• 中國(guó)協(xié)和醫(yī)科大學(xué)北京協(xié)和醫(yī)院基本外科(北京100730);

手術(shù)野感染(surgical site infection, SSI)是外科手術(shù)的并發(fā)癥之一。為預(yù)防和減少SSI,采用了不少措施: 提高空氣的潔凈度,良好的患者皮膚準(zhǔn)備和腸道準(zhǔn)備,治療已存在的感染灶,提高術(shù)中防護(hù),減少術(shù)中污染。預(yù)防性抗生素的使用是重要措施之一。多年實(shí)踐證明,預(yù)防性抗生素使用,可以減低SSI發(fā)生率。近來(lái)預(yù)防性抗生素使用已近乎成為常規(guī)了,抗生素用量迅速增長(zhǎng)。但如何使用預(yù)防性抗生素在臨床上缺乏統(tǒng)一的認(rèn)識(shí)與規(guī)范。

引用本文: 唐偉松. 外科預(yù)防性抗生素的應(yīng)用. 中國(guó)普外基礎(chǔ)與臨床雜志, 2002, 9(1): 6-7. doi: 復(fù)制

版權(quán)信息: ?四川大學(xué)華西醫(yī)院華西期刊社《中國(guó)普外基礎(chǔ)與臨床雜志》版權(quán)所有,未經(jīng)授權(quán)不得轉(zhuǎn)載、改編

