• 天津市第一中心醫(yī)院移植外科（天津300192）;

目的  了解枯否細(xì)胞在肝臟缺血再灌注損傷中的作用。
方法  采用文獻(xiàn)回顧的方法對枯否細(xì)胞在肝臟缺血再灌注損傷中的作用加以綜述。
結(jié)果  活化后的枯否細(xì)胞可產(chǎn)生和釋放多種介質(zhì)直接或間接地影響肝臟微循環(huán)。
結(jié)論  枯否細(xì)胞在肝缺血再灌注損傷中發(fā)揮了重要作用。

引用本文： 常文建,綜述 陸貫一,審校. 枯否細(xì)胞和肝臟缺血再灌注損傷. 中國普外基礎(chǔ)與臨床雜志, 2001, 8(4): 276-278. doi: 復(fù)制

1. Sankary HN, Chong A, Coleman JA, et al. Inactivation of kupffer cells after prolonged donor fasting improves viability of transplanted hepaticallografts 〔Ｊ〕. Hepotology, 1995; 22(3)∶1242.
2. Ishikawa T, Yagi T, Sakamoto M, et al. Kupffer cell activiation in survival discrepancy between liver grafts from emterally and parenterally fed donors 〔Ｊ〕. Transpl Int, 1998；11(Suppl 1)∶410.
3. Uchida M, Takemoto M, Yamamoto M, et al. Calcium in pig livers following ischemia and reperfusion 〔Ｊ〕. Hepaol, 1994； 20∶714.
4. Schultze RL, Gangopadhyay A, He BF, et al. Tyrosine kinase activiation in LPS stimulated rat kupffer cells 〔Ｊ〕. Cell Biochem Biophys, 1999; 30(2)∶287.
5. 盧綺萍， 史陳讓， 陳孝平等. 影響肝缺血再灌注損傷主導(dǎo)因素的機(jī)理 〔Ｊ〕. 中華實(shí)驗(yàn)外科雜志， 1996； 13（6）∶369.
6. 盧綺萍， 史陳讓， 吳在德等. 丹參防治肝缺血再灌注期肝細(xì)胞內(nèi)鈣超載的實(shí)驗(yàn)與臨床研究 〔Ｊ〕. 中華外科雜志， 1996； 34（2）∶98.
7. Zhong Z, Connor H, Mason RP, et al. Destruction of kupffer cells increases survival and reduces graft injury after transplantation of fatty livers from ethanol treated rats 〔Ｊ〕. Liver Transpl Surg, 1996; 2(5)∶383.
8. Jaeschke H, Smith CV, Hughes H, et al. The isolated perfusedrat liver conceptual and practical considerration 〔Ｊ〕. Hepatology, 1998; 8∶1250.
9. Clavien PA, Harrey PR, Marzi S, et al. Preservation and reperfusion injuries in liver allografts 〔Ｊ〕. Transplantation, 1992; 53(5)∶957.
10. Marzi, Knee J, Bvhren V, et al. Reduction by superoxide dismutase of leukocyteendothelial adherence after liver transplantation 〔Ｊ〕. Surgery, 1992; 11(1)∶90.
11. Loft S, Larsen PN, Whittle B, et al. Oxidative DNA damage after transplantation of liver and small intestine in pigs 〔Ｊ〕. Transplantation, 1995; 59(1)∶16.
12. Hamlolin AS, Smith CV, Shunder RA, et al. Renal hemodynamics, urinary eicosanmoids and endothelin after livtransplantartion 〔Ｊ〕. Immunol, 1998; (suppl 1)∶39.
13. Vlcek, Takada YN, Jacck B, et al. Endothelin releasea facet of reperfusion injury in clinical liver transplantation 〔Ｊ〕. Chem, 1991; 266∶7313.
14. Goto M, Takei, Kawano S, et al. Tumor necrosis factor and endotoxin in the pathogenesis of liver and pulmonary injury after orthrotopic liver transplantation in the rat 〔Ｊ〕. Hepatology, 1992; 16∶487.
15. Arii S, Imamura M, Seger R, et al. Liver transplantation and hepatic sinusodial cells 〔Ｊ〕. J Gastroenteral Hepatol, 1995; 10(Suppl 1)∶92.
16. Braquet P, Koltai M, Bourgain R. Is there a care for PAF antagonists in the treatment of ischemic states 〔Ｊ〕. TIPS, 1989; 10(1)∶23.
17. Serizawa A, Nakamura S, Lerman L, et al. Involvement of platelet activating factor in cytokine production and neutrophil activation after hepatic ischemia reperfusion 〔Ｊ〕. Hepatology, 1996; 23(6)∶1656.
18. 呂建中，史留斌，陳懷仁等. 血小板激活因子及其拮抗劑在肝臟缺血再灌注損傷中的作用 〔Ｊ〕. 中華實(shí)驗(yàn)外科雜志， 1997； 4（3）∶169.
19. Takei Y, Marzi I, Saker J, et al. Survival time of liver transplantation by protease inhibitors and a calcium channel blocker, nisoldipine 〔Ｊ〕. Transplantation, 1997; 2∶569.
20. Schemmer P, Mehra L, Rouse L, et al. Gentle in situ liver manipulation during organ harvest decreases survival after rat liver transplantation: role of kupffer cells 〔Ｊ〕. Transplantation, 1998; 65(8)∶1015.
21. Lemasters JJ, Buhren L, Souse V,et al. Dual role of kupffer cell activation and endothelial cell damagen reperfusion injury to livers stored for transplantation surgery 〔Ｊ〕. Gastroenterol Hapatol, 1995; 10(Suppl 1)∶84.
22. Thurman RG. Nmehra K, Suzuki S, et al. Role of kupffer cells in failure of fatty livers following liver transplantation and alcoholic liver injury 〔Ｊ〕. J Gastroenterol Hapatol, 1995; 1(Suppl 1)∶24.
