目的探討生長(zhǎng)激素應(yīng)用于全身炎癥反應(yīng)綜合征時(shí)二胺氧化酶（DAO）和內(nèi)毒素（ET）水平的變化及其與腸粘膜屏障損傷的關(guān)系。方法將146例嚴(yán)重感染性疾病合并全身炎癥反應(yīng)綜合征患者分為非手術(shù)組和手術(shù)組兩組，再分別將此兩組隨機(jī)分為治療組及對(duì)照組，于治療前及治療后 1周監(jiān)測(cè)血漿DAO和ET水平。結(jié)果治療組血漿DAO及ET水平在治療后較治療前下降，且差異有顯著性意義（P＜0.05，P＜0.01）。結(jié)論生長(zhǎng)激素對(duì)嚴(yán)重感染性疾病合并全身炎癥反應(yīng)綜合征患者的腸粘膜屏障具有一定的保護(hù)作用。
引用本文： 王琛,王彤,李徐生. 生長(zhǎng)激素應(yīng)用于全身炎癥反應(yīng)綜合征時(shí)二胺氧化酶及內(nèi)毒素變化的臨床意義. 中國普外基礎(chǔ)與臨床雜志, 2003, 10(3): 270-271. doi: 復(fù)制
| 1. | Thompson JS, Vaughan WP, Forst CF, et al. The effect of the route of nutrient delivery on gut structure and diamine oxidase levels [J]. JPEN J Parenter Enteral Nutr, 1987; 11(1)∶28. |
| 2. | Deitch EA, Sittig K, Li M, et al. Obstructive jaundice promotes bacterial translocation from the gut [Ｊ]. Am J Surg, 1990; 159(1)∶79. |
| 3. | Deitch EA. Bacterial translocation of the gut flora [Ｊ]. J Trauma, 1990; 30(12 Suppl)∶S184. |
| 4. | Kazantsev GB, Hecht DW, Rao R, et al. Plasmid labeling confirms bacterial translocation in pancreatitis [Ｊ]. Am J Surg, 1994; 167(1)∶201. |
| 5. | GomezdeSegura IA, Prieto I, Grande AG, et al. Growth hormone reduces mortality and bacterial translocation in irradiated rats [Ｊ]. Acta Oncol, 1998; 37(2)∶179. |
| 6. | 何桂珍,蔣朱明. 重組生長(zhǎng)激素對(duì)創(chuàng)傷后代謝的影響 [Ｊ]. 中華醫(yī)學(xué)雜志, 1995; 75(5)∶312. |
| 7. | 蔣朱明, 何桂珍, 張思源, 等. 手術(shù)后患者用生長(zhǎng)激素及腸外營養(yǎng)的代謝效應(yīng) [Ｊ]. 中華外科雜志, 1995; 33(11)∶704. |
| 8. | 王彤, 姜秀峰, 王琛, 等. 重組人生長(zhǎng)激素對(duì)梗阻性黃疸作用的實(shí)驗(yàn)研究 [Ｊ]. 中國普外基礎(chǔ)與臨床雜志, 2002; 9(6)∶408. |
- 1. Thompson JS, Vaughan WP, Forst CF, et al. The effect of the route of nutrient delivery on gut structure and diamine oxidase levels [J]. JPEN J Parenter Enteral Nutr, 1987; 11(1)∶28.
- 2. Deitch EA, Sittig K, Li M, et al. Obstructive jaundice promotes bacterial translocation from the gut [Ｊ]. Am J Surg, 1990; 159(1)∶79.
- 3. Deitch EA. Bacterial translocation of the gut flora [Ｊ]. J Trauma, 1990; 30(12 Suppl)∶S184.
- 4. Kazantsev GB, Hecht DW, Rao R, et al. Plasmid labeling confirms bacterial translocation in pancreatitis [Ｊ]. Am J Surg, 1994; 167(1)∶201.
- 5. GomezdeSegura IA, Prieto I, Grande AG, et al. Growth hormone reduces mortality and bacterial translocation in irradiated rats [Ｊ]. Acta Oncol, 1998; 37(2)∶179.
- 6. 何桂珍,蔣朱明. 重組生長(zhǎng)激素對(duì)創(chuàng)傷后代謝的影響 [Ｊ]. 中華醫(yī)學(xué)雜志, 1995; 75(5)∶312.
- 7. 蔣朱明, 何桂珍, 張思源, 等. 手術(shù)后患者用生長(zhǎng)激素及腸外營養(yǎng)的代謝效應(yīng) [Ｊ]. 中華外科雜志, 1995; 33(11)∶704.
- 8. 王彤, 姜秀峰, 王琛, 等. 重組人生長(zhǎng)激素對(duì)梗阻性黃疸作用的實(shí)驗(yàn)研究 [Ｊ]. 中國普外基礎(chǔ)與臨床雜志, 2002; 9(6)∶408.