• 1.吉林大學第一醫(yī)院普通外科（長春130021）;;
  • 2.內(nèi)蒙古民族大學附屬醫(yī)院（通遼028000）;;
  • 3.吉林大學第二醫(yī)院（長春130021）;

目的研究抑凋亡基因bcl2和促凋亡基因bax在大腸癌及癌旁組織中的表達及意義。方法應用免疫組織化學SP法對31例大腸癌患者的癌組織及距癌組織外緣3 cm內(nèi)的癌旁組織和3 cm以遠的正常大腸組織中bcl2和bax基因的表達進行檢測。結(jié)果大腸癌及其癌旁組織中bcl2蛋白表達陽性率分別為64.5%和60.0%，顯著高于正常組織（35.0%），P＜0.05； bax蛋白表達陽性率分別為45.2%和45.0%，顯著低于正常組織（60.0%），P＜0.05； 大腸癌組織與癌旁組織中bcl2和bax蛋白表達陽性率的差異無顯著性意義（P gt;0.05）。bcl2和bax蛋白在大腸癌組織中的表達與其病理類型和臨床分期無明顯關系（P gt;0.05）。結(jié)論大腸癌及其癌旁組織中有不同水平的bcl2蛋白過度表達和bax蛋白低表達，兩者通過參與調(diào)節(jié)細胞凋亡而與大腸癌的發(fā)生有關，但與大腸癌的病理類型、臨床分期無關。距大腸癌組織外緣3 cm以內(nèi)的癌旁組織應視為癌前期組織，手術時應切除。

引用本文： 王舉,竇忠霞,韓喜春,程雷,黃大鶴. 大腸癌及癌旁組織中抑凋亡基因bcl2和促凋亡基因bax的表達及意義. 中國普外基礎與臨床雜志, 2002, 9(4): 252-254. doi: 復制

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