  1. 1. Sankary HN, Chong A, Coleman JA, et al. Inactivation of kupffer cells after prolonged donor fasting improves viability of transplanted hepaticallografts 〔Ｊ〕. Hepotology, 1995; 22(3)∶1242.
  2. 2. Ishikawa T, Yagi T, Sakamoto M, et al. Kupffer cell activiation in survival discrepancy between liver grafts from emterally and parenterally fed donors 〔Ｊ〕. Transpl Int, 1998；11(Suppl 1)∶410.
  3. 3. Uchida M, Takemoto M, Yamamoto M, et al. Calcium in pig livers following ischemia and reperfusion 〔Ｊ〕. Hepaol, 1994； 20∶714.
  4. 4. Schultze RL, Gangopadhyay A, He BF, et al. Tyrosine kinase activiation in LPS stimulated rat kupffer cells 〔Ｊ〕. Cell Biochem Biophys, 1999; 30(2)∶287.
  5. 5. 盧綺萍， 史陳讓， 陳孝平等. 影響肝缺血再灌注損傷主導(dǎo)因素的機(jī)理 〔Ｊ〕. 中華實(shí)驗(yàn)外科雜志， 1996； 13（6）∶369.
  6. 6. 盧綺萍， 史陳讓， 吳在德等. 丹參防治肝缺血再灌注期肝細(xì)胞內(nèi)鈣超載的實(shí)驗(yàn)與臨床研究 〔Ｊ〕. 中華外科雜志， 1996； 34（2）∶98.
  7. 7. Zhong Z, Connor H, Mason RP, et al. Destruction of kupffer cells increases survival and reduces graft injury after transplantation of fatty livers from ethanol treated rats 〔Ｊ〕. Liver Transpl Surg, 1996; 2(5)∶383.
  8. 8. Jaeschke H, Smith CV, Hughes H, et al. The isolated perfusedrat liver conceptual and practical considerration 〔Ｊ〕. Hepatology, 1998; 8∶1250.
  9. 9. Clavien PA, Harrey PR, Marzi S, et al. Preservation and reperfusion injuries in liver allografts 〔Ｊ〕. Transplantation, 1992; 53(5)∶957.
  10. 10. Marzi, Knee J, Bvhren V, et al. Reduction by superoxide dismutase of leukocyteendothelial adherence after liver transplantation 〔Ｊ〕. Surgery, 1992; 11(1)∶90.
  11. 11. Loft S, Larsen PN, Whittle B, et al. Oxidative DNA damage after transplantation of liver and small intestine in pigs 〔Ｊ〕. Transplantation, 1995; 59(1)∶16.
  12. 12. Hamlolin AS, Smith CV, Shunder RA, et al. Renal hemodynamics, urinary eicosanmoids and endothelin after livtransplantartion 〔Ｊ〕. Immunol, 1998; (suppl 1)∶39.
  13. 13. Vlcek, Takada YN, Jacck B, et al. Endothelin releasea facet of reperfusion injury in clinical liver transplantation 〔Ｊ〕. Chem, 1991; 266∶7313.
  14. 14. Goto M, Takei, Kawano S, et al. Tumor necrosis factor and endotoxin in the pathogenesis of liver and pulmonary injury after orthrotopic liver transplantation in the rat 〔Ｊ〕. Hepatology, 1992; 16∶487.
  15. 15. Arii S, Imamura M, Seger R, et al. Liver transplantation and hepatic sinusodial cells 〔Ｊ〕. J Gastroenteral Hepatol, 1995; 10(Suppl 1)∶92.
  16. 16. Braquet P, Koltai M, Bourgain R. Is there a care for PAF antagonists in the treatment of ischemic states 〔Ｊ〕. TIPS, 1989; 10(1)∶23.
  17. 17. Serizawa A, Nakamura S, Lerman L, et al. Involvement of platelet activating factor in cytokine production and neutrophil activation after hepatic ischemia reperfusion 〔Ｊ〕. Hepatology, 1996; 23(6)∶1656.
  18. 18. 呂建中，史留斌，陳懷仁等. 血小板激活因子及其拮抗劑在肝臟缺血再灌注損傷中的作用 〔Ｊ〕. 中華實(shí)驗(yàn)外科雜志， 1997； 4（3）∶169.
  19. 19. Takei Y, Marzi I, Saker J, et al. Survival time of liver transplantation by protease inhibitors and a calcium channel blocker, nisoldipine 〔Ｊ〕. Transplantation, 1997; 2∶569.
  20. 20. Schemmer P, Mehra L, Rouse L, et al. Gentle in situ liver manipulation during organ harvest decreases survival after rat liver transplantation: role of kupffer cells 〔Ｊ〕. Transplantation, 1998; 65(8)∶1015.
  21. 21. Lemasters JJ, Buhren L, Souse V,et al. Dual role of kupffer cell activation and endothelial cell damagen reperfusion injury to livers stored for transplantation surgery 〔Ｊ〕. Gastroenterol Hapatol, 1995; 10(Suppl 1)∶84.
  22. 22. Thurman RG. Nmehra K, Suzuki S, et al. Role of kupffer cells in failure of fatty livers following liver transplantation and alcoholic liver injury 〔Ｊ〕. J Gastroenterol Hapatol, 1995; 1(Suppl 1)∶24.