• 四川大學(xué)華西醫(yī)院普外科（成都610041）;

目的探討膽囊膽固醇結(jié)石患者脂質(zhì)代謝變化及其在膽石成因中的地位和作用。方法檢測161例膽囊膽固醇結(jié)石患者及94例非結(jié)石病患者的血脂和載脂蛋白（apolipoprotein,Apo）。結(jié)果膽石組甘油三酯(TG)和載脂蛋白CⅡ（Apo CⅡ）及載脂蛋白CⅢ（Apo CⅢ）水平明顯高于對照組，而總膽固醇（TC）、高密度脂蛋白膽固醇（HDLc）及其亞組分和低密度脂蛋白膽固醇（LDLc）明顯低于對照組（P＜0.01或P＜0.05）； 載脂蛋白AⅡ（Apo AⅡ）、載脂蛋白B100（Apo B100）及載脂蛋白E（Apo E）比對照組升高，載脂蛋白AⅠ（Apo AⅠ）比對照組低，但差異無顯著性意義（P gt;0.05）。結(jié)論TG、Apo CⅡ及Apo CⅢ水平的升高和TC、LDLc、HDLc及其亞組分水平的降低，是膽固醇結(jié)石患者脂質(zhì)代謝的重要特征，也可能是膽石形成的重要原因。

引用本文： 姚有貴,李寧,林琦遠(yuǎn),程南生,肖路加. 膽囊膽固醇結(jié)石患者血脂和載脂蛋白水平的觀察. 中國普外基礎(chǔ)與臨床雜志, 2002, 9(3): 186-188. doi: 復(fù)制

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5. Zannis VI，Breslow JL. Genetic mutations affecting human lipoprotein metabolism [J]. Adv Hum Genet，1985; 14（1）∶125.
6. Alvaro D, Angelico F, Attili AF, et al. Plasma lipid lipoproteins and biliary lipid composition in female gallstone patients [J]. Biomed Biochem Acta，1986; 45（5）∶761.
7. Thijs C, Knipschild P, Brombacher P, et al. Serum lipids and gallstones, a casecontrol study [J]. Gastroenterology，1990; 99（6）∶843.
8. Hoeg JM, Meng MS, Ronan R, et al. Human apolipoprotein AI [J]. J Biochem，1986; 261（8）∶3911.
9. Mahley RW, Innerarity TL, Rall SC, et al. Plasma lipoproteins:apolipoprotein structure and function [J]. J Lipid Res，1984; 25（11）∶1277.
10. Kibe A, Holzbach RT, LaRusso NT, et al. Inhibition of cholesterol crytal formation by apolipoprotein AI and AII in model systems of supersaturated bile: implication a for gallstones pathogenesis in man [J]. Science，1984; 225（3）∶514.
11. Bravo E. Hepatic uptake and processing of free cholesterol from different lipoproteins with and without sodium taurocholate administration, an in vivo study in the rat [J]. Biolchem Biophys Acta，1990; 74（5）∶1045.
12. 付賢波，宮軻，邵曉明，等. 血清脂質(zhì)、載脂蛋白與膽汁類脂水平及膽囊結(jié)石類型的關(guān)系 \[J\]. 中華醫(yī)學(xué)雜志，1995;75(11)∶656.
13. Gylling H, Kontula K, Miettinen TA,et al. Cholesterol absorption and metabolism and LDL kinetics in healthy men with different apolipoprotein E phenotypes and apolipoprotein B Xba I and LDL receptor Pvu II genotypes [J]. Arterioscler Thromb Vasc Biol，1995; 15（2）∶208.
  1. 1. Mohr GC, KritzSilverstein D,BarrettConnor E. Plasma lipids and gallbladder disease [J]. Am J Epidemiol，1991; 134(1)∶78.
  2. 2. Admirand WH. The physicochemical basis of cholesterol gallstone formation in man [J]. J Clin Invest，1968; 17(5)∶1043.
  3. 3. Harvey RRC. Will the real cholesterolnucleating and antinucleating proteins please stand up [J]? Gastroenterology，1993; 104(4)∶646.
  4. 4. Breslow JL. Apolipoprotein genetic variation and human disease \[M\]. Physiol Rev，1988∶68-85.
  5. 5. Zannis VI，Breslow JL. Genetic mutations affecting human lipoprotein metabolism [J]. Adv Hum Genet，1985; 14（1）∶125.
  6. 6. Alvaro D, Angelico F, Attili AF, et al. Plasma lipid lipoproteins and biliary lipid composition in female gallstone patients [J]. Biomed Biochem Acta，1986; 45（5）∶761.
  7. 7. Thijs C, Knipschild P, Brombacher P, et al. Serum lipids and gallstones, a casecontrol study [J]. Gastroenterology，1990; 99（6）∶843.
  8. 8. Hoeg JM, Meng MS, Ronan R, et al. Human apolipoprotein AI [J]. J Biochem，1986; 261（8）∶3911.
  9. 9. Mahley RW, Innerarity TL, Rall SC, et al. Plasma lipoproteins:apolipoprotein structure and function [J]. J Lipid Res，1984; 25（11）∶1277.
  10. 10. Kibe A, Holzbach RT, LaRusso NT, et al. Inhibition of cholesterol crytal formation by apolipoprotein AI and AII in model systems of supersaturated bile: implication a for gallstones pathogenesis in man [J]. Science，1984; 225（3）∶514.
  11. 11. Bravo E. Hepatic uptake and processing of free cholesterol from different lipoproteins with and without sodium taurocholate administration, an in vivo study in the rat [J]. Biolchem Biophys Acta，1990; 74（5）∶1045.
  12. 12. 付賢波，宮軻，邵曉明，等. 血清脂質(zhì)、載脂蛋白與膽汁類脂水平及膽囊結(jié)石類型的關(guān)系 \[J\]. 中華醫(yī)學(xué)雜志，1995;75(11)∶656.
  13. 13. Gylling H, Kontula K, Miettinen TA,et al. Cholesterol absorption and metabolism and LDL kinetics in healthy men with different apolipoprotein E phenotypes and apolipoprotein B Xba I and LDL receptor Pvu II genotypes [J]. Arterioscler Thromb Vasc Biol，1995; 15（2）∶208.