目的 了解幾種常見甲狀腺病變組織中端粒酶活性的區(qū)別。方法 用端粒重復(fù)序列擴(kuò)增法測定19例甲狀腺癌、15例甲狀腺癌癌旁組織、21例甲狀腺腺瘤、17例結(jié)節(jié)性甲狀腺腫及13例正常甲狀腺組織端粒酶的活性。 結(jié)果 94.74%（18／19）的甲狀腺癌表達(dá)出端粒酶活性，與癌旁組織(6.67%)、甲狀腺腺瘤(4.67%)、結(jié)節(jié)性甲狀腺腫（0%）及正常甲狀腺組織（0%）比較，差異均有顯著性意義（P＜０.0001）。結(jié)論 端粒酶是甲狀腺癌定性的良好標(biāo)志物，且在甲狀腺病變的鑒別診斷中具有重要意義。
引用本文： 吳興桂,齊保慶,宋豫軍. 甲狀腺病變組織中端粒酶活性的測定及其意義. 中國普外基礎(chǔ)與臨床雜志, 2001, 8(5): 313-314. doi: 復(fù)制
| 1. | Kim NW, Piatyszek MA, Prowae KR, et al. Specific association of human telomerase activity with immortal cells and cancer 〔Ｊ〕. Science， 1994； 266(5193)∶2011. |
| 2. | Hiyama E, Hiyama K, Yokoyama T, et al. Telomerase activity in smallcell and nonsmallcell lung cancers 〔Ｊ〕. J Natl Cancer Inst， 1995； 87(12)∶895. |
| 3. | Tahara H, Nakanishi T, Kitamoto M, et al. Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinoma 〔Ｊ〕. Cancer Res， 1995； 55(13)∶2734. |
| 4. | Hiyama E, Gollahan L, Kataoka T, et al. Telomerase activity in human breast tumors 〔Ｊ〕. J Natl Cancer Inst， 1996； 88(2)∶116. |
| 5. | Langford LA, Piatyszek MA, Xu R, et al. Telomerase activity in human brain tumors 〔Ｊ〕. Lancet， 1995； 346(8985)∶1267. |
| 6. | Hiyama E, Youkyama T, Kuni N, et al. Telomerase activity in gastric cancer 〔Ｊ〕. Cancer Res， 1995； 55(15)∶3258. |
| 7. | Koyanagi K, Ozawa S, Ando N, et al. Clinical significance of telomerase activity in noncancerous epithelial region of esophageal squamous cell carcinoma 〔Ｊ〕. Br J Surg， 1999； 86(5)∶ 674. |
| 8. | Koyanagi K, Ozawa S, Ando N,et al. Telomerase activity as an indicator of malignant potential in iodinenonreactive lesions of the esophagus 〔Ｊ〕.Cancer，2000； 88(7)∶1524. |
| 9. | Hiyama E, Saeki T, Hiyama K, et al. Telomerase activity as a marker of breast carcinoma in fineneedle aspirated samples 〔Ｊ〕. Cancer， 2000； 90(4)∶ 2358. |
- 1. Kim NW, Piatyszek MA, Prowae KR, et al. Specific association of human telomerase activity with immortal cells and cancer 〔Ｊ〕. Science， 1994； 266(5193)∶2011.
- 2. Hiyama E, Hiyama K, Yokoyama T, et al. Telomerase activity in smallcell and nonsmallcell lung cancers 〔Ｊ〕. J Natl Cancer Inst， 1995； 87(12)∶895.
- 3. Tahara H, Nakanishi T, Kitamoto M, et al. Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinoma 〔Ｊ〕. Cancer Res， 1995； 55(13)∶2734.
- 4. Hiyama E, Gollahan L, Kataoka T, et al. Telomerase activity in human breast tumors 〔Ｊ〕. J Natl Cancer Inst， 1996； 88(2)∶116.
- 5. Langford LA, Piatyszek MA, Xu R, et al. Telomerase activity in human brain tumors 〔Ｊ〕. Lancet， 1995； 346(8985)∶1267.
- 6. Hiyama E, Youkyama T, Kuni N, et al. Telomerase activity in gastric cancer 〔Ｊ〕. Cancer Res， 1995； 55(15)∶3258.
- 7. Koyanagi K, Ozawa S, Ando N, et al. Clinical significance of telomerase activity in noncancerous epithelial region of esophageal squamous cell carcinoma 〔Ｊ〕. Br J Surg， 1999； 86(5)∶ 674.
- 8. Koyanagi K, Ozawa S, Ando N,et al. Telomerase activity as an indicator of malignant potential in iodinenonreactive lesions of the esophagus 〔Ｊ〕.Cancer，2000； 88(7)∶1524.
- 9. Hiyama E, Saeki T, Hiyama K, et al. Telomerase activity as a marker of breast carcinoma in fineneedle aspirated samples 〔Ｊ〕. Cancer， 2000； 90(4)∶ 2358.