• 南京醫(yī)科大學(xué)第一附屬醫(yī)院普外科（南京210029）;

糖尿病是臨床常見(jiàn)病，據(jù)推測(cè)至2010年全球糖尿病患者預(yù)計(jì)將超過(guò)3.5億，其中5%～10%的患者將因糖尿病晚期出現(xiàn)的糖尿病腎病、視網(wǎng)膜病變、微血管病變和神經(jīng)末梢病變等并發(fā)癥而直接影響生命，因此糖尿病及其并發(fā)癥作為一項(xiàng)重要而艱巨的課題仍然困擾著廣大醫(yī)務(wù)工作者。胰腺移植和胰島移植能增加患者胰島素分泌細(xì)胞，從而有效地控制血糖，防止和改善糖尿病的并發(fā)癥，提高生活質(zhì)量，是治療胰島素依賴性糖尿病（IDDM）的有效手段。

引用本文： 徐澤寬,苗毅. 胰腺移植和胰島移植的現(xiàn)狀. 中國(guó)普外基礎(chǔ)與臨床雜志, 2003, 10(6): 532-534. doi: 復(fù)制

1. Odorico JS, Sollinger HW. Technical and immunosuppressive advances in transplantation for insulindependent diabetes mellitus [J]. World J Surg, 2002; 26(2)∶194.
2. Miyamoto M. Current progress and perspectives in cell therapy for diabetes mellitus [J]. Hum Cell, 2001; 14(4)∶293.
3. Kelly WD, Lillehei RC, Merkel FK, et al. Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy [J]. Surgery, 1967; 61(6)∶827.
4. Sollinger HW, Geffner SR. Pancreas transplantation [J]. Surg Clin North Am, 1994; 74(5)∶1183.
5. West M, Gruessner AC, Sutherland DE, et al. Surgical complications after conversion from bladder to enteric drainage in pancreaticoduodenal transplantation [J]. Transplant Proc, 1998; 30(2)∶438.
6. Gruessner AC, Sutherland DE. Report for the international pancreas transplant registry2000 [J]. Transplant Proc, 2001; 33(1-2)∶1643.
7. Stratta RJ, Gaber AO, ShokouhAmiri MH, et al. Evolution in pancreas transplantation techniques: simultaneous kidneypancreas transplantation using portalenteric drainage without antilymphocyte induction [J]. Ann Surg, 1999; 229(5)∶701.
8. Dawahra M, Petruzzo P, Lefrancois N, et al. Portal drainage of pancreas allograft: surgical complications and graft survival [J]. Transplant Proc, 2002; 34(3)∶817.
9. Eubanks JW, ShokouhAmiri MH, Elmer D, et al. Solitary pancreas transplantation using the portalenteric technique [J]. Transplant Proc, 1998; 30(2)∶446.
10. Kaufman DB, Leventhal JR, Koffron AJ, et al.A prospective study of rapid corticosteroid elimination in simultaneous pancreaskidney transplantation: comparison of two maintenance immunosuppression protocols: tacrolimus/mycophenolate mofetil versus tacrolimus/sirolimus [J]. Transplantation, 2002; 73(2)∶169.
11. Berney T, Buhler L, Caulfield A, et al. Transplantation of islets of Langerhans: new developments [J]. Swiss Med Wkly, 2001; 131(47-48)∶671.
12. Berney T, Ricordi C. Islet cell transplantation: the future? [J]. Langenbecks Arch Surg, 2000; 385(6)∶373.
13. Morrison CP, WemyssHolden SA, Dennison AR, et al. Islet yield remains a problem in islet autotransplantation [J]. Arch Surg, 2002; 137(1)∶80.
14. Docherty K. Growth and development of the islets of Langerhans: implications for the treatment of diabetes mellitus [J]. Curr Opin Pharmacol, 2001; 1(6)∶641.
15. Serup P, Madsen OD, MandrupPoulsen T. Islet and stem cell transplantation for treating diabetes [J]. BMJ, 2001; 322(7277)∶29.
16. Zeng Y, Ricordi C, Lendoire J, et al. The effect of prednisone on pancreatic islet autografts in dogs [J]. Surgery, 1993; 113(1)∶98.
17. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoidfree immunosuppressive regimen [J]. N Engl J Med, 2000; 343(4)∶230.
18. BonnerWeir S, Taneja M, Weir GC, et al. In vitro cultivation of human islets from expanded ductal tissue [J]. Proc Natl Acad Sci USA, 2000; 97(14)∶7999.
19. Ramiya VK, Maraist M, Arfors KE. Reversal of insulindependent diabetes using islets generated in vitro from pancreatic stem cells [J]. Nat Med, 2000; 6(3)∶278.
