目的 探討粘附分子CD44v6和E-cadherin表達與甲狀腺乳頭狀癌（PTC）侵襲轉(zhuǎn)移的關(guān)系。 方法 應用S-P免疫組織化學方法檢測58例甲狀腺乳頭狀癌組織中CD44v6和E-cadherin的表達。 結(jié)果 甲狀腺乳頭狀癌組織中CD44v6和E-cadherin 表達陽性率分別為72.4%和41.4%； CD44v6表達陽性率與PTC 的侵襲和轉(zhuǎn)移呈正相關(guān)（P＜0.05），而E-cadherin表達陽性率與PTC的侵襲和轉(zhuǎn)移呈負相關(guān)（P＜0.01），且兩種粘附分子在PTC中的陽性表達呈負相關(guān)性（P＜0.05）。結(jié)論 粘附分子表達與PTC侵襲和轉(zhuǎn)移密切相關(guān)， 檢測CD44v6和Ecadherin 的表達可作為判斷甲狀腺乳頭狀癌預后的參考指標。
引用本文： 李子奈,邱建龍,吳春林,李良毅. 粘附分子CD44v6和Ecadherin的表達與甲狀腺乳頭狀癌侵襲轉(zhuǎn)移的關(guān)系. 中國普外基礎(chǔ)與臨床雜志, 2001, 8(5): 317-318. doi: 復制
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- 1. Ermak G,Jennings T,Robinson L,et al.Restricted pattern of CD44 variant exon expression in human papillary thyroid carcinoma 〔Ｊ〕. Cancer Res,1996; 56(5)∶1037.
- 2. Souka T,Salmi M,Joensun H, et al. Regulation of CD44v6 containing isoforms during proliferation of normal and malignant epithelial cells 〔Ｊ〕. Cancer Res,1997; 57(11)∶2281.
- 3. Gu J,Daa T,Kashima K,et al.Expression of splice variant of CD44 in thyroid neoplasms derived from follicular cells 〔Ｊ〕. Pathol Int,1998; 48(3)∶184.
- 4. Shiozaki H,Oka H, Inoue M, et al. Ecadherin mediated adhesion system in cancer cell 〔Ｊ〕. Cancer,1996; 77(9)∶1605.
- 5. 姚靈，周信達．上皮型鈣粘蛋白（Ecadherin）在癌侵襲轉(zhuǎn)移中的作用 〔Ｊ〕．中國腫瘤臨床，1997; 24(11)∶863.