目的探討環(huán)氧化酶-2（COX-2）和血管內(nèi)皮生長因子（VEGF）在胰腺癌組織中的表達及與其生物學(xué)行為的相關(guān)性。方法采用免疫組織化學(xué)Envision法對51例胰腺導(dǎo)管癌組織中COX-2和VEGF的表達進行檢測。結(jié)果該51例胰腺導(dǎo)管癌組織中COX-2和VEGF的表達陽性率分別為74.5%和68.6%，而二者在11例癌旁胰腺組織中均未見陽性表達； COX-2和VEGF的表達陽性率在臨床Ⅲ～Ⅳ期明顯高于臨床Ⅰ～Ⅱ期，淋巴結(jié)轉(zhuǎn)移陽性組明顯高于淋巴結(jié)轉(zhuǎn)移陰性組，其差異均有顯著性意義（P＜0.05）； COX-2和VEGF的表達與胰腺癌的組織學(xué)分級、患者的性別、年齡以及腫瘤的大小和部位無關(guān)（P gt;0.05）； COX-2的表達與VEGF的表達呈正相關(guān)（r=0.411, P＜0.01）。結(jié)論COX-2和VEGF可能在胰腺癌的發(fā)生、發(fā)展過程中起著關(guān)鍵性作用，二者在血管生成過程中密切相關(guān)，可能為胰腺癌的治療提供新的靶點，值得深入探討。
引用本文： 劉江偉,李開宗,竇科峰. 環(huán)氧化酶-2和血管內(nèi)皮生長因子在胰腺癌組織中的表達及其相關(guān)性研究. 中國普外基礎(chǔ)與臨床雜志, 2003, 10(6): 539-541. doi: 復(fù)制
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- 2. Kloppel G. Pancreatic non-endocrine tumors. In: Kloppel G. Heitz (eds). Pancreatic pathology [M]. Edinburg, Scotand: Churchill Livingstone, 1984∶79.
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- 4. Molina MA, SitjaArnau M, Lemoine MG, et al. Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal antiinflammatory drugs [Ｊ]. Cancer Res, 1999; 59(17)∶4356.
- 5. Ikeda N, Nakajima Y, Sho M, et al. The association of K-ras gene mutation and vascular endothelial growth factor gene expression in pancreatic carcinoma [Ｊ]. Cancer, 2001; 92(3)∶488.
- 6. Ristimaki A, Sivula A, Lundin J, et al. Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer [Ｊ].Cancer Res, 2002; 62(3)∶632.
- 7. Costa C, Soares R, ReisFilho JS, et al. Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer [Ｊ].J Clin Pathol, 2002; 55(6)∶429.
- 8. 李繼坤， 鄭淼， 李遠芳， 等. p53及VEGF表達與結(jié)、直腸癌血道轉(zhuǎn)移發(fā)生的關(guān)系 [Ｊ]. 中國普外基礎(chǔ)與臨床雜志， 2002； 9（2）∶112.
- 9. Niedergethmann M, Hildenbrand R, Wostbrock B, et al. High expression of vascular endothelial growth factor predicts early recurrence and poor prognosis after curative resection for ductal adenocarcinoma of the pancreas [Ｊ]. Pancreas, 2002; 25(2)∶122.
- 10. Seno H, Oshima M, Ishikawa TO, et al. Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta 716) mouse intestinal polyps [Ｊ]. Cancer Res, 2002; 62(2)∶506.