• 1.江蘇省無錫市第二人民醫(yī)院(無錫214002);;
  • 2.上海第二醫(yī)科大學瑞金醫(yī)院普外科(上海200025);

目的  探討cyclin D1、cyclin E和p27蛋白在胃癌中的表達及其意義。
方法 用免疫組化法檢測60例胃癌組織中cyclin D1、cyclin E和p27蛋白的表達。
結(jié)果  胃癌組織中cyclin D1、cyclin E和p27蛋白表達陽性率分別為41.7%（25/60）、38.3%（23/60）和36.7%（22/60）； cyclin D1在胃癌中的表達與腫瘤Lauren分型相關(guān)，cyclin E在胃癌中的表達與腫瘤分化程度、浸潤深度及腫瘤分期相關(guān)，而p27蛋白的表達與腫瘤浸潤深度、淋巴結(jié)轉(zhuǎn)移和腫瘤分期相關(guān)。另外，cyclin E和p27蛋白在胃癌中的表達呈顯著負相關(guān)。
結(jié)論  檢測胃癌組織中cyclin D1、cyclin E和p27蛋白的表達有助于判斷腫瘤的進展程度。

引用本文： 夏加增,楊繼昌,張熔熔,朱正綱,尹浩然. 胃癌中cyclin D1、cyclin E和p27的表達及其意義. 中國普外基礎與臨床雜志, 2001, 8(3): 148-150. doi: 復制

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  1. 1. Lazzereschi D,Sanbuco L,Scalzo CC,et al.Cyclin D1 and cyclin E expression in malignant thyroid cells and in human thyroid carcinomas 〔J〕. Int J Cancer,1998； 76(6)∶806.
  2. 2. Muller W,Noguchi T,Wirtz HC,et al.Expression of cellcycle regulatory proteins cyclin D1,cyclin E,and their inhibitor p21 waf 1/cip 1 in gastric cancer 〔J〕. J Pathol,1999； 189(1)∶186.
  3. 3. Kim SJ,Lee JB,Kim CS,et al.Cyclin D1 and p21 expression in gastric adenocarcinoma 〔C〕.3rd. International Gastric Cancer Congress, 1999∶359~360.
  4. 4. Yasui W,Akama Y,Kuniyasu H,et al.Expression of cyclin E in human gastric adenomas and adenocarcinomas: correlation with proliferative activity and p53 status 〔J〕. J Exp Ther Oncol,1996； 1(1)∶88.
  5. 5. Yasui W,Kudo Y,Semba S,et al.Reduced expression of cyclindependent kinase inhibitor p27 kip1 is associated with advanced stage and invasiveness of gastric carcinomas 〔J〕.Jpn J Cancer Res,1997； 88(7)∶625.
  6. 6. Fredersdorf S,Burns J,Milne AM,et al.High level expression of p27 kip1 and cyclin D1 in some human breast cancer cells:inverse correlation between the expression of p27 kip1 and degree of malignancy in human breast and colorectal cancers 〔J〕.Proc Natl Acad Sci USA,1997； 94(12)∶6380.