 d者為IH2組，14 d者為IH3組，28 d者為IH4組)，按計劃完成實驗后測定心肌血管內皮生長因子(VEGF) 蛋白表達及毛細血管密度。結果：間歇性低氧預處理大鼠心肌VEGF蛋白表達增加，心肌毛細血管密度增高。結論：間歇性低氧預處理能促進大鼠心肌內的血管生成，其機制可能與心肌VEGF表達增高有關。

引用本文： 張文勇,王璋,李秋,趙思勤,聶曉莉,胡詠梅. 間歇性低氧預處理對大鼠心肌促血管生成作用的實驗研究. 華西醫(yī)學, 2008, 23(1): 108-109. doi: 復制

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