• 四川大學(xué)華西醫(yī)院普外科（成都610041）;

目的探討5氟脲嘧啶（5FU）對(duì)人胰腺外分泌功能的影響。方法通過(guò)8例胰十二腸切除術(shù)后患者胰管內(nèi)置管獲得的純胰液觀察5FU對(duì)人胰腺外分泌功能的作用。術(shù)后第10天開(kāi)始，靜脈緩慢滴注5FU 500 mg/d,連續(xù)3天。檢測(cè)5FU使用前和使用后1 d、 2 d及3 d胰液中淀粉酶、 pH、 HCO3-、 Na+、 K+、 Cl-、 Ca2+及Mg2+水平，并記錄胰液量變化。結(jié)果使用5FU前、后胰液量及胰液中淀粉酶、 pH、 HCO3-、 Na+、 K+、 Cl-、 Ca2+及Mg2+水平均無(wú)顯著變化。結(jié)論短期內(nèi)使用5FU對(duì)胰腺外分泌功能未見(jiàn)明顯影響，5FU是否通過(guò)抑制胰酶的合成治療急性胰腺炎有待進(jìn)一步探討。

引用本文： 蔣力生,姚有貴,彭其芳. 5氟脲嘧啶對(duì)胰腺外分泌的影響. 中國(guó)普外基礎(chǔ)與臨床雜志, 2003, 10(3): 266-267. doi: 復(fù)制

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  1. 1. Johnson RM, Barone RM, Newson BL,et al. Treatment of experimental acute pancreatitis with 5Fluorouracil (5FU) [J]. Am J Surg, 1973; 125(2)∶211.
  2. 2. Bielecki K, Wiedmann M, Meyer F,et al. Effect of 5Fluorouracil on secretion and synthesis of pancreatic digestive enzymes: studies in isolated pancreatic acini and perfused pancreas derived from normal rats and from rats with acute necrotizing pancreatitis [Ｊ]. Pancreas, 1994; 9(4)∶518.
  3. 3. Steinberg WM, Schlesselman SE. Treatment of acute pancreatitis. Comparison of animal and human studies [Ｊ]. Gastroenterology, 1987; 93(6)∶1420.
  4. 4. Niederau C, Niederau M, Luthen R,et al. Pancreatic exocrine secretion in acute experimental pancreatitis [Ｊ]. Gastroenterology, 1990; 99(4)∶1120.
  5. 5. 陳曉理，黃興蘭，吳浩，等. 5FU對(duì)急性胰腺炎炎癥相關(guān)細(xì)胞因子的調(diào)節(jié)作用 [Ｊ].中華外科雜志，2001; 39(4)∶271.
  6. 6. 陳曉理，黃興蘭，吳浩，等. 常用免疫抑制劑對(duì)急性胰腺炎免疫異常的調(diào)節(jié)作用 [Ｊ].中國(guó)普外基礎(chǔ)與臨床雜志，2002; 9(6)∶384.