目的 探討胰腺良、惡性病變組織中HOX A9 mRNA的表達(dá)及其臨床意義。方法采用常規(guī)石蠟包埋切片，HOX A9 mRNA原位雜交檢測，對53例胰腺癌及20例慢性胰腺炎手術(shù)切除標(biāo)本進(jìn)行對比研究。結(jié)果胰腺癌組HOX A9 mRNA表達(dá)陽性率和評分〔49%，（3.3±2.1）分〕均明顯低于慢性胰腺炎組〔95%，（5.4±0.8）分〕和癌旁上皮組〔80%，（4.6±1.2）分，n=25〕，而且其差異均有顯著性（P＜0.01）； 慢性胰腺炎組和癌旁上皮組HOX A9 mRNA表達(dá)陰性（n=5）病例的導(dǎo)管上皮均呈中至重度不典型增生； 高分化腺癌（n=30）和未轉(zhuǎn)移癌（n=22）的HOX A9 mRNA表達(dá)陽性率及其評分分別為63%，（4.0±2.2）分和64%，（4.1±2.2）分，均明顯高于低分化腺癌〔32%，（2.6±2.3）分，n=19〕和轉(zhuǎn)移癌〔32%，（2.7±2.2）分，n=25〕，其差異也有顯著性意義（P＜0.05或P＜0.01）。結(jié)論該研究結(jié)果提示，HOX A9 mRNA表達(dá)可能與胰腺癌的發(fā)生、發(fā)展、生物學(xué)行為及預(yù)后有密切關(guān)系，檢測胰腺良、惡性病變組織中HOX A9 mRNA的表達(dá)，對預(yù)防和早期發(fā)現(xiàn)胰腺癌可能具有重要的臨床意義，值得深入研究。
引用本文： 王群偉,楊竹林,苗雄鷹,劉國利,李永國. 胰腺良惡性疾病中HOX A9 mRNA的表達(dá)及其臨床意義. 中國普外基礎(chǔ)與臨床雜志, 2003, 10(4): 373-375. doi: 復(fù)制
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