• 四川大學(xué)華西醫(yī)院普外科（成都610041）;

目的了解選擇素在急性胰腺炎發(fā)病及病程進(jìn)展中的作用，為進(jìn)一步研究提供方向，指導(dǎo)臨床治療實(shí)踐。 方法綜述選擇素在急性胰腺炎時(shí)的病理生理作用機(jī)理。 結(jié)果選擇素水平在急性胰腺炎過(guò)程中有明顯變化，并與細(xì)胞因子、氧自由基、補(bǔ)體等密切相關(guān)。 結(jié)論選擇素是急性胰腺炎病理機(jī)理的組成部分，其表達(dá)水平對(duì)臨床疾病的觀察及治療有指導(dǎo)意義。

引用本文： 王存,綜述,周總光,審校. 選擇素與急性胰腺炎. 中國(guó)普外基礎(chǔ)與臨床雜志, 2003, 10(3): 309-310. doi: 復(fù)制

1. 7KylanpaaBack ML, Takala A, Kemppainen EA, et al. Procalcitonin, soluble interleukin2 receptor, and soluble Eselectin in predicting the severity of acute pancreatitis [J]. Crit Care Med, 2001; 29(1)∶63.
2. Petruzzelli L, Takami M, Humes HD. Structure and function of cell adhesion molecules [J]. Am J Med, 1999; 106(4)∶467.
3. 鄭立新,周曉紅,石應(yīng)康,等. 選擇素研究進(jìn)展 [J]. 生物醫(yī)學(xué)工程學(xué)雜志, 2000; 17(1)∶101.
4. Fassbender K, Kaptur S, Becker P, et al. Adhesion molecules in tissue injury: kinetics of expression and shedding and association with cytokine release in humans [J]. Clin Immunol Immunopathol, 1998; 89(1)∶54.
5. Lundberg AH, Granger DN, Russell J, et al. Quantitative measurement of P and Eselectin adhesion molecules in acute pancreatitis: correlation with distant organ injury [J]. Ann Surg, 2000; 231(2)∶213.
6. Blann AD, Lip GY. Hypothesis: is soluble Pselectin a new marker of platelet activation? [J]. Atherosclerosis, 1997; 128(2)∶135.
7. Powell JJ, Siriwardena AK, Fearon KC, et al. Endothelialderived selectins in the development of organ dysfunction in acute pancreatitis [J]. Crit Care Med, 2001; 29(3)∶567.
8. 秦仁義，裘法祖. 炎癥介質(zhì)、細(xì)胞因子在急性壞死性胰腺炎發(fā)生、發(fā)展中的作用 [J]. 中國(guó)普外基礎(chǔ)與臨床雜志， 1998； 5（6）∶361.
9. Springer TA. Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration [J]. Annu Rev Physiol, 1995; 57∶827.
10. Hughes CB, Gaber LW, Mohey elDin AB, et al. Inhibition of TNF alpha improves survival in an experimental model of acute pancreatitis [J]. Am Surg, 1996; 62(1)∶ 8.
11. Folch E, Salas A, Panes J, et al. Role of Pselectin and ICAM1 in pancreatitisinduced lung inflammation in rats: significance of oxidative stress [J]. Ann Surg, 1999; 230(6)∶792.
12. Telek G, Ducroc R, Scoazec JY, et al. Differential upregulation of cellular adhesion molecules at the sites of oxidative stress in experimental acute pancreatitis [J]. J Surg Res, 2001; 96(1)∶56.
13. Hartwig W, Jimenez RE, Fernandezdel Castillo C, et al. Expression of the adhesion molecules Mac1 and Lselectin on neutrophils in acute pancreatitis is protease and complementdependent [J]. Ann Surg, 2001; 233(3)∶371.
14. Folch E, Prats N, Hotter G, et al. Pselectin expression and Kupffer cell activation in rat acute pancreatitis [J]. Dig Dis Sci, 2000; 45(8)∶1535.
15. Folch E, Salas A, Prats N, et al. H2O2 and PARS mediate lung Pselectin upregulation in acute pancreatitis [J]. Free Radic Biol Med, 2000; 28(8)∶1286.
