• 中南大學(xué)湘雅二醫(yī)院肝膽疾病研究室（長沙410011）;

目的 探討胰腺良、惡性病變組織中HOX A9 mRNA的表達(dá)及其臨床意義。方法采用常規(guī)石蠟包埋切片，HOX A9 mRNA原位雜交檢測，對53例胰腺癌及20例慢性胰腺炎手術(shù)切除標(biāo)本進(jìn)行對比研究。結(jié)果胰腺癌組HOX A9 mRNA表達(dá)陽性率和評分〔49%，（3.3±2.1）分〕均明顯低于慢性胰腺炎組〔95%，（5.4±0.8）分〕和癌旁上皮組〔80%，（4.6±1.2）分，n=25〕，而且其差異均有顯著性（P＜0.01）； 慢性胰腺炎組和癌旁上皮組HOX A9 mRNA表達(dá)陰性（n=5）病例的導(dǎo)管上皮均呈中至重度不典型增生； 高分化腺癌（n=30）和未轉(zhuǎn)移癌（n=22）的HOX A9 mRNA表達(dá)陽性率及其評分分別為63%，（4.0±2.2）分和64%，（4.1±2.2）分，均明顯高于低分化腺癌〔32%，（2.6±2.3）分，n=19〕和轉(zhuǎn)移癌〔32%，（2.7±2.2）分，n=25〕，其差異也有顯著性意義（P＜0.05或P＜0.01）。結(jié)論該研究結(jié)果提示，HOX A9 mRNA表達(dá)可能與胰腺癌的發(fā)生、發(fā)展、生物學(xué)行為及預(yù)后有密切關(guān)系，檢測胰腺良、惡性病變組織中HOX A9 mRNA的表達(dá)，對預(yù)防和早期發(fā)現(xiàn)胰腺癌可能具有重要的臨床意義，值得深入研究。

引用本文： 王群偉,楊竹林,苗雄鷹,劉國利,李永國. 胰腺良惡性疾病中HOX A9 mRNA的表達(dá)及其臨床意義. 中國普外基礎(chǔ)與臨床雜志, 2003, 10(4): 373-375. doi: 復(fù)制

版權(quán)信息： ?四川大學(xué)華西醫(yī)院華西期刊社《中國普外基礎(chǔ)與臨床雜志》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編

1. Golpon HA, Geraci MW, Moore MD, et al.Hox genes in human lung: altered expression in primary pulmonary hypertension and emphysema [J]. Am J Pathol, 2001; 158(3)∶ 955.
2. Raman V, Martensen SA, Reisman D, et al. Compromised HOX A5 function can limit p53 expression in human breast tumours [J]. Nature, 2000; 405(6789)∶974.
3. Cillo C, Cantile M, Faiella A, et al. Homeobox genes in normal and malignant cells [J]. J Cell Physiol, 2001; 188( 2) ∶161.
4. Li H, Huang CJ, Choo KB. Expression of homeobox genes in cervical cancer [J]. Gynecol Oncol, 2002; 84(2)∶ 216.
5. 胡淳玲，喻倫銀，陳德基, 等. 大鼠試驗(yàn)性肺鱗癌癌變各階段間質(zhì)微血管密度及VEGF、FLK1表達(dá)的動態(tài)變化 [J]. 癌癥， 2001; 20(10)∶713.
6. Pando SM, Taylor HS. Homeobox gene expression in ovarian cancer [J]. Cancer Treat Res, 2002; 107∶231.
7. Afonja O, Smith JE Jr, Cheng DM, et al. MEISI and HOXA7 genes in man acute myeloid leukemia [J]. Leuk Res, 2000; 24(10)∶849.
8. Wang Y, Hung C, Koh D, et al. Differential expression of HOX A5 in human colon cancer cell differentiation: a quantitative study using realtime RTPCR [J]. Int J Oncol, 2001; 18(3)∶617.
  1. 1. Golpon HA, Geraci MW, Moore MD, et al.Hox genes in human lung: altered expression in primary pulmonary hypertension and emphysema [J]. Am J Pathol, 2001; 158(3)∶ 955.
  2. 2. Raman V, Martensen SA, Reisman D, et al. Compromised HOX A5 function can limit p53 expression in human breast tumours [J]. Nature, 2000; 405(6789)∶974.
  3. 3. Cillo C, Cantile M, Faiella A, et al. Homeobox genes in normal and malignant cells [J]. J Cell Physiol, 2001; 188( 2) ∶161.
  4. 4. Li H, Huang CJ, Choo KB. Expression of homeobox genes in cervical cancer [J]. Gynecol Oncol, 2002; 84(2)∶ 216.
  5. 5. 胡淳玲，喻倫銀，陳德基, 等. 大鼠試驗(yàn)性肺鱗癌癌變各階段間質(zhì)微血管密度及VEGF、FLK1表達(dá)的動態(tài)變化 [J]. 癌癥， 2001; 20(10)∶713.
  6. 6. Pando SM, Taylor HS. Homeobox gene expression in ovarian cancer [J]. Cancer Treat Res, 2002; 107∶231.
  7. 7. Afonja O, Smith JE Jr, Cheng DM, et al. MEISI and HOXA7 genes in man acute myeloid leukemia [J]. Leuk Res, 2000; 24(10)∶849.
  8. 8. Wang Y, Hung C, Koh D, et al. Differential expression of HOX A5 in human colon cancer cell differentiation: a quantitative study using realtime RTPCR [J]. Int J Oncol, 2001; 18(3)∶617.