• 沈陽軍區(qū)總醫(yī)院普外科（沈陽110015）;

目的探討激素與肝再生的關(guān)系。方法收集和復習近年的有關(guān)文獻。結(jié)果激素與肝再生的關(guān)系十分密切，參與肝再生的過程，起促進或抑制肝再生的作用。結(jié)論激素是調(diào)節(jié)肝再生的重要因素之一。

引用本文： 張雪峰,綜述,宗修錕,審校. 激素與肝臟再生. 中國普外基礎(chǔ)與臨床雜志, 2002, 9(2): 136-138. doi: 復制

1. Knopp J, Brtko J, Jezova D, et al. Partial hepatectomy alters serum hormone levels in rats \[J\]. Horm Metab Res，1991; 23(7)∶329.
2. Oren R, Dabeva MD, Karnezis AN, et al. Role of thyroid hormone in stimulating liver repopulation in the rat by transplanted hepatocytes \[J\]. Hepatology，1999; 30(4)∶903.
3. Knopp J, Hudecova S. Expression of S14 protein gene in rat liver in response to partial hepatectomy, and its regulation with T3 and sucrose \[J\]. J Lipid Mediat Cell Signa，1995; 11(3)∶253.
4. Obata T,Cheng SY. Regulation by thyroid hormone of the synthesis of a cytosolic thyroid hormone binding protein during liver regeneration \[J\]. Biochem Biophys Res Commun，1992; 189(1)∶257.
5. Goupil D, Ethier C, Zarnegar R, et al. Hepatic expression of regeneration maker genes following partial hepatectomy in the rat. Influence of 1,25dihydroxyvitamin D3 in hypocalcemia \[J\]. J Hepatol，1997; 26(3)∶659.
6. Rixon RH, Isaacs RJ,Whitfield JF.Control of DNA polymerasealpha activity in regenerating rat liver by calcium and 1 alpha, 25 (OH)2 D3 \[J\]. J Cell Physiol，1989; 139(2)∶354.
7. Ethier C, Goupil D, Demers C, et al. Hypocalcemia, regardless of the vitamin D status，decreases epidermal growth factor receptor density and autophosphorylation in rat livers \[J\]. Endocrinology，1993; 133(2)∶780.
8. Ethier C, Kestekian R, Beaulieu C, et al. Vitamin D depletion retards the normal regeneration process after partial hepatectomy in the rat \[J\]. Endocrinology，1990; 126(6)∶2947.
9. Shimada M, Matsumata T, Yamamoto K, et al.The role of growth hormone, somatostatin and glucagon in hepatic resection \[J\]. Hepatogastroenterology，1998; 45(19)∶178.
10. Baruch Y, Amit T, Hertz P, et al. Growth hormonebinding protein in partially hepatectomized rats \[J\]. Horm Res，1993; 40(5-6)∶173.
11. Asakawa K, Hizuka N, Takano K,et al. Human growth hormone stimulates liver regeneration in rats \[J\]. J Endocrinol Invest，1989;12(5)∶343.
12. Ekberg S, Luther M, Nakamura J, et al. Growth hormone promotes early initiation of hepatocyte growth factor gene expression in the liver of hypophysectomized rats after partial hepatectomy \[J\]. J Endocrinol，1992; 135(1)∶59.
13. Buckley AR, Crowe PD, Bauman PA, et al. Prolactinprovoked alterations of cytosolic, membrane, and nuclear protein kinase C following partial hepatectomy \[J\]. Dig Dis Sci，1991; 36(9)∶1313.
14. Francavilla A, Eagon PK, Dileo A, et al. Sex hormonerelated functions in regenerating male rat liver \[J\]. Gastroenterology，1986; 91(5)∶1263.
15. Francavilla A, Gavaler JS, Makowka L, et al. Estradiol and testosterone levels in patients undergoing partial hepatectomy. A possible signal for hepatic regeneration \[J\]. Dig Dis Sci，1989; 34(6)∶818.
