• 1.西安交通大學(xué)第一醫(yī)院普通外科(西安 710061);;
  • 2.日本鹿兒島大學(xué)醫(yī)學(xué)院第一外科;

目的  研究早期胃癌MiB-1表達與臨床病理的關(guān)系。
方法  采用免疫組織化學(xué)法，對99例早期胃癌手術(shù)切除標(biāo)本進行檢測。
結(jié)果  MiB-1增殖指數(shù)(MiB-1 PI)與患者年齡、腫瘤大小、部位及浸潤深度有關(guān)。分化型腺癌MiB-1 PI高于低分化腺癌(P＜0.01)； 胃壁淋巴管浸潤或淋巴結(jié)轉(zhuǎn)移陽性腫瘤的MiB-1 PI較高(P＜0.05)。MiB-1增殖等級(MiB-1 PG)與患者術(shù)后生存率有關(guān)，MiB-1 PGⅠ、Ⅱ級術(shù)后生存高于MiB-1 PG Ⅲ、Ⅳ級(P＜0.05)。
結(jié)論  即使在胃癌早期，腫瘤的不同增殖水平亦與患者的預(yù)后直接相關(guān)。

引用本文： 車向明,王康,帆北修一,愛甲孝. MiB-1的表達與早期胃癌臨床病理及預(yù)后的關(guān)系. 中國普外基礎(chǔ)與臨床雜志, 2001, 8(3): 145-147. doi: 復(fù)制

1. Key G, Becher MHG, Duchrow M, et al. New Ki67 equivalent murine monoclonal antibodies (MiB1) prepared against recombinant parts of the Ki67 antigen 〔J〕. Anal Cell Pathol, 1992； 4(2)∶181.
2. Moul JW, Bettencourt MC, Sesterhern IA, et al. Protein expression of p53, bcl2 and Ki67 (MiB1) as prognostic biomarkers in patients with surgically treated, clinically localized prostate cancer 〔J〕. Surgery, 1996； 120(2)∶159.
3. Lam KY, Law SY, So MK, et al. Prognostic implication of proliferative markers MiB1 and PC10 in esophageal squamous cell carcinoma 〔J〕. Cancer, 1996； 77(1)∶7.
4. Japanese research society for gastric cancer. The general rules for the gastric study 〔C〕. 12th endition. Tokyo. Kanehara & CO, LTD.1993∶1-53.
5. Muller W, Schneiders A, Meier S, et al. Immunohistochemical study on the prognosis value of MiB 1 in gastric carcinoma 〔J〕. Br J Cancer, 1996； 74(5)∶759.
6. Frank RE, Saclarides TJ, Leurgans S, et al. Tumor angiogenesis as a predicator of recurrence and survival in patients with nodenegative colon cancer 〔J〕. Anal Surg, 1995； 222(6)∶695.
7. Kimura H, Yonemura Y, Epstein AL. Flowcytometric quantitation of the proliferation associated nuclear antigen p105 and DNA content in advanced gastric cancer 〔J〕. Cancer, 1991； 68(12)∶2175.
8. Saitoh K, Chiba T, Nakamura K. Cell proliferation kinetics of human gastric carcinoma:an immunohistochemical study with a monoclonal antibody against DNA polymeraseα 〔J〕. Euro J Cancer, 1992； 28（10）∶1642.
9. 車向明，帆北修一，愛甲孝.70歲以上老年人早期胃癌的臨床病理特點 〔J〕.中國普通外科雜志，1997； 6(3)∶129.
10. 車向明，帆北修一，愛甲孝.早期胃癌的臨床病理特點 〔J〕.西安醫(yī)科大學(xué)學(xué)報,1997； 8(2)∶15.
11. Kidama Y, Inoduchi K, Spejima K, et al. Growth patterns and prognosis in early gastric carcinoma superficially spreading and penetrating growth types 〔J〕. Cancer , 1983； 52(2)∶320.
  1. 1. Key G, Becher MHG, Duchrow M, et al. New Ki67 equivalent murine monoclonal antibodies (MiB1) prepared against recombinant parts of the Ki67 antigen 〔J〕. Anal Cell Pathol, 1992； 4(2)∶181.
  2. 2. Moul JW, Bettencourt MC, Sesterhern IA, et al. Protein expression of p53, bcl2 and Ki67 (MiB1) as prognostic biomarkers in patients with surgically treated, clinically localized prostate cancer 〔J〕. Surgery, 1996； 120(2)∶159.
  3. 3. Lam KY, Law SY, So MK, et al. Prognostic implication of proliferative markers MiB1 and PC10 in esophageal squamous cell carcinoma 〔J〕. Cancer, 1996； 77(1)∶7.
  4. 4. Japanese research society for gastric cancer. The general rules for the gastric study 〔C〕. 12th endition. Tokyo. Kanehara & CO, LTD.1993∶1-53.
  5. 5. Muller W, Schneiders A, Meier S, et al. Immunohistochemical study on the prognosis value of MiB 1 in gastric carcinoma 〔J〕. Br J Cancer, 1996； 74(5)∶759.
  6. 6. Frank RE, Saclarides TJ, Leurgans S, et al. Tumor angiogenesis as a predicator of recurrence and survival in patients with nodenegative colon cancer 〔J〕. Anal Surg, 1995； 222(6)∶695.
  7. 7. Kimura H, Yonemura Y, Epstein AL. Flowcytometric quantitation of the proliferation associated nuclear antigen p105 and DNA content in advanced gastric cancer 〔J〕. Cancer, 1991； 68(12)∶2175.
  8. 8. Saitoh K, Chiba T, Nakamura K. Cell proliferation kinetics of human gastric carcinoma:an immunohistochemical study with a monoclonal antibody against DNA polymeraseα 〔J〕. Euro J Cancer, 1992； 28（10）∶1642.
  9. 9. 車向明，帆北修一，愛甲孝.70歲以上老年人早期胃癌的臨床病理特點 〔J〕.中國普通外科雜志，1997； 6(3)∶129.
  10. 10. 車向明，帆北修一，愛甲孝.早期胃癌的臨床病理特點 〔J〕.西安醫(yī)科大學(xué)學(xué)報,1997； 8(2)∶15.
  11. 11. Kidama Y, Inoduchi K, Spejima K, et al. Growth patterns and prognosis in early gastric carcinoma superficially spreading and penetrating growth types 〔J〕. Cancer , 1983； 52(2)∶320.