• 四川大學(xué)華西醫(yī)院消化外科（成都610041）;

目的 了解細(xì)胞增殖標(biāo)記物微小染色體支持蛋白2（minichromosome maintenance protein 2，MCM2）在大腸腫瘤診斷中的應(yīng)用現(xiàn)狀。
方法復(fù)習(xí)國內(nèi)、外的文獻(xiàn)并加以綜述。
結(jié)果 MCM2在腫瘤研究中可作為評估其細(xì)胞分化發(fā)育異常和突變的指標(biāo)，細(xì)致地分析MCM2在不同大腸細(xì)胞突變階段的表達(dá)有助于早期監(jiān)測大腸細(xì)胞的突變。
結(jié)論MCM2作為一個相對敏感而特異性的細(xì)胞增殖標(biāo)記物，有望為早期臨床檢測大腸癌提供一種新的指標(biāo)，從而有助于早期診斷大腸癌，提高患者的治愈率。

引用本文： 王永,周總光,李紅光. 利用MCM2檢測細(xì)胞的增殖性在大腸腫瘤診斷中的應(yīng)用. 中國普外基礎(chǔ)與臨床雜志, 2006, 13(1): 123-124. doi: 復(fù)制

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6. Todorov IT, Werness BA, Wang HQ, et al. HsMCM2/BM28: a novel proliferation marker for human tumors and normal tissues [J]. Lab Invest， 1998; 78(1)∶73.
7. Davies RJ, Freeman A, Morris LS, et al. Analysis of minichromosome maintenance proteins as a novel method for detection of colorectal cancer in stool [J]. Lancet， 2002; 359(9321)∶1917.
8. Tan DF, Huberman JA, Hyland A, et al. MCM2——a promising marker for premalignant lesions of the lung: a cohort study [J]. BMC Cancer， 2001; 1∶6.
9. Williams GH, Romanowski P, Morris L, et al. Improved cervical smear assessment using antibodies against proteins that regulate DNA replication [J]. Proc Natl Acad Sci USA， 1998; 95(25)∶14932.
10. Gonzalez MA, Pinder SE, Callagy G, et al. Minichromosome maintenance protein 2 is a strong independent prognostic marker in breast cancer [J]. J Clin Oncol， 2003; 21(23)∶4306.
11. Freeman A, Morris LS, Mills AD, et al. Minichromosome maintenance proteins as biological markers of dysplasia and malignancy [J]. Clin Cancer Res，1999; 5(8)∶2121.
12. Going JJ, Keith WN, Neilson L, et al. Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki67 in dysplastic squamous oesophageal epithelium and Barrett’s mucosa [J]. Gut， 2002; 50(3)∶373.
13. Ramnath N, Hernandez FJ, Tan DF, et al. MCM2 is an independent predictor of survival in patients with nonsmallcell lung cancer [J]. J Clin Oncol， 2001; 19(22)∶4259.
  1. 1. Markowitz AJ, Winawer SJ. Management of colorectal polyps [J]. CA Cancer J Clin， 1997; 47(2)∶93.
  2. 2. Winawer SJ, Zauber AG, Ho MN, et al. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup [J]. N Engl J Med， 1993; 329(27)∶1977.
  3. 3. 莫善兢主編. 大腸癌臨床研究的進(jìn)展 [A]. 腫瘤學(xué)新理論與新技術(shù) [M]. 上海： 上?？萍冀逃霭嫔纾?1997∶782~788.
  4. 4. Jessup JM, Menck HR, Fremgen A, et al. Diagnosing colorectal carcinoma: clinical and molecular approaches [J]. CA Cancer J Clin， 1997; 47(2)∶70.
  5. 5. Murakami R, Tsukuma H, Kanamori S, et al. Natural history of colorectal polyps and the effect of polypectomy on occurrence of subsequent cancer [J]. Int J Cancer, 1990; 46(2)∶159.
  6. 6. Todorov IT, Werness BA, Wang HQ, et al. HsMCM2/BM28: a novel proliferation marker for human tumors and normal tissues [J]. Lab Invest， 1998; 78(1)∶73.
  7. 7. Davies RJ, Freeman A, Morris LS, et al. Analysis of minichromosome maintenance proteins as a novel method for detection of colorectal cancer in stool [J]. Lancet， 2002; 359(9321)∶1917.
  8. 8. Tan DF, Huberman JA, Hyland A, et al. MCM2——a promising marker for premalignant lesions of the lung: a cohort study [J]. BMC Cancer， 2001; 1∶6.
  9. 9. Williams GH, Romanowski P, Morris L, et al. Improved cervical smear assessment using antibodies against proteins that regulate DNA replication [J]. Proc Natl Acad Sci USA， 1998; 95(25)∶14932.
  10. 10. Gonzalez MA, Pinder SE, Callagy G, et al. Minichromosome maintenance protein 2 is a strong independent prognostic marker in breast cancer [J]. J Clin Oncol， 2003; 21(23)∶4306.
  11. 11. Freeman A, Morris LS, Mills AD, et al. Minichromosome maintenance proteins as biological markers of dysplasia and malignancy [J]. Clin Cancer Res，1999; 5(8)∶2121.
  12. 12. Going JJ, Keith WN, Neilson L, et al. Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki67 in dysplastic squamous oesophageal epithelium and Barrett’s mucosa [J]. Gut， 2002; 50(3)∶373.
  13. 13. Ramnath N, Hernandez FJ, Tan DF, et al. MCM2 is an independent predictor of survival in patients with nonsmallcell lung cancer [J]. J Clin Oncol， 2001; 19(22)∶4259.