1. Page CP, Bohnen JMA, Fletcher JR, et al. Antimicrobial prophylaxis for surgical wounds. Guidelines for clinical care [J]. Arch Surg, 1993; 128(1)∶79.
2. Kaiser AB. Antimicrobial prophylaxis in surgery [J]. N Engl J Med, 1986; 315(18)∶1129.
3. Cainzos MA. Antibiotic prophylaxis [J].New Horizons, 1998; 6(2 Suppl)∶S11.
4. Alexander JW, Altemeier WA. Penicillin prophylaxis of experimental staphylococal woud infections [J].Surg Gynecol Obstet, 1965; 120(2)∶243.
5. Velasco E,Thuler LCS, Martins CAS, et al.Risk factors for infection complications after abdominal surgery for malignant disease [J].Am J Infect Cont, 1996; 24(1)∶1.
6. Kreisel D, Savel TG, Silver AL, et al. Surgical antibiotic prophylaxis and clostridium difficile toxin positivity [J]. Arch Surg, 1995; 130(9)∶989.
7. Lewis RT, Weigand FM, Mamazza J, et al. Should antibiotic prophylaxis be used routinely in clean surgical procedure: a tentative yes [J]. Surgery, 1995; 118(4)∶742.
8. Taylor EW, Byrne DJ, Leaper DJ,et al. Antibiotic prophylaxis and open groin hernia repair [J]. World J Surg, 1997; 21(8)∶811.
9. 唐偉松,李小毅,楊志英,等. 預(yù)防性抗生素在普外科手術(shù)中的應(yīng)用 [J].中華普通外科雜志,2001; 16(7)∶445.
10. Plett R, Zaleznik DF, Hopkins CC,et al.Perioperative antibiotic prophylaxis for herniorrhaphy and breast surgery [J]. N Engl J Med, 1990; 322(3)∶153.
11. Illig KA, Schmidt E, Gavanaugh J, et al.Are prophylactic antibiotics required for elective laparoscopic cholecystectomy [J]? J Am Coll Surg, 1997; 184(4)∶353.
12. Song F, Glenny AM. Antimicrobial propylaxis in colorectal surgery: a systematic review of randomized controlled trials [J]. Br J Surg, 1998; 85(9)∶1232.
13. Classen DC,Evans RS, Pestonik SL, et al. The timing of prophyactic administration of antibiotics and the risk of surgicalwound infection [J].N Engl J Med, 1992; 326(5)∶281.
14. Tang TM, Tam PK, Saing H. Antibiotic prophylaxis in acute nonperforated appendicitis in children: single dose of metronidazole and gentamycin [J]. J R Coll Surg Edinb, 1992; 37(2)∶110.
15. Swoboda SM, Merz C,Kostuik J, et al. Does intraoperative blood loss affect antibiotic serum and tissue concentrations [J]? Arch Surg, 1996; 131(11)∶1165.
16. 楊志英,唐偉松.腹部手術(shù)應(yīng)用短程抗生素預(yù)防手術(shù)區(qū)感染的療效分析 [J].中華外科雜志,2001; 39(10)∶770.
17. 劉玉村,高付生,萬(wàn)遠(yuǎn)廉,等. 結(jié)腸手術(shù)預(yù)防應(yīng)用頭孢三嗪的臨床研究和實(shí)驗(yàn)研究 [J]. 中華外科雜志, 1998; 增刊∶25.
  1. 1. Page CP, Bohnen JMA, Fletcher JR, et al. Antimicrobial prophylaxis for surgical wounds. Guidelines for clinical care [J]. Arch Surg, 1993; 128(1)∶79.
  2. 2. Kaiser AB. Antimicrobial prophylaxis in surgery [J]. N Engl J Med, 1986; 315(18)∶1129.
  3. 3. Cainzos MA. Antibiotic prophylaxis [J].New Horizons, 1998; 6(2 Suppl)∶S11.
  4. 4. Alexander JW, Altemeier WA. Penicillin prophylaxis of experimental staphylococal woud infections [J].Surg Gynecol Obstet, 1965; 120(2)∶243.
  5. 5. Velasco E,Thuler LCS, Martins CAS, et al.Risk factors for infection complications after abdominal surgery for malignant disease [J].Am J Infect Cont, 1996; 24(1)∶1.
  6. 6. Kreisel D, Savel TG, Silver AL, et al. Surgical antibiotic prophylaxis and clostridium difficile toxin positivity [J]. Arch Surg, 1995; 130(9)∶989.
  7. 7. Lewis RT, Weigand FM, Mamazza J, et al. Should antibiotic prophylaxis be used routinely in clean surgical procedure: a tentative yes [J]. Surgery, 1995; 118(4)∶742.
  8. 8. Taylor EW, Byrne DJ, Leaper DJ,et al. Antibiotic prophylaxis and open groin hernia repair [J]. World J Surg, 1997; 21(8)∶811.
  9. 9. 唐偉松,李小毅,楊志英,等. 預(yù)防性抗生素在普外科手術(shù)中的應(yīng)用 [J].中華普通外科雜志,2001; 16(7)∶445.
  10. 10. Plett R, Zaleznik DF, Hopkins CC,et al.Perioperative antibiotic prophylaxis for herniorrhaphy and breast surgery [J]. N Engl J Med, 1990; 322(3)∶153.
  11. 11. Illig KA, Schmidt E, Gavanaugh J, et al.Are prophylactic antibiotics required for elective laparoscopic cholecystectomy [J]? J Am Coll Surg, 1997; 184(4)∶353.
  12. 12. Song F, Glenny AM. Antimicrobial propylaxis in colorectal surgery: a systematic review of randomized controlled trials [J]. Br J Surg, 1998; 85(9)∶1232.
  13. 13. Classen DC,Evans RS, Pestonik SL, et al. The timing of prophyactic administration of antibiotics and the risk of surgicalwound infection [J].N Engl J Med, 1992; 326(5)∶281.
  14. 14. Tang TM, Tam PK, Saing H. Antibiotic prophylaxis in acute nonperforated appendicitis in children: single dose of metronidazole and gentamycin [J]. J R Coll Surg Edinb, 1992; 37(2)∶110.
  15. 15. Swoboda SM, Merz C,Kostuik J, et al. Does intraoperative blood loss affect antibiotic serum and tissue concentrations [J]? Arch Surg, 1996; 131(11)∶1165.
  16. 16. 楊志英,唐偉松.腹部手術(shù)應(yīng)用短程抗生素預(yù)防手術(shù)區(qū)感染的療效分析 [J].中華外科雜志,2001; 39(10)∶770.
  17. 17. 劉玉村,高付生,萬(wàn)遠(yuǎn)廉,等. 結(jié)腸手術(shù)預(yù)防應(yīng)用頭孢三嗪的臨床研究和實(shí)驗(yàn)研究 [J]. 中華外科雜志, 1998; 增刊∶25.