• 四川大學(xué)華西醫(yī)院普外科（成都610041）;

目的  探討一氧化氮（NO）在腫瘤生長、轉(zhuǎn)移中的作用。
方法  對近年來有關(guān)文獻(xiàn)加以綜述。
結(jié)果  NO在腫瘤生長轉(zhuǎn)移中具有雙重作用，一方面NO通過干擾腫瘤細(xì)胞代謝，引起DNA損傷，形成高毒性的羥自由基，誘導(dǎo)腫瘤細(xì)胞凋亡，介導(dǎo)巨噬細(xì)胞和內(nèi)皮細(xì)胞的殺瘤作用，發(fā)揮其抗腫瘤的作用； 另一方面NO通過調(diào)節(jié)細(xì)胞增殖相關(guān)基因的表達(dá)，可誘導(dǎo)腫瘤血管形成，而具有促腫瘤生長作用。
結(jié)論  選擇性阻斷或誘導(dǎo)NO的合成，使其發(fā)揮抗腫瘤作用，將為腫瘤的治療提供新的思路和方法。

引用本文： 張劍,何生. 一氧化氮在腫瘤生長轉(zhuǎn)移中的作用. 中國普外基礎(chǔ)與臨床雜志, 2004, 11(6): 561-563. doi: 復(fù)制

