丁宇 1 , 范紅 1,2
  • 四川大學(xué)華西醫(yī)院（成都，610041）1 呼吸內(nèi)科，2 實(shí)驗(yàn)醫(yī)學(xué)科;

引用本文： 丁宇,范紅. 天然植物活性成份白藜蘆醇的抗炎作用研究進(jìn)展. 華西醫(yī)學(xué), 2008, 23(1): 199-200. doi: 復(fù)制

1. 　Aggarwal BB, Bhardwaj A, Aggarwal RS, et al. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies[J]. Anticancer Res, 2004, 24: 3-60.
2. 　Blackwell TS, Christman JW. The role of nuclear factor-κB in cytokine gene regulation[J]. Am J Respir Cell Mol Biol, 1997, 17: 3-9.
3. 　Zingarelli B, Sheehan M, Wong HR. Nuclear factor-κB as a therapeutic target in critical care medicine[J]. Crit Care Med, 2003, 31(1 Suppl): S105-S111.
4. 　Dichtl W, Dulak J, Frick M, et al. HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells[J]. Arterioscler Thromb Vasc Biol, 2003, 23(1): 58-63.
5. 　Leiro J, Arranz JA, Fraiz N, et al. Effect of cis-resveratrol on genes involved in nuclear factor kappa B signaling[J]. Int Immunopharmacol, 2005, 5(2): 393-406.
6. 　Donnelly LE, Newton R, Kennedy GE, et al. Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms[J]. Am J Physiol Lung Cell Mol Physiol, 2004, 287: L774-L783.
7. 　Cullen JP, Morrow D, Jin Y, et al. Resveratrol, a polyphenolic phytostilbene, inhibits endothelial monocyte chemotactic protein-1 synthesisand secretion[J]. J Vasc Res, 2007, 44(1): 75-84.
8. 　Manna SK, Mukhopadhyay A, Aggarwal BB. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-κB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation[J]. J Immunol, 2000, 164(12): 6509-6519.
9. 　Shen F, Chen SJ, Dong XJ, et al. Suppression of IL-8 genetranscription by resveratrol in phorbol ester treated human monocytic cells[J]. J Asian Nat Prod Res, 2003, 5(2): 151-157.
10. 　Crofford LJ. COX-1 and COX-2 tissue expression: implications and predictions[J]. J Rheumatol Suppl, 1997, 49: 15-19.
11. 　Appleby SB, Ristimaki A, Neilson K, et al. Structure of the human cyclo-oxygenase-2 gene[J]. Biochem J, 1994, 302(pt): 723-727.
12. 　Futani H, Okayama A, Matsui K, et al. Relation between interleukin -18 and PGE2 in synovial fluid of osteoarthritis: a potential therapeutic target of cartilage degradation[J]　 . J Immunol, 2002, 25(Suppl 1): 61-64.
13. 　Crofford LJ, Wilder RL, Ristimaki AP, et al. Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1beta, phorbol ester, and corticosteroids[J]. J ClinInvest, 1994, 93(3): 1095-1101.
14. 　Gilroy DW, Colville-Nash PR, Willis D, et al. Inducible cyclooxygenase may have anti-inflammatory properties[J]. Nat Med, 1999, 5(6) : 698-701.
15. 　Jang M, Cai L, Udeani GO, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes[J]. Sci, 1997, 275: 218-20.
16. 　Martinez J, Moreno JJ. Effect of resveratrol, a naturalpolyphenolic compound, on reactive oxygen species and prostaglandin production[J]. Biochem Pharmacol, 2000, 59(7): 865-870.
17. 　Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease[J]. Clin Chim Acta, 1995, 235(2): 207-219.
18. 　Kundu JK, Shin YK, Kim SH, et al. Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-κB in mouse skin by blocking IκB kinase activity[J]. Carcinogenesis, 2006, 27(7): 1465-1474.
19. 　Kristof AS, Goldberg P, Laubach V, et al. Role of inducible nitric oxide synthase in endotoxin-induced acute lung injury[J]. Am J Respir Crit Care Med, 1998, 158 (6) : 1883-1889.
20. 　Tsai SH, Lin-Shiau SY, Lin JK. Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol[J]. Br J Pharmacol, 1999, 126(3): 673-680.
21. 　王錚, 馬清涌, 任雷，等. 白藜蘆醇對重癥急性胰腺炎急性肺損傷作用的實(shí)驗(yàn)研究[J]. 四川大學(xué)學(xué)報(bào)(醫(yī)學(xué)版), 2006, 37(6): 904-907.
22. 　Pendurthi UR, Williams JT, Rao LV. Acidic and basic fibroblast growth factors Suppress transcriptional activation of tissue factor and other inflammatory genes in endothelial cells[J]. Arterioscler Thromb Vasc Biol, 1997, 17(5): 940-946.
23. 　Szotowski B, Antoniak S, Poller W, et al. Procoagulant soluble tissue factor is released from endothelial cells in response to inflammatory cytokines[J]. Circ Res, 2005, 96(12): 1233-1239.
