目的 探討納米磁藥物靶向治療膽管移植瘤組織中凋亡相關(guān)基因caspase-3的表達(dá)。方法 建立荷人膽管癌裸鼠模型，隨機分為空白對照組、納米磁藥物組(藥物濃度為250 mg/kg)、納米磁藥物靶向A組(藥物濃度為150 mg/kg)和納米磁藥物靶向B組(藥物濃度為250 mg/kg)； 取治療后第21 d的各組腫瘤組織用免疫組化及RT-PCR法測量其中caspase-3的蛋白及mRNA表達(dá)量并進行分析。結(jié)果 納米磁藥物靶向B組中caspase-3的表達(dá)量最高,其次依次為納米磁藥物靶向A組、納米磁藥物組，空白對照組幾乎沒有caspase-3蛋白及mRNA的表達(dá)，且各組間差異均有統(tǒng)計學(xué)意義（P＜0.05)。結(jié)論 磁靶向治療腫瘤后能引起更多凋亡相關(guān)基因caspase-3表達(dá)，并且隨納米磁藥物劑量增加，caspase-3表達(dá)增多。
引用本文： 李宏,鄭建偉,唐滔,鄒聲泉. caspase-3在納米磁藥物靶向治療膽管移植瘤組織中的表達(dá). 中國普外基礎(chǔ)與臨床雜志, 2006, 13(6): 685-688. doi: 復(fù)制
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