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2. Fujimoto H, Ando Y, Yamashita T, et al. Nitric oxide synthase activity in human lung cancer [J]. Jpn J Cancer Res， 1997; 88(12)∶1190.
3. Thomsen LL, Miles DW, Happerfield L, et al. Nitric oxide synthase activity in human breast cancer [J]. Br J Cancer， 1995; 72(1)∶41.
4. Jenkins DC, Charles IG, Thomsen LL, et al. Roles of nitric oxide in tumor growth [J]. Proc Natl Acad Sci USA， 1995; 92(10)∶4392.
5. Yamamoto T, Terada N, Seiyama A, et al. Increase in experimental pulmonary metastasis in mice by Larginine under inhibition of nitric oxide production by NGnitroLarginine methyl ester [J]. Int J Cancer， 1998; 75(1)∶140.
6. Dong SM, Kim KM, Kim SY, et al. Frequent somatic mutations in serine/threonine kinase 11/PeutzJeghers syndrome gene in leftsided colon cancer [J]. Cancer Res， 1998; 58(17)∶3787.
7. Gallo O, Masini E, Morbidelli L, et al. Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer [J]. J Natl Cancer Inst， 1998; 90(8)∶587.
8. Teruo I, Masahiko H, Keiko K, et al. NGnitroLarginine methyl ester inbibits bone metastasis after modified intracardiac injection of human breast cancer cells in a nude mouse model [J]. Jpn J Cancer Rev， 1997; 88(6)∶801.
9. Lala PK, Orucevic A. Role of nitric oxide in tumor progression: lessons from experimental tumors [J]. Cancer Metastasis Rev， 1998; 17(1)∶91.
10. Takahashi M, Fukuda K, Ohata T, et al. Increased expression of inducible and endothelial constitutive nitric oxide synthases in rat colon tumors induced by azoxymethane [J]. Cancer Res. 1997; 57(7)∶1233.
11. Tschugguel W, Knogler W, Czerwenka K, et al. Presence of endothelial calciumdependent nitric oxide synthase in breast apocrine metaplasia [J]. Br J Cancer， 1996; 74(9)∶1423.
12. Jiang H, Stewart CA, Leu RW. Tumorderived factor synergizes with IFNgamma and LPS, IL2 or TNFalpha to promote macrophage synthesis of TNFalpha and TNF receptors for autocrine induction of nitric oxide synthase and enhanced nitric oxidemediated tumor cytotoxicity [J]. Immunobiology， 1995; 192(5)∶321.
13. Li LM, Killoun RG, Adams J, et al. Role of nitric oxide in lysis of tumor cells by cytokineactivate endothelial cells [J]. Cancer Res, 1991; 51(5)∶531.
14. Yasushi Y, Akiva M, Takash R, et al. p27 in human lung cancer: differential in smallcell and nonsmallcell carcinoma [J]. Cancer Res, 1998; 58(10)∶1042.
15. Zhang J, Dawson VL, Dawson TM, et al. Nitric oxide activation of poly (ADPribose) synthetase in neurotoxicity [J]. Science, 1994; 263(8)∶687.
16. Sagar SM, Singh G, Hodson DI, et al. Nitric oxide and anticancer therapy [J]. Cancer Treat Rev， 1995; 21(2)∶159.
17. Ho YS, Wang YJ, Lin JK. Induction of p53 and p21/WAF1/CIP1 expression by nitric oxide and their association with apoptosis in human cancer cells [J]. Mol Carcinog， 1996; 16(1)∶20.
18. Harrison DJ, Howie SEM, Wyllie AH, et al. Lymphocyte death, p53 and the problem of the “undead” cell. In: Kroemer G, Martinez AC, ed. Apoptosis in immunology [M]. Berlin: SpringVerlag, 1995∶123-128.
  1. 1. Rosbe KW, Prazma J, Petrusz P, et al. Immunohistochemical characterization of nitric oxide synthase activity in squamous cell carcinoma of the head and neck [J]. Otolaryngol Head Neck Surg, 1995; 113(5)∶541.
  2. 2. Fujimoto H, Ando Y, Yamashita T, et al. Nitric oxide synthase activity in human lung cancer [J]. Jpn J Cancer Res， 1997; 88(12)∶1190.
  3. 3. Thomsen LL, Miles DW, Happerfield L, et al. Nitric oxide synthase activity in human breast cancer [J]. Br J Cancer， 1995; 72(1)∶41.
  4. 4. Jenkins DC, Charles IG, Thomsen LL, et al. Roles of nitric oxide in tumor growth [J]. Proc Natl Acad Sci USA， 1995; 92(10)∶4392.
  5. 5. Yamamoto T, Terada N, Seiyama A, et al. Increase in experimental pulmonary metastasis in mice by Larginine under inhibition of nitric oxide production by NGnitroLarginine methyl ester [J]. Int J Cancer， 1998; 75(1)∶140.
  6. 6. Dong SM, Kim KM, Kim SY, et al. Frequent somatic mutations in serine/threonine kinase 11/PeutzJeghers syndrome gene in leftsided colon cancer [J]. Cancer Res， 1998; 58(17)∶3787.
  7. 7. Gallo O, Masini E, Morbidelli L, et al. Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer [J]. J Natl Cancer Inst， 1998; 90(8)∶587.
  8. 8. Teruo I, Masahiko H, Keiko K, et al. NGnitroLarginine methyl ester inbibits bone metastasis after modified intracardiac injection of human breast cancer cells in a nude mouse model [J]. Jpn J Cancer Rev， 1997; 88(6)∶801.
  9. 9. Lala PK, Orucevic A. Role of nitric oxide in tumor progression: lessons from experimental tumors [J]. Cancer Metastasis Rev， 1998; 17(1)∶91.
  10. 10. Takahashi M, Fukuda K, Ohata T, et al. Increased expression of inducible and endothelial constitutive nitric oxide synthases in rat colon tumors induced by azoxymethane [J]. Cancer Res. 1997; 57(7)∶1233.
  11. 11. Tschugguel W, Knogler W, Czerwenka K, et al. Presence of endothelial calciumdependent nitric oxide synthase in breast apocrine metaplasia [J]. Br J Cancer， 1996; 74(9)∶1423.
  12. 12. Jiang H, Stewart CA, Leu RW. Tumorderived factor synergizes with IFNgamma and LPS, IL2 or TNFalpha to promote macrophage synthesis of TNFalpha and TNF receptors for autocrine induction of nitric oxide synthase and enhanced nitric oxidemediated tumor cytotoxicity [J]. Immunobiology， 1995; 192(5)∶321.
  13. 13. Li LM, Killoun RG, Adams J, et al. Role of nitric oxide in lysis of tumor cells by cytokineactivate endothelial cells [J]. Cancer Res, 1991; 51(5)∶531.
  14. 14. Yasushi Y, Akiva M, Takash R, et al. p27 in human lung cancer: differential in smallcell and nonsmallcell carcinoma [J]. Cancer Res, 1998; 58(10)∶1042.
  15. 15. Zhang J, Dawson VL, Dawson TM, et al. Nitric oxide activation of poly (ADPribose) synthetase in neurotoxicity [J]. Science, 1994; 263(8)∶687.
  16. 16. Sagar SM, Singh G, Hodson DI, et al. Nitric oxide and anticancer therapy [J]. Cancer Treat Rev， 1995; 21(2)∶159.
  17. 17. Ho YS, Wang YJ, Lin JK. Induction of p53 and p21/WAF1/CIP1 expression by nitric oxide and their association with apoptosis in human cancer cells [J]. Mol Carcinog， 1996; 16(1)∶20.
  18. 18. Harrison DJ, Howie SEM, Wyllie AH, et al. Lymphocyte death, p53 and the problem of the “undead” cell. In: Kroemer G, Martinez AC, ed. Apoptosis in immunology [M]. Berlin: SpringVerlag, 1995∶123-128.