16. Norman JG, Franz MG, Fink GS, et al. Decreased mortality of severe acute pancreatitis after proximal cytokine blockade [J]. Ann Surg, 1995; 221(6)∶625.
  1. 1. 7KylanpaaBack ML, Takala A, Kemppainen EA, et al. Procalcitonin, soluble interleukin2 receptor, and soluble Eselectin in predicting the severity of acute pancreatitis [J]. Crit Care Med, 2001; 29(1)∶63.
  2. 2. Petruzzelli L, Takami M, Humes HD. Structure and function of cell adhesion molecules [J]. Am J Med, 1999; 106(4)∶467.
  3. 3. 鄭立新,周曉紅,石應(yīng)康,等. 選擇素研究進(jìn)展 [J]. 生物醫(yī)學(xué)工程學(xué)雜志, 2000; 17(1)∶101.
  4. 4. Fassbender K, Kaptur S, Becker P, et al. Adhesion molecules in tissue injury: kinetics of expression and shedding and association with cytokine release in humans [J]. Clin Immunol Immunopathol, 1998; 89(1)∶54.
  5. 5. Lundberg AH, Granger DN, Russell J, et al. Quantitative measurement of P and Eselectin adhesion molecules in acute pancreatitis: correlation with distant organ injury [J]. Ann Surg, 2000; 231(2)∶213.
  6. 6. Blann AD, Lip GY. Hypothesis: is soluble Pselectin a new marker of platelet activation? [J]. Atherosclerosis, 1997; 128(2)∶135.
  7. 7. Powell JJ, Siriwardena AK, Fearon KC, et al. Endothelialderived selectins in the development of organ dysfunction in acute pancreatitis [J]. Crit Care Med, 2001; 29(3)∶567.
  8. 8. 秦仁義，裘法祖. 炎癥介質(zhì)、細(xì)胞因子在急性壞死性胰腺炎發(fā)生、發(fā)展中的作用 [J]. 中國(guó)普外基礎(chǔ)與臨床雜志， 1998； 5（6）∶361.
  9. 9. Springer TA. Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration [J]. Annu Rev Physiol, 1995; 57∶827.
  10. 10. Hughes CB, Gaber LW, Mohey elDin AB, et al. Inhibition of TNF alpha improves survival in an experimental model of acute pancreatitis [J]. Am Surg, 1996; 62(1)∶ 8.
  11. 11. Folch E, Salas A, Panes J, et al. Role of Pselectin and ICAM1 in pancreatitisinduced lung inflammation in rats: significance of oxidative stress [J]. Ann Surg, 1999; 230(6)∶792.
  12. 12. Telek G, Ducroc R, Scoazec JY, et al. Differential upregulation of cellular adhesion molecules at the sites of oxidative stress in experimental acute pancreatitis [J]. J Surg Res, 2001; 96(1)∶56.
  13. 13. Hartwig W, Jimenez RE, Fernandezdel Castillo C, et al. Expression of the adhesion molecules Mac1 and Lselectin on neutrophils in acute pancreatitis is protease and complementdependent [J]. Ann Surg, 2001; 233(3)∶371.
  14. 14. Folch E, Prats N, Hotter G, et al. Pselectin expression and Kupffer cell activation in rat acute pancreatitis [J]. Dig Dis Sci, 2000; 45(8)∶1535.
  15. 15. Folch E, Salas A, Prats N, et al. H2O2 and PARS mediate lung Pselectin upregulation in acute pancreatitis [J]. Free Radic Biol Med, 2000; 28(8)∶1286.
  16. 16. Norman JG, Franz MG, Fink GS, et al. Decreased mortality of severe acute pancreatitis after proximal cytokine blockade [J]. Ann Surg, 1995; 221(6)∶625.