• 重慶醫(yī)科大學(xué)第一附屬醫(yī)院血管外科（重慶400016）;

目的  探討血清可溶性CD14(sCD14）、E-選擇素、白細(xì)胞介素-10（IL-10）、腫瘤壞死因子-α（TNF-α）和平均動(dòng)脈壓（MAP）在內(nèi)毒素血癥病理變化過(guò)程中的水平及其相互關(guān)系。
方法  復(fù)制兔內(nèi)毒素血癥模型，分別于模型制作后0 min、30 min、60 min、120 min、180 min、240 min及300 min取血測(cè)定E-選擇素、IL-10、sCD14及TNF-α含量，同時(shí)八導(dǎo)生理記錄儀記錄MAP。
結(jié)果  內(nèi)毒素血癥組中TNF-α及sCD14含量30 min后即開(kāi)始增加； E-選擇素和IL-10含量120 min后明顯增加； MAP則于120 min后明顯下降。對(duì)照組中各指標(biāo)水平變化不明顯。
結(jié)論  sCD14、TNF-α、E-選擇素及IL-10在內(nèi)毒素血癥的發(fā)病機(jī)理中起著重要的作用。sCD14和TNF-α是反映感染病理變化早期過(guò)程中的重要指標(biāo)之一； E-選擇素和IL-10可能與該病理變化的嚴(yán)重程度有關(guān)。

引用本文： 楊鏞,時(shí)德. 兔內(nèi)毒素血癥時(shí)sCD14、E-選擇素和IL-10水平及其與預(yù)后的關(guān)系. 中國(guó)普外基礎(chǔ)與臨床雜志, 2002, 9(1): 10-12. doi: 復(fù)制

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4. Bevilacqua MP, Stengelin S, Gimbrane MA, et al. Endothelial leukocyte adhesion molecule1: an inducible receptor for new trophils related to complement regulatory protein and lectin [Ｊ]. Science, 1989; 243(12)∶ 1160.
5. Bogdan C, Vodovota Y, Nathan C. Macrophage deactivation by interleukin10 [Ｊ]. J Exp Med, 1991; 174(9)∶1549.
6. Hickey MJ, Issekutz AC, Reinhardt PH, et al. Endogenous interleukin10 regulates hemodynamic parameters, leukocyteendothelial cell interactions, and microvascular permeability during endotoxemia [Ｊ]. Cir Res, 1998; 83(10)∶1124.
7. Gerard C, Bruyns C, Marchant A, et al. Interleukin10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia [Ｊ]. J Exp Med, 1993; 177(3)∶547.
8. Mayadas TN, Johnson RC, Rayburn H, et al. Leukocyte rolling and extravasation are severely comproised in Pselectindeficient mice [Ｊ]. Cell, 1993; 74(4)∶541.
  1. 1. 黃青青，楊鏞，萬(wàn)林駿，等.復(fù)方丹滲注射液對(duì)兔內(nèi)毒素休克的防治作用 [Ｊ]. 中國(guó)危重病急救醫(yī)學(xué)，1998； 10（4）∶ 227.
  2. 2. Haziot A, Rong GW, Bazil V, et al. Recombinant soluble CD14 inhibits LPSinduced tumor necrosis factorα production by cells in whole blood [Ｊ]. J Immunol, 1994; 152(11)∶5868.
  3. 3. Haziot A, Rong GW, Lin XY, et al. Recombinant soluble CD14 prevents mortality in mice treated with endotoxin (Lipopolysaccharide) [Ｊ]. J Immunol, 1994; 152(12)∶6529.
  4. 4. Bevilacqua MP, Stengelin S, Gimbrane MA, et al. Endothelial leukocyte adhesion molecule1: an inducible receptor for new trophils related to complement regulatory protein and lectin [Ｊ]. Science, 1989; 243(12)∶ 1160.
  5. 5. Bogdan C, Vodovota Y, Nathan C. Macrophage deactivation by interleukin10 [Ｊ]. J Exp Med, 1991; 174(9)∶1549.
  6. 6. Hickey MJ, Issekutz AC, Reinhardt PH, et al. Endogenous interleukin10 regulates hemodynamic parameters, leukocyteendothelial cell interactions, and microvascular permeability during endotoxemia [Ｊ]. Cir Res, 1998; 83(10)∶1124.
  7. 7. Gerard C, Bruyns C, Marchant A, et al. Interleukin10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia [Ｊ]. J Exp Med, 1993; 177(3)∶547.
  8. 8. Mayadas TN, Johnson RC, Rayburn H, et al. Leukocyte rolling and extravasation are severely comproised in Pselectindeficient mice [Ｊ]. Cell, 1993; 74(4)∶541.