• 【作者單位】1.四川省人民醫(yī)院乳腺外科(成都610072);;
  • 2.四川省人民醫(yī)院核醫(yī)學(xué)科;

【摘要】目的 探討99锝-tetrofosmin乳腺掃描在鑒別可捫及的乳腺包塊良惡性質(zhì)方面的價(jià)值。 方法 2000年6月至2002年1月在我院臨床發(fā)現(xiàn)乳腺包塊的104例患者接受了99锝-tetrofosmin乳腺掃描。檢查時(shí)先經(jīng)病變對(duì)側(cè)肘靜脈注射740 MBq顯像劑,注射后5、10及20 min 分別采集前位和側(cè)位圖像。距陣256×256,每幀記數(shù)1~1.5 M,將99锝-tetrofosmin在乳房局部濃聚視為親腫瘤顯像陽性。全部病例以術(shù)后病理結(jié)果為金標(biāo)準(zhǔn),以四格表進(jìn)行評(píng)價(jià)分析。 結(jié)果 99锝-tetrofosmin在對(duì)可捫及的乳腺包塊性質(zhì)進(jìn)行鑒別診斷時(shí),特異性為84%,敏感性為87%,準(zhǔn)確性為86%,陽性預(yù)測(cè)值為85%,陰性預(yù)測(cè)值為86%。 結(jié)論 99锝-tetrofosmin在對(duì)可捫及的乳腺包塊進(jìn)行良惡性質(zhì)的鑒別時(shí),不失為一種較為準(zhǔn)確的方法。

引用本文: 周蕾蕾,宋文忠,陳明曦,劉錦平,黃勁,謝紅軍,王曉東,羅 靜. 99 锝m-tetrofosmin乳腺掃描鑒別乳腺包塊性質(zhì)的臨床研究. 中國普外基礎(chǔ)與臨床雜志, 2005, 12(6): 609-611. doi: 復(fù)制

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  1. 1. 1 Kerlikowske K, Grady D, Barclay J, et al. Effect of age, breast density, and family history on the sensitivity of first screening mammography [J]. JAMA, 1996; 276(1)332 中華人民共和國衛(wèi)生部醫(yī)政司. 核醫(yī)學(xué)診斷與治療規(guī)范 [S]. 第1版.北京: 中國科學(xué)技術(shù)出版社, 1997241~2423 Taillefer R. The role of 99Tcmsestamibi and other conventional radiopharmaceuticals in breast cancer diagnosis [J]. Semin Nucl Med, 1999; 29(1)164 章斌.99mTetetrofosmin 在乳腺癌及其轉(zhuǎn)移灶顯像中的應(yīng)用[J]. 國外醫(yī)學(xué)放射醫(yī)學(xué)核醫(yī)學(xué)分冊(cè), 2001; 25(1)125 de Jong M, Bernard BF, Breeman WA, et al. Comparison of uptake of 99mTcMIBI, 99mTctetrofosmin and 99mTcQ12 into human breast cancer cell lines [J]. Eur J Nucl Med, 1996; 23(10)13616 唐謹(jǐn). 核素乳腺顯像的現(xiàn)狀和今后工作的思考 [J]. 中華核醫(yī)學(xué)雜志,1997; 17(1)697 Mansi L, Rambaldi PF, Cuccurullo V, et al. Diagnostic and prognostic role of 99mTctetrofosmin in breast cancer [J]. Q J Nucl Med, 1997; 41(3)2398 Mansi L, Rambaldi PF, Procaccini E, et al. Scintimammography with technetium99m tetrofosmin in the diagnosis of breast cancer and lymph node metastases [J]. Eur J Nucl Med, 1996; 23(8)9329 宋文忠,周蕾蕾,陳明曦,等. 99mTetetrofosmin 顯像對(duì)乳腺癌及腋窩淋巴結(jié)轉(zhuǎn)移診斷價(jià)值評(píng)價(jià) [J]. 中國醫(yī)學(xué)影像技術(shù), 2003; 19(11)153110 Obwegeser R, Berghammer P, MuellauerErtl S, et al. 99mTctetrofosmin scintigraphy for the evaluation of suspicious palpable and nonpalpable breast lesions [J]. Breast Cancer Res Treat, 2000; 62(3)253.