• 四川省腫瘤醫(yī)院（成都610041）;

目的  探討新輔助化療在晚期乳腺癌治療中的遠期臨床效果。
方法  對31例Ⅲ、Ⅳ期的乳腺癌患者行新輔助化療，手術前行2周期的CAF方案化療〔CTX 500 mg/m2靜脈推注（第1、8天）, 5-FU 500 mg/m2靜脈推注（第1、8天）,ADM 30 mg/m2靜脈推注（第1天）,每21天為1周期〕，并與同期未行任何術前治療的可手術的30例Ⅲa期患者作對比分析。
結果  新輔助化療組的總有效率為87.1%（27/31），有61.3%（19/31）的患者分期降低，其中6例降為Ⅲa期，8例降為Ⅱb期，4例降為Ⅱa期，1例降為0期，臨床完全緩解1例，無病理完全緩解。新輔助化療組的無病生存期為56.3個月，明顯高于未行化療組的43.5個月（P＜0.05），新輔助化療組的5年無病生存率為38.7%，略高于未化療組的33.3%，兩組間差異無顯著性意義。
結論  新輔助化療能降低晚期乳腺癌患者的分期，為手術創(chuàng)造最佳機會，能明顯延長晚期乳腺癌患者的無病生存期，減少或延緩腫瘤的復發(fā)、轉移。

引用本文： 李卉,廖傳貴,何小梅. 晚期乳腺癌新輔助化療的臨床報告. 中國普外基礎與臨床雜志, 2004, 11(1): 20-21. doi: 復制

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  3. 3. Gradishar WJ. Recently initiated studies: neoadjuvant treatments in the next century [Ｊ]. Semin Oncol, 1999; 26(1)∶26.
  4. 4. Sapunar F, Smith IE. Neoadjuvant chemotherapy for breast cancer [Ｊ]. Ann Med, 2000; 32(1)∶43.
  5. 5. Conte PF, Latreille J, Mauriac L, et al. Delay in progression of bone metastases in breast cancer patients treated with intravenous pamidronate: results from a multinational randomized controlled trial. The Aredia Multinational Cooperative Group [Ｊ]. J Clin Oncol, 1996; 14(9)∶2552.
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