目的 探討一氧化氮(nitric oxide,NO)對(duì)實(shí)驗(yàn)性急性膽道感染大鼠腎功能的影響作用。
方法 Wistar大鼠35只,隨機(jī)分為急性膽道感染組(AC組)、急性膽道感染加左旋精氨酸組(L組)、左旋硝基精氨酸甲基酯組(N組)、單純膽道梗阻對(duì)照組(O組)和假手術(shù)組(SO組)5組,分別測(cè)定血漿NO、BUN、Cr值和腎組織一氧化氮合成酶(NOS)活性,并行肝、腎組織病理變化觀察。
結(jié)果 L組NO、NOS高于其余各組(P<0.05),BUN、Cr低于AC組和N組(P<0.05),而與O組比較差異無(wú)顯著性意義(P>0.05),腎組織病理變化較AC組輕; N組NO、NOS低于其余各組,而B(niǎo)UN、Cr則高于其余各組(P<0.05)。
結(jié)論 NO對(duì)急性膽道感染72小時(shí)大鼠的腎功能有保護(hù)作用,其作用機(jī)理可能與其舒張腎血管,增加血液灌流量等作用有關(guān)。
引用本文: 李智宇,張炳彥,王炳煌,郭永章,張捷. 一氧化氮對(duì)急性膽道感染大鼠腎功能影響作用研究. 中國(guó)普外基礎(chǔ)與臨床雜志, 2001, 8(2): 69-71. doi: 復(fù)制
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10. | Fierro IM, NascimentoDaSilva V, Arruda MA, et al. Induction of NOS in rat blood PMN in vivo and in vitro: modulation by tyrosine kinase and involvement in bactericidal activity [J]. J Leukoc Biol, 1999; 65(4)∶508. |
- 1. 朱錫光,韓本立.一氧化氮在大鼠急性膽道感染后肝損傷中的作用及其機(jī)理研究 [J].第三軍醫(yī)大學(xué)學(xué)報(bào),1997; 19(4)∶732.
- 2. Knowles RG, Merrett M, Salter M, et al. Differential induction of brain, liver and lung nitric oxide synthase by endotoxin in the rat [J]. Biochem J, 1990; 270(3)∶833.
- 3. 韓本立,龔建平,羅丁.大鼠急性膽道感染動(dòng)物模型的建立 [J].中華實(shí)驗(yàn)外科雜志,1992; 9(1)∶10.
- 4. Moncade S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology [J]. Pharmacol Rev, 1991; 43(2)∶109.
- 5. Inan M, Sayek I, Tel BC, et al. Role of endotoxin and nitric oxide in the pathogenesis of renal failure in obstructive jaundice [J]. Br J Surg, 1997; 84(7)∶943.
- 6. Haddad IY, Pataki G, Hu P, et al. Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury [J]. J Clin Chest, 1994; 94(6)∶2407.
- 7. 王根生,劉耕陶.一氧化氮與肝細(xì)胞損傷 [J].中華醫(yī)學(xué)雜志,1995;75(1)∶57.
- 8. Endlich K, Muller C, Barthelmebs M, et al. Role of shear stress in nitric oxidedependent modulation of renal angiotensin II vasoconstriction [J]. Br J Pharmacol, 1999; 127(8)∶1929.
- 9. Olszanecki R, Chlopicki S. Endotoxaemia in rats: role of NO, PAF and TXA2 in pulmonary neutrophil sequestration and hyperlactataemia [J]. J Physiol Pharmacol, 1999; 50(3)∶443.
- 10. Fierro IM, NascimentoDaSilva V, Arruda MA, et al. Induction of NOS in rat blood PMN in vivo and in vitro: modulation by tyrosine kinase and involvement in bactericidal activity [J]. J Leukoc Biol, 1999; 65(4)∶508.