目的探討血管生成與原發(fā)性膽囊癌臨床病理特征和預后的關系。方法對42例原發(fā)性膽囊癌手術切除的腫瘤標本行免疫組織化學染色（SABC法），觀察腫瘤內(nèi)微血管計數(shù)（MVC）和血管內(nèi)皮生長因子（VEGF）的表達。結(jié)果膽囊組織中MVC平均值為（70.4±20.7）個，VEGF表達陽性率為69.0%。MVC在細胞學分級為Ⅰ、Ⅱ級組中平均值為（57.9±15.4）個，在Ⅲ、Ⅳ級組中平均值為（88.8±11.5）個，兩組相比較差異有顯著性意義（P＜0.001）； 在Nevin Ⅰ、Ⅱ、Ⅲ期病例組MVC平均值為（45.0±17.0）個，Ⅳ、Ⅴ期組平均值為（77.2±16.0）個，兩組相比較差異有顯著性意義（P＜0.001）。VEGF表達陽性率與腫瘤細胞分級及腫瘤分期呈等級相關，分化差、分期晚者VEGF表達顯著增高。VEGF的表達與MVC值呈顯著正相關，MVC值高者或VEGF表達陽性者，3年生存率明顯降低。結(jié)論膽囊癌中VEGF的分泌增多可導致微血管數(shù)目增加，促進了病變進展和轉(zhuǎn)移。血管生成可作為判斷膽囊癌預后的一項有效指標。
引用本文： 楊毅軍,劉建民,石景森. 原發(fā)性膽囊癌組織中血管生成活性檢測的臨床意義. 中國普外基礎與臨床雜志, 2002, 9(5): 345-347. doi: 復制
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