16. Starzl TE, Francavilla A, Halgrimson CG, et al. The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood \[J\]. Surg Gynecol Obstet, 1973; 137(2)∶179.
17. Fujiwara K, Ogata I, Sato Y, et al. Insulin and glucagon therapy of acute hepatic failure \[J\]. Dig Dis Sci，1991; 36(6)∶809.
18. Lai HS, Chung YC, Chen WJ, et al. Rat liver regeneration after partial hepatectomy：effects of insulin, glucagon and epidermal growth factor \[J\]. J Formos Med Assoc，1992;91(7)∶685.
19. Barbason H, Bouzahzah B, Herens C, et al. Circadian synchronization of liver regeneration in adult rats： the role plaged by adrenal hormones \[J\]. Cell Tissue Kinet，1989; 22(6)∶451.
20. Krasil’nikov MA, Bogdanova NN, Adler VV. Inhibition of proliferation of normal and neoplastic liver cell under conditions of prolonged hormonal stimulation \[J\]. Biokhimiia，1989; 54(4)∶656.
21. Hatta S. Influence of plasma hormone levels on various stimulantinduced hepatic DNA synthesis in carbon tetrachorideintoxicated rats \[J\]. Jpn J Pharmacol，1985; 37(1)∶77.
22. Hasegawa K, Kar S, Carr BI. Stimulation of hepatocyte DNA synthesis by neurotensin \[J\]. J Cell Physiol，1994; 158(2)∶215.
23. Rasmussen TN, Jorgensen PE, Almdal T, et al. Effect of gastrin in liver regeneration after partial hepatectomy in rats \[J\]. Gut，1990; 31(1)∶92.
24. VanThiel DH, Stauber R, Gavaler JS, et al. Hepatic regeneration. Effects of age, sex hormone status, prolactin, and cyclosporine \[J\]. Dig Dis Sci，1991; 36(9)∶1309.
25. Kahn D, Gavaler JS, Lai H, et al. Effect of cyclosporine on hepatic cytosolic estrogen and androgen receptor levels before and after partial hepatectomy \[J\]. Dig Dis Sci，1990; 35(1)∶6.
  1. 1. Knopp J, Brtko J, Jezova D, et al. Partial hepatectomy alters serum hormone levels in rats \[J\]. Horm Metab Res，1991; 23(7)∶329.
  2. 2. Oren R, Dabeva MD, Karnezis AN, et al. Role of thyroid hormone in stimulating liver repopulation in the rat by transplanted hepatocytes \[J\]. Hepatology，1999; 30(4)∶903.
  3. 3. Knopp J, Hudecova S. Expression of S14 protein gene in rat liver in response to partial hepatectomy, and its regulation with T3 and sucrose \[J\]. J Lipid Mediat Cell Signa，1995; 11(3)∶253.
  4. 4. Obata T,Cheng SY. Regulation by thyroid hormone of the synthesis of a cytosolic thyroid hormone binding protein during liver regeneration \[J\]. Biochem Biophys Res Commun，1992; 189(1)∶257.
  5. 5. Goupil D, Ethier C, Zarnegar R, et al. Hepatic expression of regeneration maker genes following partial hepatectomy in the rat. Influence of 1,25dihydroxyvitamin D3 in hypocalcemia \[J\]. J Hepatol，1997; 26(3)∶659.
  6. 6. Rixon RH, Isaacs RJ,Whitfield JF.Control of DNA polymerasealpha activity in regenerating rat liver by calcium and 1 alpha, 25 (OH)2 D3 \[J\]. J Cell Physiol，1989; 139(2)∶354.
  7. 7. Ethier C, Goupil D, Demers C, et al. Hypocalcemia, regardless of the vitamin D status，decreases epidermal growth factor receptor density and autophosphorylation in rat livers \[J\]. Endocrinology，1993; 133(2)∶780.
