目的介紹1995年國際肝病工作組關(guān)于肝硬變結(jié)節(jié)的分類標(biāo)準(zhǔn),總結(jié)與病理學(xué)特征相關(guān)的各種肝結(jié)節(jié)的影像學(xué)表現(xiàn),并探討各種影像學(xué)檢查方法的診斷價(jià)值。方法用超聲、CT、MRI、血管造影性CT等各種影像學(xué)檢查方法。結(jié)果在肝硬變背景基礎(chǔ)上肝癌的發(fā)生、發(fā)展,沿循從再生結(jié)節(jié)、低度非典型性結(jié)節(jié)、高度非典型性結(jié)節(jié)到小肝癌(SHCC)、大肝癌的逐步演進(jìn)過程,在此過程中同時(shí)伴有結(jié)節(jié)內(nèi)血流供應(yīng)和灌注的相應(yīng)變化。結(jié)論現(xiàn)代影像學(xué)檢查技術(shù)的發(fā)展為肝內(nèi)各種結(jié)節(jié)的檢出、定性和鑒別診斷提供了多種十分有效的方法,為各類肝結(jié)節(jié),特別是早期小肝癌結(jié)節(jié)的診斷、治療創(chuàng)造了有利條件。
引用本文: 吳苾,宋彬. 肝硬變結(jié)節(jié)性病變的影像學(xué)和相關(guān)病理學(xué)表現(xiàn). 中國普外基礎(chǔ)與臨床雜志, 2003, 10(3): 288-294. doi: 復(fù)制
版權(quán)信息: ?四川大學(xué)華西醫(yī)院華西期刊社《中國普外基礎(chǔ)與臨床雜志》版權(quán)所有,未經(jīng)授權(quán)不得轉(zhuǎn)載、改編
1. | International Working Party. Terminology of nodular hepatocellular lesions [J]. Hepatology, 1995; 22(3)∶ 983. |
2. | 周曉軍. 肝臟交界性病變的病理組織學(xué)特點(diǎn) [J]. 中華病理學(xué)雜志,2001; 30(3)∶ 222. |
3. | Krinsky G. Terminology of hepatocellular nodules in cirrhosis: plea for consistency [J]. Radiology, 2002; 224(3)∶ 638. |
4. | Hussain SM, Zondervan PE, IJzermans JN, et al. Benign versus malignant hepatic nodules: MR imaging findings with pathologic correlation [J]. Radiographics, 2002; 22(5)∶ 1023. |
5. | Choi BI. Hepatocarcinogenesis in liver cirrhosis: imaging diagnosis [J]. J Korean Med Sci, 1998; 13(2)∶ 103. |
6. | Lim JH,Choi BI. Dysplastic nodules in liver cirrhosis: imaging [J]. Abdom Imaging, 2002; 27(2)∶ 117. |
7. | Matsui O, Kadoya M, Kameyama T, et al. Benign and malignant nodules in cirrhotic livers: distinction based on blood supply [J]. Radiology, 1991; 178(2)∶ 493. |
8. | Matsui O, Ueda K, Kobayashi S, et al. Intra and perinodular hemodynamics of hepatocellular carcinoma: CT observation during intraarterial contrast injection [J]. Abdom Imaging, 2002; 27(2)∶ 147. |
9. | Hayashi M, Matsui O, Ueda K, et al. Progression to hypervascular hepatocellular carcinoma: correlation with intranodular blood supply evaluated with CT during intraarterial injection of contrast material [J]. Radiology, 2002; 225(1)∶ 143. |
10. | Roncalli M, Roz E,Coggi G, et al. The vascular profile of regenerative and dysplastic nodules of the cirrhotic liver: implications for diagnosis and classification [J]. Hepatology, 1999; 30(5)∶ 1174. |
11. | Horton KM, Bluemke DA, Hruban RH, et al. CT and MR imaging of benign hepatic and biliary tumors [J]. Radiographics, 1999; 19(2)∶ 431. |
12. | 李肅,徐堅(jiān)民,單軍. 肝局灶結(jié)節(jié)樣增生MR、CT表現(xiàn)(附6例報(bào)告) [J]. 實(shí)用放射學(xué)雜志,2001; 17(4)∶ 281. |
13. | Mathieu D, Bruneton JN, Drouilard J, et al. Hepatic adenomas and focal nodular hyperplasia: dynamic CT study [J]. Radiology, 1986; 160(1)∶ 53. |
14. | Takayasu K, Furukawa H, Wakao F, et al. CT diagnosis of early hepatocellular carcinoma: sensitivity, findings, and CTpathologic correlation [J]. AJR Am J Roentgenol, 1995; 164(4)∶ 885. |
15. | Itoh Y, Akamatsu K. Relationships between echo lever and histological characteristics in small hepatocellular carcinomas [J]. J Clin Ultrasound, 1998; 26(6)∶ 295. |
16. | 李傳福,劉松濤,馬祥興.螺旋CT多期增強(qiáng)掃描對(duì)小肝癌的診斷 [J]. 山東醫(yī)科大學(xué)學(xué)報(bào),2000; 38(4)∶ 403. |
17. | Zhou K,Yan F,Tu B. Evaluation of the arterial phase of biphasic enhanced SCT in the diagnosis of small HCC [J]. Zhonghua Ganzangbing Zazhi, 1999; 7(3)∶ 135. |
18. | 王薇.三種檢查方法聯(lián)合早期發(fā)現(xiàn)肝細(xì)胞癌的臨床意義 [J]. 實(shí)用放射學(xué)雜志, 2000; 16(8)∶ 496. |
19. | Rode A,Bancel B,Douek P, et al. Small nodule detection in cirrhotic livers: evaluation with US, spiral CT, and MRI and correlation with pathologic examination of explanted liver [J]. J Comput Assist Tomogr, 2001; 25(3)∶ 327. |
20. | 楊海山,張宇,張惠茅.US、CT、MRI和DSA診斷原發(fā)性肝癌的比較研究 [J]. 中國醫(yī)學(xué)影像學(xué)雜志, 2001; 9(1)∶ 70. |
21. | Murakami T, Kim T, Takahashi S, et al. Hepatocellular carcinoma: multidetector row helical CT [J]. Abdom Imaging, 2002; 27(2)∶ 139. |
22. | Yu JS,Kim MJ.Hepatocellular carcinoma: contrastenhanced MRI [J].Abdom Imaging, 2002; 27(2)∶ 157. |
- 1. International Working Party. Terminology of nodular hepatocellular lesions [J]. Hepatology, 1995; 22(3)∶ 983.
