目的 檢測組織因子（TF）在肝癌組織中的表達(dá)并探討其臨床意義。方法 采用RT-PCR方法檢測肝癌、癌旁及對照組肝組織（各27例）中TF mRNA的表達(dá)，并結(jié)合臨床病理資料進(jìn)行分析。結(jié)果 TF在肝癌組織中的表達(dá)陽性率及相對表達(dá)強度分別為62.96%（17/27）和0.567±0.268，均較癌旁組織的33.33%(9/27)和0.469±0.184及對照組肝組織的29.63%(8/27)和0.353±0.121高（P＜0.05），其相對表達(dá)強度與腫瘤大小、肝內(nèi)和肝外轉(zhuǎn)移及門靜脈癌栓有關(guān)（P＜0.05），而與患者性別、AFP、HBsAg、是否合并肝硬變、腫瘤分化程度、癌灶數(shù)目、包膜浸潤及淋巴轉(zhuǎn)移均無關(guān)(P＞0.05)。結(jié)論 TF在肝癌組織中的表達(dá)升高與部分侵襲轉(zhuǎn)移指標(biāo)有關(guān)，提示其可能參與了肝細(xì)胞癌的發(fā)生及侵襲、轉(zhuǎn)移。
引用本文： 周奇,梁力建,彭寶崗,甄宇洋. 組織因子 mRNA在肝癌患者組織中表達(dá)升高的意義. 中國普外基礎(chǔ)與臨床雜志, 2006, 13(6): 698-701. doi: 復(fù)制
| 1. | Nash GF, Walsh DC, Kakkar AK. The role of the coagulation system in tumour angiogenesis [Ｊ]. Lancet Oncol, 2001; 2(10)∶ 608. |
| 2. | Rickles FR, Shoji M, Abe K. The role of the hemostatic system in tumor growth, metastasis, and angiogenesis: tissue factor is a bifunctional molecule capable of inducing both fibrin deposition and angiogenesis in cancer [Ｊ]. Int J Hematol, 2001; 73(2)∶145. |
| 3. | Minamiya Y, Matsuzaki I, Sageshima M, et al. Expression of ti-ssue factor mRNA and invasion of blood vessels by tumor cells in non-small cell lung cancer [Ｊ]. Surg Today, 2004; 34(1)∶1. |
| 4. | Akashi T, Furuya Y, Ohta S, et al. Tissue factor expression and prognosis in patients with metastatic prostate cancer [Ｊ]. Urology, 2003; 62(6)∶1078. |
| 5. | Ishibashi H, Nakagawa K, Onimaru M, et al. Sp1 decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor, transforming growth factor beta1, and tissue factor and also cell growth and invasion activities [Ｊ]. Cancer Res, 2000; 60(22)∶6531. |
| 6. | Nakasaki T, Wada H, Shigemori C. Expression of tissue factor and vascular endothelial growth factor is associated with angiogenesis in colorectal cancer [Ｊ]. Am J Hematol, 2002; 69(4)∶247. |
| 7. | Fernandez PM, Patierno SR, Rickles FR. Tissue factor and fibrin in tumor angiogenesis [Ｊ]. Semin Thromb Hemost, 2004; 30(1)∶31. |
| 8. | Poon RT, Lau CP, Ho JW, et al. Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma [Ｊ]. Clin Cancer Res, 2003; 9(14)∶5339. |
- 1. Nash GF, Walsh DC, Kakkar AK. The role of the coagulation system in tumour angiogenesis [Ｊ]. Lancet Oncol, 2001; 2(10)∶ 608.
- 2. Rickles FR, Shoji M, Abe K. The role of the hemostatic system in tumor growth, metastasis, and angiogenesis: tissue factor is a bifunctional molecule capable of inducing both fibrin deposition and angiogenesis in cancer [Ｊ]. Int J Hematol, 2001; 73(2)∶145.
- 3. Minamiya Y, Matsuzaki I, Sageshima M, et al. Expression of ti-ssue factor mRNA and invasion of blood vessels by tumor cells in non-small cell lung cancer [Ｊ]. Surg Today, 2004; 34(1)∶1.
- 4. Akashi T, Furuya Y, Ohta S, et al. Tissue factor expression and prognosis in patients with metastatic prostate cancer [Ｊ]. Urology, 2003; 62(6)∶1078.
- 5. Ishibashi H, Nakagawa K, Onimaru M, et al. Sp1 decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor, transforming growth factor beta1, and tissue factor and also cell growth and invasion activities [Ｊ]. Cancer Res, 2000; 60(22)∶6531.
- 6. Nakasaki T, Wada H, Shigemori C. Expression of tissue factor and vascular endothelial growth factor is associated with angiogenesis in colorectal cancer [Ｊ]. Am J Hematol, 2002; 69(4)∶247.
- 7. Fernandez PM, Patierno SR, Rickles FR. Tissue factor and fibrin in tumor angiogenesis [Ｊ]. Semin Thromb Hemost, 2004; 30(1)∶31.
- 8. Poon RT, Lau CP, Ho JW, et al. Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma [Ｊ]. Clin Cancer Res, 2003; 9(14)∶5339.