20. Soria B, Roche E, Berna G, et al. Insulinsecreting cells derived from embryonic stem cells normalize glycemia in streptozotocininduced diabetic mice [J]. Diabetes, 2000; 49(2)∶157.
  1. 1. Odorico JS, Sollinger HW. Technical and immunosuppressive advances in transplantation for insulindependent diabetes mellitus [J]. World J Surg, 2002; 26(2)∶194.
  2. 2. Miyamoto M. Current progress and perspectives in cell therapy for diabetes mellitus [J]. Hum Cell, 2001; 14(4)∶293.
  3. 3. Kelly WD, Lillehei RC, Merkel FK, et al. Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy [J]. Surgery, 1967; 61(6)∶827.
  4. 4. Sollinger HW, Geffner SR. Pancreas transplantation [J]. Surg Clin North Am, 1994; 74(5)∶1183.
  5. 5. West M, Gruessner AC, Sutherland DE, et al. Surgical complications after conversion from bladder to enteric drainage in pancreaticoduodenal transplantation [J]. Transplant Proc, 1998; 30(2)∶438.
  6. 6. Gruessner AC, Sutherland DE. Report for the international pancreas transplant registry2000 [J]. Transplant Proc, 2001; 33(1-2)∶1643.
  7. 7. Stratta RJ, Gaber AO, ShokouhAmiri MH, et al. Evolution in pancreas transplantation techniques: simultaneous kidneypancreas transplantation using portalenteric drainage without antilymphocyte induction [J]. Ann Surg, 1999; 229(5)∶701.
  8. 8. Dawahra M, Petruzzo P, Lefrancois N, et al. Portal drainage of pancreas allograft: surgical complications and graft survival [J]. Transplant Proc, 2002; 34(3)∶817.
  9. 9. Eubanks JW, ShokouhAmiri MH, Elmer D, et al. Solitary pancreas transplantation using the portalenteric technique [J]. Transplant Proc, 1998; 30(2)∶446.
  10. 10. Kaufman DB, Leventhal JR, Koffron AJ, et al.A prospective study of rapid corticosteroid elimination in simultaneous pancreaskidney transplantation: comparison of two maintenance immunosuppression protocols: tacrolimus/mycophenolate mofetil versus tacrolimus/sirolimus [J]. Transplantation, 2002; 73(2)∶169.
  11. 11. Berney T, Buhler L, Caulfield A, et al. Transplantation of islets of Langerhans: new developments [J]. Swiss Med Wkly, 2001; 131(47-48)∶671.
  12. 12. Berney T, Ricordi C. Islet cell transplantation: the future? [J]. Langenbecks Arch Surg, 2000; 385(6)∶373.
  13. 13. Morrison CP, WemyssHolden SA, Dennison AR, et al. Islet yield remains a problem in islet autotransplantation [J]. Arch Surg, 2002; 137(1)∶80.
  14. 14. Docherty K. Growth and development of the islets of Langerhans: implications for the treatment of diabetes mellitus [J]. Curr Opin Pharmacol, 2001; 1(6)∶641.
  15. 15. Serup P, Madsen OD, MandrupPoulsen T. Islet and stem cell transplantation for treating diabetes [J]. BMJ, 2001; 322(7277)∶29.
  16. 16. Zeng Y, Ricordi C, Lendoire J, et al. The effect of prednisone on pancreatic islet autografts in dogs [J]. Surgery, 1993; 113(1)∶98.
  17. 17. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoidfree immunosuppressive regimen [J]. N Engl J Med, 2000; 343(4)∶230.
  18. 18. BonnerWeir S, Taneja M, Weir GC, et al. In vitro cultivation of human islets from expanded ductal tissue [J]. Proc Natl Acad Sci USA, 2000; 97(14)∶7999.
  19. 19. Ramiya VK, Maraist M, Arfors KE. Reversal of insulindependent diabetes using islets generated in vitro from pancreatic stem cells [J]. Nat Med, 2000; 6(3)∶278.
  20. 20. Soria B, Roche E, Berna G, et al. Insulinsecreting cells derived from embryonic stem cells normalize glycemia in streptozotocininduced diabetic mice [J]. Diabetes, 2000; 49(2)∶157.