24. 　Pendurthi UR, Williams JT, Rao LV. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells: A possible mechanism for the cardiovascular benefitsassociated with moderate consumption of wine[J]. Arterioscler Thromb Vasc Biol, 1999, 19(2): 419-426.
25. 　Wang ZR, Huang YZ, Zou J, et al. Effects of red wine andwine polyphenol resveratrol on platelet aggregation in vivo and in vitro[J]. Int J Mol Med, 2002，9(1): 77-79.
26. 　Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol[J]. Drugs Exp Clin Res, 1996, 22(2): 61-63.
27. 　Kaneider NC, Mosheimer B, Reinisch N, et al. Inhibition of thrombin-induced signaling by resveratrol and quercetin: effects on adenosine nucleotide metabolism in endothelial cells and platelet-neutrophil interactions[J]. Thromb Res, 2004, 114(3): 185-194.
28. 　Ahn KS, Kim JH, Oh SR, et al. Inhibitory activity of stilbenes from medicinal plants on the expression of cell adhesion molecules on THP1 cells[J]. Planta Med, 2000, 66(7): 641-644.
29. 　Meng Y, Zhang M, Xu J, et al. Effect of resveratrol on microcirculation disorder and lung injury following severe acute pancreatitis in rats[J]. World J Gastroenterol, 2005, 11(3): 433-435.
30. 　Wung BS, Hsu MC, Wu CC, et al. Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: effects on the inhibitionof STAT3 phosphorylation[J]. Life Sci, 2005, 78(4): 389-397.
31. 　Mahady GB, Pendland SL, Chadwick LR. Resveratrol and red wine extracts inhibit the growth of CagA+ strains of Helicobacter pylori in vitro[J]. Am J Gastroenterol, 2003, 98(6): 1440-1441.
32. 　Wang WB, Lai HC, Hsueh PR, et al. Inhibition of swarmingand virulence factor expression in Proteus mirabilis by resveratrol[J]. J Med Microbiol, 2006, 55(10): 1313-1321.
33. 　Faith SA, Sweet TJ, Bailey E, et al. Resveratrol suppresses nuclear factor-kappaB in herpes simplex virus infected cells[J]. Antiviral Res, 2006, 72(3): 242-251.
34. 　Feng YH, Zhou WL, Wu QL, et al. Low dose of resveratrolenhanced immune response of mice[J]. Acta Pharmacol Sin, 2002, 23(10): 893-897.
35. 　Tao HY, Wu CF, Zhou Y, et al. The grape component resveratrol interferes with the function of chemoattractant receptors on phagocytic leukocytes[J]. Cell Mol Immunol, 2004, 1(1): 50-56.
  1. 1. 　Aggarwal BB, Bhardwaj A, Aggarwal RS, et al. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies[J]. Anticancer Res, 2004, 24: 3-60.
  2. 2. 　Blackwell TS, Christman JW. The role of nuclear factor-κB in cytokine gene regulation[J]. Am J Respir Cell Mol Biol, 1997, 17: 3-9.
  3. 3. 　Zingarelli B, Sheehan M, Wong HR. Nuclear factor-κB as a therapeutic target in critical care medicine[J]. Crit Care Med, 2003, 31(1 Suppl): S105-S111.
  4. 4. 　Dichtl W, Dulak J, Frick M, et al. HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells[J]. Arterioscler Thromb Vasc Biol, 2003, 23(1): 58-63.
  5. 5. 　Leiro J, Arranz JA, Fraiz N, et al. Effect of cis-resveratrol on genes involved in nuclear factor kappa B signaling[J]. Int Immunopharmacol, 2005, 5(2): 393-406.
  6. 6. 　Donnelly LE, Newton R, Kennedy GE, et al. Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms[J]. Am J Physiol Lung Cell Mol Physiol, 2004, 287: L774-L783.
  7. 7. 　Cullen JP, Morrow D, Jin Y, et al. Resveratrol, a polyphenolic phytostilbene, inhibits endothelial monocyte chemotactic protein-1 synthesisand secretion[J]. J Vasc Res, 2007, 44(1): 75-84.
  8. 8. 　Manna SK, Mukhopadhyay A, Aggarwal BB. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-κB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation[J]. J Immunol, 2000, 164(12): 6509-6519.
  9. 9. 　Shen F, Chen SJ, Dong XJ, et al. Suppression of IL-8 genetranscription by resveratrol in phorbol ester treated human monocytic cells[J]. J Asian Nat Prod Res, 2003, 5(2): 151-157.
  10. 10. 　Crofford LJ. COX-1 and COX-2 tissue expression: implications and predictions[J]. J Rheumatol Suppl, 1997, 49: 15-19.
  11. 11. 　Appleby SB, Ristimaki A, Neilson K, et al. Structure of the human cyclo-oxygenase-2 gene[J]. Biochem J, 1994, 302(pt): 723-727.
  12. 12. 　Futani H, Okayama A, Matsui K, et al. Relation between interleukin -18 and PGE2 in synovial fluid of osteoarthritis: a potential therapeutic target of cartilage degradation[J]　 . J Immunol, 2002, 25(Suppl 1): 61-64.
