• 第三軍醫(yī)大學(xué)大坪醫(yī)院野戰(zhàn)外科研究所普通外科(重慶 400042);

目的  研究大腸癌組織中胃泌素與癌基因c-myc、c-fos表達(dá)的關(guān)系，以探討胃泌素對(duì)大腸癌的促增殖作用機(jī)理。
方法 采用免疫組化SP法檢測(cè)48例大腸癌患者癌組織及癌旁粘膜胃泌素和癌基因c-myc、c-fos的表達(dá)。
結(jié)果  大腸癌組織胃泌素陽(yáng)性率為39.58%，高分化腺癌明顯高于低分化和粘液腺癌(P＜0.05)。癌組織的c.myc和c.fos表達(dá)陽(yáng)性率顯著高于癌旁粘膜和正常粘膜。胃泌素陽(yáng)性組癌組織c.myc和c.fos表達(dá)陽(yáng)性率分別為78.94%和73.68%，胃泌素陰性組分別為37.93%和31.04%，差異均有顯著性意義(P＜0.05，P＜0.01)。
結(jié)論  部分大腸癌細(xì)胞通過(guò)自分泌方式產(chǎn)生胃泌素，可能通過(guò)增加c-myc、c-fos等癌基因的表達(dá)，從而刺激癌細(xì)胞的增殖。

引用本文： 何渝軍,何雙梧,付濤. 大腸癌組織胃泌素與c-myc、c-fos表達(dá)的關(guān)系. 中國(guó)普外基礎(chǔ)與臨床雜志, 2001, 8(1): 15-17. doi: 復(fù)制

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  2. 2. 周廷沖，馬賢凱，唐佩眩等.多肽生長(zhǎng)因子基礎(chǔ)與臨床 [M].第1版.北京：中國(guó)科學(xué)技術(shù)出版社，1992∶17～25.
  3. 3. Finley GG, Koski RA, Melhem MF, et al. Expression of the gastrin gene in the normal human colon and colorectal adenocarcinoma [J]. Cancer Res, 1993; 53(12)∶2919.
  4. 4. Singh P, Owlia A, Varro A, et al. Gastrin gene expression is required for proliferation and tumorigenicity of human colon cancer cells [J]. Cancer Res, 1996; 56(18)∶4111.
  5. 5. Williams GT, Smith CA. Molecular regulation of apotosis:genetic controls on cell death [J]. Cell, 1993; 74(5)∶777.
  6. 6. Chin R, Boyle WY, Meek J, et al. The cfos protein interacts with cjun/Ap1 to stimulate transcription of ABL responsive genes [J]. Cell, 1988; 54(4)∶541.
  7. 7. Kazuyoshi Y, Toshio S, Masaru T, et al. Establishment and characterization of human signet ring cell gastric carcinoma cell lines with amplification of the cmyc oncogene [J]. Cancer Res, 1991; 51(1)∶381.
  8. 8. Wang JY, Wang H, Johnson LR. Gastrin stimulates expression of protooncogene cmyc throuth a process involving ployanines in IEC6 cells [J]， Am J Physiol. 1995; 269(cell physiol.38)∶c1474.
  9. 9. Andrea T, Yoshiaki T, Catherine S, et al. Gastrin and glycineextended progastrin processing intermediates induce different programs of early gene activation [J].J Biol Chem,1995; 270(47)∶28337.