近40年來(lái),胰腺移植在基礎(chǔ)和臨床研究方面都獲得了令人振奮的長(zhǎng)足進(jìn)步。據(jù)國(guó)際胰腺移植登記中心(IPTR)記錄,全球已實(shí)施了18 900余例胰腺移植(截至2002年10月),其中絕大多數(shù)在美國(guó)(近14 000例),約90%為胰腎聯(lián)合移植(SPK)。迄今為止,SPK被公認(rèn)是治療糖尿病合并腎功能衰竭的最有效的方法。據(jù)報(bào)道,胰腺移植受體1年生存率超過(guò)95%,3年生存率接近90%; 移植胰腺有功能(患者不依賴胰島素)者的1年和3年生存率分別為83%和77%。

引用本文: 黃東勝,徐驍. 胰腎聯(lián)合移植的指征和現(xiàn)狀. 中國(guó)普外基礎(chǔ)與臨床雜志, 2003, 10(6): 528-529. doi: 復(fù)制

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  1. 1. Gruessner AC, Sutherland DE. Analysis of United States (US) and nonUS pancreas transplants reported to the United network for organ sharing (UNOS) and the international pancreas transplant registry (IPTR) as of October 2001 [J]. Clin Transpl, 2001; 41.
  2. 2. Kahl A, Bechstein WO, Frei U. Trends and perspectives in pancreas and simultaneous pancreas and kidney transplantation [J]. Curr Opin Urol, 2001; 11(2)∶165.
  3. 3. Kelly WD, Lillehei RC, Merkel FK, et al. Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy [J].Surgery, 1967; 61(6)∶827.
  4. 4. Sollinger HW, Odorico JS, Knechtle SJ, et al. Experience with 500 simultaneous pancreaskidney transplants [J]. Ann Surg, 1998; 228(3)∶284.
  5. 5. Sutherland DE, Gruessner RW, Dunn DL, et al. Lessons learned from more than 1 000 pancreas transplants at a single institution [J]. Ann Surg, 2001; 233(4)∶463.
  6. 6. Becker BN, Odorico JS, Becker YT, et al. Simultaneous pancreaskidney and pancreas transplantation [J]. J Am Soc Nephrol, 2001; 12(11)∶2517.