  8. 8. Ethier C, Kestekian R, Beaulieu C, et al. Vitamin D depletion retards the normal regeneration process after partial hepatectomy in the rat \[J\]. Endocrinology，1990; 126(6)∶2947.
  9. 9. Shimada M, Matsumata T, Yamamoto K, et al.The role of growth hormone, somatostatin and glucagon in hepatic resection \[J\]. Hepatogastroenterology，1998; 45(19)∶178.
  10. 10. Baruch Y, Amit T, Hertz P, et al. Growth hormonebinding protein in partially hepatectomized rats \[J\]. Horm Res，1993; 40(5-6)∶173.
  11. 11. Asakawa K, Hizuka N, Takano K,et al. Human growth hormone stimulates liver regeneration in rats \[J\]. J Endocrinol Invest，1989;12(5)∶343.
  12. 12. Ekberg S, Luther M, Nakamura J, et al. Growth hormone promotes early initiation of hepatocyte growth factor gene expression in the liver of hypophysectomized rats after partial hepatectomy \[J\]. J Endocrinol，1992; 135(1)∶59.
  13. 13. Buckley AR, Crowe PD, Bauman PA, et al. Prolactinprovoked alterations of cytosolic, membrane, and nuclear protein kinase C following partial hepatectomy \[J\]. Dig Dis Sci，1991; 36(9)∶1313.
  14. 14. Francavilla A, Eagon PK, Dileo A, et al. Sex hormonerelated functions in regenerating male rat liver \[J\]. Gastroenterology，1986; 91(5)∶1263.
  15. 15. Francavilla A, Gavaler JS, Makowka L, et al. Estradiol and testosterone levels in patients undergoing partial hepatectomy. A possible signal for hepatic regeneration \[J\]. Dig Dis Sci，1989; 34(6)∶818.
  16. 16. Starzl TE, Francavilla A, Halgrimson CG, et al. The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood \[J\]. Surg Gynecol Obstet, 1973; 137(2)∶179.
  17. 17. Fujiwara K, Ogata I, Sato Y, et al. Insulin and glucagon therapy of acute hepatic failure \[J\]. Dig Dis Sci，1991; 36(6)∶809.
  18. 18. Lai HS, Chung YC, Chen WJ, et al. Rat liver regeneration after partial hepatectomy：effects of insulin, glucagon and epidermal growth factor \[J\]. J Formos Med Assoc，1992;91(7)∶685.
  19. 19. Barbason H, Bouzahzah B, Herens C, et al. Circadian synchronization of liver regeneration in adult rats： the role plaged by adrenal hormones \[J\]. Cell Tissue Kinet，1989; 22(6)∶451.
  20. 20. Krasil’nikov MA, Bogdanova NN, Adler VV. Inhibition of proliferation of normal and neoplastic liver cell under conditions of prolonged hormonal stimulation \[J\]. Biokhimiia，1989; 54(4)∶656.
  21. 21. Hatta S. Influence of plasma hormone levels on various stimulantinduced hepatic DNA synthesis in carbon tetrachorideintoxicated rats \[J\]. Jpn J Pharmacol，1985; 37(1)∶77.
  22. 22. Hasegawa K, Kar S, Carr BI. Stimulation of hepatocyte DNA synthesis by neurotensin \[J\]. J Cell Physiol，1994; 158(2)∶215.
  23. 23. Rasmussen TN, Jorgensen PE, Almdal T, et al. Effect of gastrin in liver regeneration after partial hepatectomy in rats \[J\]. Gut，1990; 31(1)∶92.
  24. 24. VanThiel DH, Stauber R, Gavaler JS, et al. Hepatic regeneration. Effects of age, sex hormone status, prolactin, and cyclosporine \[J\]. Dig Dis Sci，1991; 36(9)∶1309.
  25. 25. Kahn D, Gavaler JS, Lai H, et al. Effect of cyclosporine on hepatic cytosolic estrogen and androgen receptor levels before and after partial hepatectomy \[J\]. Dig Dis Sci，1990; 35(1)∶6.