• 重慶醫(yī)科大學(xué)附屬第一醫(yī)院血管外科（重慶400016）;

目的探討核因子-kappa B(NF-κB）在血管成形術(shù)后再狹窄中的作用。 方法對國內(nèi)、外近5年的有關(guān)文獻進行綜述。結(jié)果在血管成形術(shù)后NF-κB可引起平滑肌細胞增生及凋亡減少，導(dǎo)致血管內(nèi)膜過度增生。結(jié)論NF-κB在血管成形術(shù)后再狹窄中起著重要作用。

引用本文： 黃光斌,時德. 核因子-κB與血管成形術(shù)后再狹窄. 中國普外基礎(chǔ)與臨床雜志, 2004, 11(4): 322-324. doi: 復(fù)制

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2. Yamamoto Y, Gaynor RB. Therapeutic potential of inhibition of the NFkappaB pathway in the treatment of inflammation and cancer [J]. J Clin Invest, 2001; 107(2)∶135.
3. Bohrer H, Qiu F, Zimmermann T, et al. Role of NFkappaB in the mortality of sepsis [J]. J Clin Invest, 1997; 100(5)∶972.
4. Han Y, Weinman S, Boldogh I, et al. Tumor necrosis factoralphainducible IkappaBalpha proteolysis mediated by cytosolic mcalpain. A mechanism parallel to the ubiquitinproteasome pathway for nuclear factorkappab activation [J]. J Biol Chem, 1999; 274(2)∶787.
5. Baeuerle PA. IkappaBNFkappaB structures: at the interface of inflammation control [J]. Cell, 1998; 95(6)∶729.
6. Wang P, Wu P, Siegel MI, et al. Interleukin (IL)10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes. IL10 and IL4 suppress cytokine synthesis by different mechanisms [J]. J Biol Chem, 1995; 270(16)∶9558.
7. Maffia P, Ianaro A, Pisano B, et al. Beneficial effects of caffeic acid phenethyl ester in a rat model of vascular injury [J]. Br J Pharmacol, 2002; 136(3)∶353.
8. Ialenti A, Ianaro A, Maffia P, et al. Role of nuclear factorkappaB in a rat model of vascular injury [J]. Naunyn Schmiedebergs Arch Pharmacol, 2001; 364(4)∶343.
9. Hayashi K, Takahata H, Kitagawa N, et al. Nacetylcysteine inhibited nuclear factorkappaB expression and the intimal hyperplasia in rat carotid arterial injury [J]. Neurol Res, 2001; 23(7)∶731.
10. Aronson D. Potential role of advanced glycosylation end products in promoting restenosis in diabetes and renal failure [J]. Med Hypotheses, 2002; 59(3)∶297.
11. 李建軍，李庚山，黃從新，等. 球囊損傷兔主動脈后核因子κB活性的動態(tài)變化 [J]. 中國動脈硬化雜志， 2001； 9（1）∶34.
12. Autieri MV, Yue TL, Ferstein GZ, et al. Antisense oligonucleotides to the p65 subunit of NFkB inhibit human vascular smooth muscle cell adherence and proliferation and prevent neointima formation in rat carotid arteries [J]. Biochem Biophys Res Commun, 1995; 213(3)∶827.
13. Maruyama I, Shigeta K, Miyahara H, et al. Thrombin activates NFkappa B through thrombin receptor and results in proliferation of vascular smooth muscle cells: role of thrombin in atherosclerosis and restenosis [J]. Ann N Y Acad Sci, 1997; 811∶429.
14. Meiners S, Laule M, Rother W, et al. Ubiquitinproteasome pathway as a new target for the prevention of restenosis [J]. Circulation, 2002; 105(4)∶483.
15. Ramana KV, Chandra D, Srivastava S, et al. Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells [J]. J Biol Chem, 2002; 277(35)∶32063.
16. Erl W, Hansson GK, de Martin R, et al. Nuclear factorkappa B regulates induction of apoptosis and inhibitor of apoptosis protein1 expression in vascular smooth muscle cells [J]. Circ Res, 1999; 84(6)∶668.
17. Ibe W, Bartels W, Lindemann S, et al. Involvement of PKC and NFkappaB in nitric oxide induced apoptosis in human coronary artery smooth muscle cells [J]. Cell Physiol Biochem, 2001; 11(5)∶231.
18. Conejo R, de Alvaro C, Benito M, et al. Insulin restores differentiation of Rastransformed C2C12 myoblasts by inducing NFkappaB through an AKT/P70S6K/p38MAPK pathway [J]. Oncogene, 2002; 21(23)∶3739.
