• 1.上海市第一人民醫(yī)院外科（上海200080）;;
  • 2.復(fù)旦大學(xué)醫(yī)學(xué)院腫瘤醫(yī)院病理科（上海200032）;

目的 研究p53及血管內(nèi)皮細(xì)胞生長(zhǎng)因子（vascular endothelial growth factor, VEGF）表達(dá)與結(jié)、直腸癌血道轉(zhuǎn)移發(fā)生的關(guān)系。方法應(yīng)用免疫組織化學(xué)ABC法檢測(cè)79例結(jié)、直腸癌組織中p53及VEGF的表達(dá)。 結(jié)果p53和VEGF在結(jié)、直腸癌組織中表達(dá)陽性率分別為48.1%和58.2%； 62.0%的病例中p53和VEGF表達(dá)一致。p53及VEGF表達(dá)與結(jié)、直腸癌靜脈侵犯、血道轉(zhuǎn)移密切相關(guān)（P＜0.05），p53及VEGF陽性表達(dá)組血道轉(zhuǎn)移發(fā)生率為66.7%，明顯高于p53及VEGF陰性表達(dá)組和p53陽性表達(dá)、VEGF陰性表達(dá)組（P＜0.01）； p53及VEGF陰性表達(dá)病例中，無同時(shí)性或異時(shí)性血道轉(zhuǎn)移發(fā)生。結(jié)論結(jié)合分析p53及VEGF表達(dá)狀態(tài)，對(duì)預(yù)測(cè)結(jié)、直腸癌血道轉(zhuǎn)移的發(fā)生有重要參考價(jià)值。

引用本文： 李繼坤,鄭淼,李遠(yuǎn)芳,陳忠偉. p53及VEGF表達(dá)與結(jié)、直腸癌血道轉(zhuǎn)移發(fā)生的關(guān)系. 中國(guó)普外基礎(chǔ)與臨床雜志, 2002, 9(2): 112-114. doi: 復(fù)制

版權(quán)信息： ?四川大學(xué)華西醫(yī)院華西期刊社《中國(guó)普外基礎(chǔ)與臨床雜志》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編

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  4. 4. Porter PL, Gown AM. p53 expression in human malignant tumors \[J\]. Am J Pathol, 1992; 140(1)∶145.
  5. 5. Goh HS, Yao J, Smith DR. p53 point mutation and survival in colorectal cancer patients \[J\]. Cancer Res, 1995; 55(22)∶5217.
  6. 6. Yamamura T, Matsuzaki H, Suda T, et al. Clinicopathological variables and p53 overexpression as a combined prognosticator for hematogenic recurrence in colorectal cancer \[J\]. J Surg Oncol, 1999; 70(1)∶1.
  7. 7. Kieser A, Weich HA, Brandner G, et al. Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression \[J\]. Oncogene, 1994; 9(3)∶963.
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