• 四川省瀘州醫(yī)學院附屬醫(yī)院血管外科（瀘州646000）;

目的　 探討肺炎衣原體與腹主動脈瘤關(guān)系的最新進展。方法　采用文獻回顧的方法。對目前國內(nèi)、外有關(guān)肺炎衣原體和腹主動脈瘤的研究狀況進行分析與綜述。 結(jié)果　肺炎衣原體是腹主動脈瘤形成的重要因素，肺炎衣原體可能通過細胞外基質(zhì)代謝、血管平滑肌細胞凋亡、腹主動脈瘤壁的慢性感染等導(dǎo)致腹主動脈瘤的發(fā)生。結(jié)論　肺炎衣原體與腹主動脈瘤有著非常密切的關(guān)系，肺炎衣原體能引起腹主動脈瘤發(fā)生并在其發(fā)生、發(fā)展過程中占據(jù)重要的地位。

引用本文： 施森,何延政,劉勇,宋麗. 肺炎衣原體與腹主動脈瘤的關(guān)系. 中國普外基礎(chǔ)與臨床雜志, 2006, 13(6): 668-670. doi: 復(fù)制

1. 　Grayston JT, Campbell LA, Kuo CC, et al. A new respiratory tract pathogen: Chlamydia pneumoniae strain TWAR [J]. J Infect Dis, 1990; 161(4)∶618.
2. 　Robman L, Mahdi O, McCarty C, et al. Exposure to Chla-mydia pneumoniae infection and progression of age-related macular degeneration [J]. Am J Epidemiol, 2005; 161(11)∶1013.
3. 　Koyi H, Branden E, Gnarpe J, et al. An association between chronic infection with Chlamydia pneumoniae and lung cancer. A prospective 2-year study [J]. APMIS, 2001; 109(9)∶572.
4. 　Stuart ES, Webley WC, Norkin LC. Lipid rafts, caveolae, ca-veolin-1, and entry by Chlamydiae into host cells [J]. Exp Cell Res, 2003; 287(1)∶67.
5. 　Lindholt JS, Ashton HA, Scott RA. Indicators of infection with Chlamydia pneumoniae are associated with expansion of abdominal aortic aneurysms [J]. J Vasc Surg, 2001; 34(2)∶212.
6. 　Wolski A, Korobowicz E, Siezieniewska Z, et al. Immunofluorescence in situ and the serologic indices of Chlamydia pneumoniae infection in patients with an abdominal aortic aneurysm [J]. Pol J Pathol, 2002; 53(4)∶223.
7. 　Wolski A, Mazur E, Niedzwiadek J, et al. The relation between Chlamydia pneumoniae infection and abdominal aortic aneurysm [J]. Pol Merkuriusz Lek, 2001; 11(66)∶491.
8. 　Lindholt JS, Jorgensen B, Shi GP, et al. Relationships between activators and inhibitors of plasminogen, and the progression of small abdominal aortic aneurysms [J]. Eur J Vasc Endovasc Surg, 2003; 25(6)∶546.
9. 　 Mosorin M, Juvonen J, Biancari F, et al. Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: a randomized, double-blind, placebo-controlled pilot study [J]. J Vasc Surg, 2001; 34(4)∶606.
10. 　Tambiah J, Powell JT. Chlamydia pneumoniae antigens facilitate experimental aortic dilatation: prevention with azithromycin [J]. J Vasc Surg, 2002; 36(5)∶1011.
11. 　Wassef M, Baxter BT, Chisholm RL, et al. Pathogenesis of abdominal aortic aneurysms: a multidisciplinary research program supported by the National Heart, Lung, and Blood Institute [J]. J Vasc Surg, 2001; 34(4)∶730.
12. 　Tung WS, Lee JK, Thompson RW. Simultaneous analysis of 1176 gene products in normal human aorta and abdominal aortic aneurysms using a membrane-based complementary DNA expression array [J]. J Vasc Surg, 2001; 34(1)∶143.
