• 1.大連醫(yī)科大學(xué)附屬四院普外科(大連116001）;;
  • 2.白求恩醫(yī)科大學(xué)附屬三院基本外科（長春130021）;;
  • 3.大連醫(yī)科大學(xué)附屬二院（大連116023）;

目的探討c-met及p53表達(dá)在乳腺癌血管生成中的作用及其臨床意義。方法應(yīng)用SP免疫組化方法和計(jì)算機(jī)圖像分析技術(shù)，對80例乳腺癌、20例乳腺纖維腺瘤的微血管計(jì)數(shù)（MVC）和c-met及p53蛋白的表達(dá)進(jìn)行定量測定。結(jié)果乳腺癌組織中MVC和cmet及p53的陽性表達(dá)與乳腺癌的組織學(xué)分級(jí)、腋窩淋巴結(jié)轉(zhuǎn)移及腫瘤分期有關(guān) (P＜0.01)。MVC在c-met及p53表達(dá)陽性者明顯高于c-met及p53表達(dá)陰性者，兩者間差異有顯著性意義 (P＜0.01)。結(jié)論cmet及p53共同參與調(diào)控乳腺癌的腫瘤血管生成。

引用本文： 尹家俊,宋燕,王曉波,曲文志,孟慶成. 乳腺癌中c-met及p53表達(dá)與血管生成的關(guān)系. 中國普外基礎(chǔ)與臨床雜志, 2002, 9(5): 316-318. doi: 復(fù)制

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