• 福建醫(yī)科大學(xué)附屬協(xié)和醫(yī)院普外科（福州350001）;

目的探討半胱氨酸天冬氨酸蛋白酶-3（Caspase-3）的表達(dá)及其與血管瘤消退的關(guān)系。方法采用免疫組化SP法檢測Caspase-3在79例血管瘤和5例正常皮膚組織中的表達(dá)。結(jié)果79例血管瘤患者血管組織的Caspase-3陽性表達(dá)率在增殖期、消退期、退化期分別為52.4%、91.2%和83.3%，退化期、消退期的陽性表達(dá)高于增殖期（P＜0.05，P＜0.01），也明顯高于正常對照組（P＜0.01），而增殖期與正常對照組陽性表達(dá)的差異無統(tǒng)計(jì)學(xué)意義（P gt;0.05）。結(jié)論 Caspase3參與了血管瘤由增殖期轉(zhuǎn)變?yōu)橄似诘牟±戆l(fā)生過程，Caspase-3的活化誘導(dǎo)了細(xì)胞凋亡的發(fā)生，這可能是血管瘤自發(fā)消退的主要因素之一。

引用本文： 李南,陳幸生,陳大良. Caspase-3在血管瘤組織中的表達(dá)及其意義. 中國普外基礎(chǔ)與臨床雜志, 2004, 11(4): 311-313. doi: 復(fù)制

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  1. 1. Iwata J, Sonobe H, Furihata M, et al. High frequency of apoptosis in infantile capillary haemangioma [Ｊ]. J Pathol, 1996; 179(4)∶ 403.
  2. 2. Razon MJ, Kraling BM, Mulliken JB, et al. Increased apoptosis coincides with onset of involution in infantile hemangioma [Ｊ]. Microcirculation, 1998; 5(2-3)∶189.
  3. 3. Mulliken JB, Fishman SJ, Burrows PE. Vascular anomalies [Ｊ]. Curr Probl Surg, 2000; 37(8)∶517.
  4. 4. 盧曉曄， 覃莉，黃中新，等. caspase活化的細(xì)胞凋亡在非小細(xì)胞肺癌組織中的表達(dá) [Ｊ]. 實(shí)用癌癥雜志， 2002； 17（2）∶122.
  5. 5. 中華病理學(xué)雜志編輯委員會(huì). 《全國免疫組織化學(xué)技術(shù)與診斷標(biāo)準(zhǔn)化專題研討會(huì)》會(huì)議記要 [Ｊ]. 中華病理學(xué)雜志， 1996； 25（6）∶326.
  6. 6. Chang HY, Yang X. Proteases for cell suicide: functions and regulation of caspases [Ｊ]. Microbiol Mol Biol Rev, 2000; 64(4)∶821.
  7. 7. Thornberry NA, Lazebnik Y. Caspases: enemies within [Ｊ]. Science, 1998; 281(5381)∶1312.
  8. 8. Woo M, Hakem R, Soengas MS, et al. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes [Ｊ]. Genes Dev, 1998; 12(6)∶806.
  9. 9. Horky M, Wurzer G, Kotala V, et al. Segregation of nucleolar components coincides with caspase3 activation in cisplatintreated HeLa cells [Ｊ]. Journal of Cell Science, 2000; 114(Pt 4)∶663.
  10. 10. Tan ST, Velickovic M, Ruger BM, et al. Cellular and extracellular markers of hemangioma [Ｊ]. Plast Reconstr Surg, 2000; 106(3)∶529.
  11. 11. Nakagawara A, Nakamura Y, Ikeda H, et al. High levels of expression and nuclear localization of interleukin1 beta converting enzyme (ICE) and CPP32 in favorable human neuroblastomas [Ｊ].Cancer Res, 1997; 57(20)∶4578.
  12. 12. Nicholson DW. From bench to clinic with apoptosisbased therapeutic agents [Ｊ]. Nature, 2000; 407(6805)∶810.