13. 　Rodel J, Prochnau D, Prager K, et al. Increased production of matrix metalloproteinases 1 and 3 by smooth muscle cells upon infection with Chlamydia pneumoniae [J]. FEMS Immunol Med Microbiol, 2003; 38(2)∶159.
14. 　Airenne S, Surcel HM, Tuukkanen J, et al. Chlamydia pneumoniae inhibits apoptosis in human epithelial and monocyte cell lines [J]. Scand J Immunol, 2002; 55(4)∶390.
15. 　Ezzahiri R, Stassen FR, Kurvers HA, et al. Chlamydia pneumoniae infection induces an unstable atherosclerotic plaque phenotype in LDL-receptor, ApoE double knockout mice [J]. Eur J Vasc Endovasc Surg, 2003; 26(1)∶88.
16. 　袁中華， 楊永宗， 楊小毅， 等. 氧化型低密度脂蛋白誘導(dǎo)豬主動脈平滑肌細胞凋亡 [J]. 中國動脈硬化雜志， 2002； 10(1)∶23.
17. 　李　濤， 許香廣， 張國良， 等. 健康人群肺炎衣原體感染狀況分析 [J]. 中國醫(yī)學檢驗雜志， 2003； 2（4）∶66.
18. 　Gaydos CA, Summersgill JT, Sahney NN, et al. Replication of Chlamydia pneumoniae in vitro in human macrophages, endothelial cells, and aortic artery smooth muscle cells [J]. Infect Immun, 1996; 64(5)∶1614.
19. 　Kowalewski R, Sobolewski K, Malkowski A, et al. Evaluation of enzymes involved in proteoglycan degradation in the wall of abdominal aortic aneurysms [J]. J Vasc Res, 2006; 43(1)∶95.
20. 　Luan Z, Chase AJ, Newby AC. Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages [J]. Arterioscler Thromb Vasc Biol, 2003; 23(5)∶769.
21. 　Kim MP, Gaydos CA, Wood BJ, et al. Chlamydia pneumoniae enhances cytokine-stimulated human monocyte matrix metalloproteinases through a prostaglandin E2-dependent mechanism [J]. Infect Immun, 2005; 73(1)∶632.
22. 　Porqueddu M, Spirito R, Parolari A, et al. Lack of association between serum immunoreactivity and Chlamydia pneumoniae detection in the human aortic wall [J]. Circulation, 2002; 106(21)∶2647.
  1. 1. 　Grayston JT, Campbell LA, Kuo CC, et al. A new respiratory tract pathogen: Chlamydia pneumoniae strain TWAR [J]. J Infect Dis, 1990; 161(4)∶618.
  2. 2. 　Robman L, Mahdi O, McCarty C, et al. Exposure to Chla-mydia pneumoniae infection and progression of age-related macular degeneration [J]. Am J Epidemiol, 2005; 161(11)∶1013.
  3. 3. 　Koyi H, Branden E, Gnarpe J, et al. An association between chronic infection with Chlamydia pneumoniae and lung cancer. A prospective 2-year study [J]. APMIS, 2001; 109(9)∶572.
  4. 4. 　Stuart ES, Webley WC, Norkin LC. Lipid rafts, caveolae, ca-veolin-1, and entry by Chlamydiae into host cells [J]. Exp Cell Res, 2003; 287(1)∶67.
  5. 5. 　Lindholt JS, Ashton HA, Scott RA. Indicators of infection with Chlamydia pneumoniae are associated with expansion of abdominal aortic aneurysms [J]. J Vasc Surg, 2001; 34(2)∶212.
  6. 6. 　Wolski A, Korobowicz E, Siezieniewska Z, et al. Immunofluorescence in situ and the serologic indices of Chlamydia pneumoniae infection in patients with an abdominal aortic aneurysm [J]. Pol J Pathol, 2002; 53(4)∶223.