  13. 13. 　Crofford LJ, Wilder RL, Ristimaki AP, et al. Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1beta, phorbol ester, and corticosteroids[J]. J ClinInvest, 1994, 93(3): 1095-1101.
  14. 14. 　Gilroy DW, Colville-Nash PR, Willis D, et al. Inducible cyclooxygenase may have anti-inflammatory properties[J]. Nat Med, 1999, 5(6) : 698-701.
  15. 15. 　Jang M, Cai L, Udeani GO, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes[J]. Sci, 1997, 275: 218-20.
  16. 16. 　Martinez J, Moreno JJ. Effect of resveratrol, a naturalpolyphenolic compound, on reactive oxygen species and prostaglandin production[J]. Biochem Pharmacol, 2000, 59(7): 865-870.
  17. 17. 　Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease[J]. Clin Chim Acta, 1995, 235(2): 207-219.
  18. 18. 　Kundu JK, Shin YK, Kim SH, et al. Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-κB in mouse skin by blocking IκB kinase activity[J]. Carcinogenesis, 2006, 27(7): 1465-1474.
  19. 19. 　Kristof AS, Goldberg P, Laubach V, et al. Role of inducible nitric oxide synthase in endotoxin-induced acute lung injury[J]. Am J Respir Crit Care Med, 1998, 158 (6) : 1883-1889.
  20. 20. 　Tsai SH, Lin-Shiau SY, Lin JK. Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol[J]. Br J Pharmacol, 1999, 126(3): 673-680.
  21. 21. 　王錚, 馬清涌, 任雷，等. 白藜蘆醇對重癥急性胰腺炎急性肺損傷作用的實(shí)驗(yàn)研究[J]. 四川大學(xué)學(xué)報(bào)(醫(yī)學(xué)版), 2006, 37(6): 904-907.
  22. 22. 　Pendurthi UR, Williams JT, Rao LV. Acidic and basic fibroblast growth factors Suppress transcriptional activation of tissue factor and other inflammatory genes in endothelial cells[J]. Arterioscler Thromb Vasc Biol, 1997, 17(5): 940-946.
  23. 23. 　Szotowski B, Antoniak S, Poller W, et al. Procoagulant soluble tissue factor is released from endothelial cells in response to inflammatory cytokines[J]. Circ Res, 2005, 96(12): 1233-1239.
  24. 24. 　Pendurthi UR, Williams JT, Rao LV. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells: A possible mechanism for the cardiovascular benefitsassociated with moderate consumption of wine[J]. Arterioscler Thromb Vasc Biol, 1999, 19(2): 419-426.
  25. 25. 　Wang ZR, Huang YZ, Zou J, et al. Effects of red wine andwine polyphenol resveratrol on platelet aggregation in vivo and in vitro[J]. Int J Mol Med, 2002，9(1): 77-79.
  26. 26. 　Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol[J]. Drugs Exp Clin Res, 1996, 22(2): 61-63.
  27. 27. 　Kaneider NC, Mosheimer B, Reinisch N, et al. Inhibition of thrombin-induced signaling by resveratrol and quercetin: effects on adenosine nucleotide metabolism in endothelial cells and platelet-neutrophil interactions[J]. Thromb Res, 2004, 114(3): 185-194.
  28. 28. 　Ahn KS, Kim JH, Oh SR, et al. Inhibitory activity of stilbenes from medicinal plants on the expression of cell adhesion molecules on THP1 cells[J]. Planta Med, 2000, 66(7): 641-644.
  29. 29. 　Meng Y, Zhang M, Xu J, et al. Effect of resveratrol on microcirculation disorder and lung injury following severe acute pancreatitis in rats[J]. World J Gastroenterol, 2005, 11(3): 433-435.
  30. 30. 　Wung BS, Hsu MC, Wu CC, et al. Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: effects on the inhibitionof STAT3 phosphorylation[J]. Life Sci, 2005, 78(4): 389-397.
  31. 31. 　Mahady GB, Pendland SL, Chadwick LR. Resveratrol and red wine extracts inhibit the growth of CagA+ strains of Helicobacter pylori in vitro[J]. Am J Gastroenterol, 2003, 98(6): 1440-1441.
  32. 32. 　Wang WB, Lai HC, Hsueh PR, et al. Inhibition of swarmingand virulence factor expression in Proteus mirabilis by resveratrol[J]. J Med Microbiol, 2006, 55(10): 1313-1321.
  33. 33. 　Faith SA, Sweet TJ, Bailey E, et al. Resveratrol suppresses nuclear factor-kappaB in herpes simplex virus infected cells[J]. Antiviral Res, 2006, 72(3): 242-251.
  34. 34. 　Feng YH, Zhou WL, Wu QL, et al. Low dose of resveratrolenhanced immune response of mice[J]. Acta Pharmacol Sin, 2002, 23(10): 893-897.
  35. 35. 　Tao HY, Wu CF, Zhou Y, et al. The grape component resveratrol interferes with the function of chemoattractant receptors on phagocytic leukocytes[J]. Cell Mol Immunol, 2004, 1(1): 50-56.