目的 研究p53及血管內(nèi)皮細胞生長因子（vascular endothelial growth factor, VEGF）表達與結、直腸癌血道轉移發(fā)生的關系。方法應用免疫組織化學ABC法檢測79例結、直腸癌組織中p53及VEGF的表達。 結果p53和VEGF在結、直腸癌組織中表達陽性率分別為48.1%和58.2%； 62.0%的病例中p53和VEGF表達一致。p53及VEGF表達與結、直腸癌靜脈侵犯、血道轉移密切相關（P＜0.05），p53及VEGF陽性表達組血道轉移發(fā)生率為66.7%，明顯高于p53及VEGF陰性表達組和p53陽性表達、VEGF陰性表達組（P＜0.01）； p53及VEGF陰性表達病例中，無同時性或異時性血道轉移發(fā)生。結論結合分析p53及VEGF表達狀態(tài)，對預測結、直腸癌血道轉移的發(fā)生有重要參考價值。
引用本文： 李繼坤,鄭淼,李遠芳,陳忠偉. p53及VEGF表達與結、直腸癌血道轉移發(fā)生的關系. 中國普外基礎與臨床雜志, 2002, 9(2): 112-114. doi: 復制
| 1. | Maeda K, Chung YS, Ogawa Y, et al. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma \[J\]. Cancer, 1996; 77(5)∶858. |
| 2. | Takahashi Y, Bueana CD, Cleary KR, et al. p53, vessel count,and vascular endothelial growth factor expression in human colon cancer \[J\]. Int J Cancer,1998; 79(1)∶34. |
| 3. | Yoshiji H, Gomez DE, Shibuya M, et al. Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer \[J\]. Cancer Res, 1996; 56(9)∶2013. |
| 4. | Porter PL, Gown AM. p53 expression in human malignant tumors \[J\]. Am J Pathol, 1992; 140(1)∶145. |
| 5. | Goh HS, Yao J, Smith DR. p53 point mutation and survival in colorectal cancer patients \[J\]. Cancer Res, 1995; 55(22)∶5217. |
| 6. | Yamamura T, Matsuzaki H, Suda T, et al. Clinicopathological variables and p53 overexpression as a combined prognosticator for hematogenic recurrence in colorectal cancer \[J\]. J Surg Oncol, 1999; 70(1)∶1. |
| 7. | Kieser A, Weich HA, Brandner G, et al. Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression \[J\]. Oncogene, 1994; 9(3)∶963. |
| 8. | Steele RJC, Thompson AM, Hall PA, et al. The p53 tumour suppressor gene \[J\]. Br J Surg, 1998; 85(11)∶1460. |
- 1. Maeda K, Chung YS, Ogawa Y, et al. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma \[J\]. Cancer, 1996; 77(5)∶858.
- 2. Takahashi Y, Bueana CD, Cleary KR, et al. p53, vessel count,and vascular endothelial growth factor expression in human colon cancer \[J\]. Int J Cancer,1998; 79(1)∶34.
- 3. Yoshiji H, Gomez DE, Shibuya M, et al. Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer \[J\]. Cancer Res, 1996; 56(9)∶2013.
- 4. Porter PL, Gown AM. p53 expression in human malignant tumors \[J\]. Am J Pathol, 1992; 140(1)∶145.
- 5. Goh HS, Yao J, Smith DR. p53 point mutation and survival in colorectal cancer patients \[J\]. Cancer Res, 1995; 55(22)∶5217.
- 6. Yamamura T, Matsuzaki H, Suda T, et al. Clinicopathological variables and p53 overexpression as a combined prognosticator for hematogenic recurrence in colorectal cancer \[J\]. J Surg Oncol, 1999; 70(1)∶1.
- 7. Kieser A, Weich HA, Brandner G, et al. Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression \[J\]. Oncogene, 1994; 9(3)∶963.
- 8. Steele RJC, Thompson AM, Hall PA, et al. The p53 tumour suppressor gene \[J\]. Br J Surg, 1998; 85(11)∶1460.