  1. 1. Kankova K, Vojtesek B, Valik D. The Rel/NFkappa B transcription factors and their biological functions [J]. Cas Lek Cesk, 2001; 140(6)∶163.
  2. 2. Yamamoto Y, Gaynor RB. Therapeutic potential of inhibition of the NFkappaB pathway in the treatment of inflammation and cancer [J]. J Clin Invest, 2001; 107(2)∶135.
  3. 3. Bohrer H, Qiu F, Zimmermann T, et al. Role of NFkappaB in the mortality of sepsis [J]. J Clin Invest, 1997; 100(5)∶972.
  4. 4. Han Y, Weinman S, Boldogh I, et al. Tumor necrosis factoralphainducible IkappaBalpha proteolysis mediated by cytosolic mcalpain. A mechanism parallel to the ubiquitinproteasome pathway for nuclear factorkappab activation [J]. J Biol Chem, 1999; 274(2)∶787.
  5. 5. Baeuerle PA. IkappaBNFkappaB structures: at the interface of inflammation control [J]. Cell, 1998; 95(6)∶729.
  6. 6. Wang P, Wu P, Siegel MI, et al. Interleukin (IL)10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes. IL10 and IL4 suppress cytokine synthesis by different mechanisms [J]. J Biol Chem, 1995; 270(16)∶9558.
  7. 7. Maffia P, Ianaro A, Pisano B, et al. Beneficial effects of caffeic acid phenethyl ester in a rat model of vascular injury [J]. Br J Pharmacol, 2002; 136(3)∶353.
  8. 8. Ialenti A, Ianaro A, Maffia P, et al. Role of nuclear factorkappaB in a rat model of vascular injury [J]. Naunyn Schmiedebergs Arch Pharmacol, 2001; 364(4)∶343.
  9. 9. Hayashi K, Takahata H, Kitagawa N, et al. Nacetylcysteine inhibited nuclear factorkappaB expression and the intimal hyperplasia in rat carotid arterial injury [J]. Neurol Res, 2001; 23(7)∶731.
  10. 10. Aronson D. Potential role of advanced glycosylation end products in promoting restenosis in diabetes and renal failure [J]. Med Hypotheses, 2002; 59(3)∶297.
  11. 11. 李建軍，李庚山，黃從新，等. 球囊損傷兔主動脈后核因子κB活性的動態(tài)變化 [J]. 中國動脈硬化雜志， 2001； 9（1）∶34.
  12. 12. Autieri MV, Yue TL, Ferstein GZ, et al. Antisense oligonucleotides to the p65 subunit of NFkB inhibit human vascular smooth muscle cell adherence and proliferation and prevent neointima formation in rat carotid arteries [J]. Biochem Biophys Res Commun, 1995; 213(3)∶827.
  13. 13. Maruyama I, Shigeta K, Miyahara H, et al. Thrombin activates NFkappa B through thrombin receptor and results in proliferation of vascular smooth muscle cells: role of thrombin in atherosclerosis and restenosis [J]. Ann N Y Acad Sci, 1997; 811∶429.
  14. 14. Meiners S, Laule M, Rother W, et al. Ubiquitinproteasome pathway as a new target for the prevention of restenosis [J]. Circulation, 2002; 105(4)∶483.
  15. 15. Ramana KV, Chandra D, Srivastava S, et al. Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells [J]. J Biol Chem, 2002; 277(35)∶32063.
  16. 16. Erl W, Hansson GK, de Martin R, et al. Nuclear factorkappa B regulates induction of apoptosis and inhibitor of apoptosis protein1 expression in vascular smooth muscle cells [J]. Circ Res, 1999; 84(6)∶668.
  17. 17. Ibe W, Bartels W, Lindemann S, et al. Involvement of PKC and NFkappaB in nitric oxide induced apoptosis in human coronary artery smooth muscle cells [J]. Cell Physiol Biochem, 2001; 11(5)∶231.
  18. 18. Conejo R, de Alvaro C, Benito M, et al. Insulin restores differentiation of Rastransformed C2C12 myoblasts by inducing NFkappaB through an AKT/P70S6K/p38MAPK pathway [J]. Oncogene, 2002; 21(23)∶3739.