- 2. 周曉軍. 肝臟交界性病變的病理組織學(xué)特點(diǎn) [J]. 中華病理學(xué)雜志,2001; 30(3)∶ 222.
- 3. Krinsky G. Terminology of hepatocellular nodules in cirrhosis: plea for consistency [J]. Radiology, 2002; 224(3)∶ 638.
- 4. Hussain SM, Zondervan PE, IJzermans JN, et al. Benign versus malignant hepatic nodules: MR imaging findings with pathologic correlation [J]. Radiographics, 2002; 22(5)∶ 1023.
- 5. Choi BI. Hepatocarcinogenesis in liver cirrhosis: imaging diagnosis [J]. J Korean Med Sci, 1998; 13(2)∶ 103.
- 6. Lim JH,Choi BI. Dysplastic nodules in liver cirrhosis: imaging [J]. Abdom Imaging, 2002; 27(2)∶ 117.
- 7. Matsui O, Kadoya M, Kameyama T, et al. Benign and malignant nodules in cirrhotic livers: distinction based on blood supply [J]. Radiology, 1991; 178(2)∶ 493.
- 8. Matsui O, Ueda K, Kobayashi S, et al. Intra and perinodular hemodynamics of hepatocellular carcinoma: CT observation during intraarterial contrast injection [J]. Abdom Imaging, 2002; 27(2)∶ 147.
- 9. Hayashi M, Matsui O, Ueda K, et al. Progression to hypervascular hepatocellular carcinoma: correlation with intranodular blood supply evaluated with CT during intraarterial injection of contrast material [J]. Radiology, 2002; 225(1)∶ 143.
- 10. Roncalli M, Roz E,Coggi G, et al. The vascular profile of regenerative and dysplastic nodules of the cirrhotic liver: implications for diagnosis and classification [J]. Hepatology, 1999; 30(5)∶ 1174.
- 11. Horton KM, Bluemke DA, Hruban RH, et al. CT and MR imaging of benign hepatic and biliary tumors [J]. Radiographics, 1999; 19(2)∶ 431.
- 12. 李肅,徐堅(jiān)民,單軍. 肝局灶結(jié)節(jié)樣增生MR、CT表現(xiàn)(附6例報(bào)告) [J]. 實(shí)用放射學(xué)雜志,2001; 17(4)∶ 281.
- 13. Mathieu D, Bruneton JN, Drouilard J, et al. Hepatic adenomas and focal nodular hyperplasia: dynamic CT study [J]. Radiology, 1986; 160(1)∶ 53.
- 14. Takayasu K, Furukawa H, Wakao F, et al. CT diagnosis of early hepatocellular carcinoma: sensitivity, findings, and CTpathologic correlation [J]. AJR Am J Roentgenol, 1995; 164(4)∶ 885.
- 15. Itoh Y, Akamatsu K. Relationships between echo lever and histological characteristics in small hepatocellular carcinomas [J]. J Clin Ultrasound, 1998; 26(6)∶ 295.
- 16. 李傳福,劉松濤,馬祥興.螺旋CT多期增強(qiáng)掃描對(duì)小肝癌的診斷 [J]. 山東醫(yī)科大學(xué)學(xué)報(bào),2000; 38(4)∶ 403.
- 17. Zhou K,Yan F,Tu B. Evaluation of the arterial phase of biphasic enhanced SCT in the diagnosis of small HCC [J]. Zhonghua Ganzangbing Zazhi, 1999; 7(3)∶ 135.
- 18. 王薇.三種檢查方法聯(lián)合早期發(fā)現(xiàn)肝細(xì)胞癌的臨床意義 [J]. 實(shí)用放射學(xué)雜志, 2000; 16(8)∶ 496.
- 19. Rode A,Bancel B,Douek P, et al. Small nodule detection in cirrhotic livers: evaluation with US, spiral CT, and MRI and correlation with pathologic examination of explanted liver [J]. J Comput Assist Tomogr, 2001; 25(3)∶ 327.
- 20. 楊海山,張宇,張惠茅.US、CT、MRI和DSA診斷原發(fā)性肝癌的比較研究 [J]. 中國醫(yī)學(xué)影像學(xué)雜志, 2001; 9(1)∶ 70.
- 21. Murakami T, Kim T, Takahashi S, et al. Hepatocellular carcinoma: multidetector row helical CT [J]. Abdom Imaging, 2002; 27(2)∶ 139.
- 22. Yu JS,Kim MJ.Hepatocellular carcinoma: contrastenhanced MRI [J].Abdom Imaging, 2002; 27(2)∶ 157.