  7. 7. 　Wolski A, Mazur E, Niedzwiadek J, et al. The relation between Chlamydia pneumoniae infection and abdominal aortic aneurysm [J]. Pol Merkuriusz Lek, 2001; 11(66)∶491.
  8. 8. 　Lindholt JS, Jorgensen B, Shi GP, et al. Relationships between activators and inhibitors of plasminogen, and the progression of small abdominal aortic aneurysms [J]. Eur J Vasc Endovasc Surg, 2003; 25(6)∶546.
  9. 9. 　 Mosorin M, Juvonen J, Biancari F, et al. Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: a randomized, double-blind, placebo-controlled pilot study [J]. J Vasc Surg, 2001; 34(4)∶606.
  10. 10. 　Tambiah J, Powell JT. Chlamydia pneumoniae antigens facilitate experimental aortic dilatation: prevention with azithromycin [J]. J Vasc Surg, 2002; 36(5)∶1011.
  11. 11. 　Wassef M, Baxter BT, Chisholm RL, et al. Pathogenesis of abdominal aortic aneurysms: a multidisciplinary research program supported by the National Heart, Lung, and Blood Institute [J]. J Vasc Surg, 2001; 34(4)∶730.
  12. 12. 　Tung WS, Lee JK, Thompson RW. Simultaneous analysis of 1176 gene products in normal human aorta and abdominal aortic aneurysms using a membrane-based complementary DNA expression array [J]. J Vasc Surg, 2001; 34(1)∶143.
  13. 13. 　Rodel J, Prochnau D, Prager K, et al. Increased production of matrix metalloproteinases 1 and 3 by smooth muscle cells upon infection with Chlamydia pneumoniae [J]. FEMS Immunol Med Microbiol, 2003; 38(2)∶159.
  14. 14. 　Airenne S, Surcel HM, Tuukkanen J, et al. Chlamydia pneumoniae inhibits apoptosis in human epithelial and monocyte cell lines [J]. Scand J Immunol, 2002; 55(4)∶390.
  15. 15. 　Ezzahiri R, Stassen FR, Kurvers HA, et al. Chlamydia pneumoniae infection induces an unstable atherosclerotic plaque phenotype in LDL-receptor, ApoE double knockout mice [J]. Eur J Vasc Endovasc Surg, 2003; 26(1)∶88.
  16. 16. 　袁中華， 楊永宗， 楊小毅， 等. 氧化型低密度脂蛋白誘導(dǎo)豬主動脈平滑肌細胞凋亡 [J]. 中國動脈硬化雜志， 2002； 10(1)∶23.
  17. 17. 　李　濤， 許香廣， 張國良， 等. 健康人群肺炎衣原體感染狀況分析 [J]. 中國醫(yī)學檢驗雜志， 2003； 2（4）∶66.
  18. 18. 　Gaydos CA, Summersgill JT, Sahney NN, et al. Replication of Chlamydia pneumoniae in vitro in human macrophages, endothelial cells, and aortic artery smooth muscle cells [J]. Infect Immun, 1996; 64(5)∶1614.
  19. 19. 　Kowalewski R, Sobolewski K, Malkowski A, et al. Evaluation of enzymes involved in proteoglycan degradation in the wall of abdominal aortic aneurysms [J]. J Vasc Res, 2006; 43(1)∶95.
  20. 20. 　Luan Z, Chase AJ, Newby AC. Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages [J]. Arterioscler Thromb Vasc Biol, 2003; 23(5)∶769.
  21. 21. 　Kim MP, Gaydos CA, Wood BJ, et al. Chlamydia pneumoniae enhances cytokine-stimulated human monocyte matrix metalloproteinases through a prostaglandin E2-dependent mechanism [J]. Infect Immun, 2005; 73(1)∶632.
  22. 22. 　Porqueddu M, Spirito R, Parolari A, et al. Lack of association between serum immunoreactivity and Chlamydia pneumoniae detection in the human aortic wall [J]. Circulation, 2002; 106(21)∶2647.