白濤 1 , 郭仁宣 1 , 王浩 2
  • 1.中國(guó)醫(yī)科大學(xué)附屬第一院普外科(沈陽(yáng) 110001);;
  • 2. 沈陽(yáng)華泰醫(yī)院外科(沈 陽(yáng)110031);

目的  探討腫瘤微血管密度(MVD)與膽囊癌的侵襲轉(zhuǎn)移和預(yù)后的關(guān)系。
方法  應(yīng)用免疫組化法，用抗人因子Ⅷ相關(guān)抗原(FⅧRAg)的單克隆抗體測(cè)定42例人膽囊癌組織中的MVD，并分析其與膽囊癌各種病理因素及預(yù)后之間的關(guān)系。
結(jié)果  MVD與膽囊癌浸潤(rùn)深度(P＜0.05)、淋巴結(jié)轉(zhuǎn)移(P＜0.01)和遠(yuǎn)處轉(zhuǎn)移(P＜0.05)密切相關(guān)，而與病理類型、分化程度無(wú)關(guān)(P＞0.05)； MVD＞54.82的膽囊癌患者5年生存率較低。
結(jié)論  腫瘤微血管密度與膽囊癌浸潤(rùn)深度、淋巴結(jié)及遠(yuǎn)處轉(zhuǎn)移密切相關(guān)，對(duì)判斷膽囊癌的預(yù)后具有重要的臨床意義。

引用本文： 白濤,郭仁宣,王浩. 血管生成與膽囊癌發(fā)展和預(yù)后的關(guān)系. 中國(guó)普外基礎(chǔ)與臨床雜志, 2001, 8(2): 101-103. doi: 復(fù)制

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  1. 1. Folkman J. Tumor angiogenesis:therapeutic implications [J]. N Engl J Med, 1971; 285∶1182.
  2. 2. Moscatelli D, Gross J, Rifkin D. Angiogenesis factors stimulate plasminogen activator and collagenase production by capillary endothelial cells [J]. J Cell Biol, 1981; 91∶201.
  3. 3. Toi M, Kashitani J, Tominaga T. Tumor angiogenesis is an indepent prognostic indicator in primary breast carcinoma [J]. Int J Cancer, 1993; 55∶371.
  4. 4. Weidner N, Carroll PR, Flax J. Tumor Angiogenesis Correlates with Metastasis in Invasive Prostate Carcinoma [J]. Am J Pathol, 1993; 143∶401.
  5. 5. Macchiarini P, Fontanini G, Hardin MJ, et al. Relation of neovascularisation to metastasis of nonsmallcell lung cancer [J]. Lancet, 1992; 340∶145.
  6. 6. Weidner N. Current Pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors [J]. Breast Cancer Res Treat, 1995; 36∶169.
  7. 7. Jianxin Wu. Apoptosis and angiogenesis: two promising tumor markers in breast cancer [J]. Anticancer Res, 1996; 16∶2233.