• 重慶醫(yī)科大學(xué)臨床學(xué)院器官移植研究室(重慶400016);

目的  探索供體血輸入同種大鼠對誘導(dǎo)胰腺移植耐受的可能性。方法  用雄性Wistar大鼠作為實驗的供受體，胰腺移植當(dāng)天取供體大鼠全血1 ml，注入糖尿病受體大鼠腹腔，輔以短期的硫唑嘌呤(Aza)。 結(jié)果  移植胰腺功能存活時間為28～112天(平均64.2天)，與單純用硫唑嘌呤組(10.2天)或單純輸入供體血液組(9.8天)相比，移植胰腺功能存活時間顯著延長(P＜0.01)。
結(jié)論  移植前短期使用免疫抑制劑以及移植當(dāng)天輸入供體血液，能延長大鼠移植胰腺功能存活時間。

引用本文： 孫治君,姚榛祥. 輸入供體血對延長大鼠移植胰腺功能存活的初步研究. 中國普外基礎(chǔ)與臨床雜志, 2001, 8(6): 364-366. doi: 復(fù)制

1. Bushell A, Morris PJ, Wood KJ. Induction of operational tolerance by random blood transfusion combined with antiCD4 antibody therapy 〔Ｊ〕. Transplantation, 1994; 58(2)∶ 133.
2. Vogt P, Hiller WFA, Steiniger B, et al. Differential response of kidney and pancreas rejection to cyclosporine immunosuppression 〔Ｊ〕. Transplantation, 1992; 53(6)∶ 1269.
3. Klempnauer J, Vogt P, Hiller WFA. Donorspecific tolerance induced by nonmajor histocompatibility complex disparate kidney grafts for subsequent pancreas transplants 〔Ｊ〕. Transplant Pro, 1993; 25(1)∶373.
4. Tchervenkdv JI, Cofer BR, Davies C, et al. Indefinite allograft survival induced by the combination of multiple donorspecific transfusions, cyclosporine, and an antiT cell monoclonal antibody in a protocol relevant to cadaveric organ transplantation 〔Ｊ〕. Transplantation, 1995; 59(6)∶821.
5. Takiff H, Novak M, Iwaki Y, et al. Lowdose cyclosporine maintenance therapy after immunosupressive induction in a rat cardiac transplant model 〔Ｊ〕. Transplantation, 1988; 45(2)∶297.
6. 畢愛華.免疫應(yīng)答(二)免疫耐受.見: 畢愛華主編.醫(yī)學(xué)免疫學(xué) 〔M〕. 第1版. 北京: 人民軍醫(yī)出版社, 1995∶123~129.
7. Bayle F, Masson D, Zaoul P, et al. Beneficial effect of one HLA haplo or semiidentical transfusion versus three untyped blood units on alloimmunization and acute rejection episodes in first renal allograft recipients 〔Ｊ〕. Transplantation, 1995; 59(5)∶719.
8. Flye MW, Burton K, Mohanakumar T, et al. Donorspecific transfusions have longterm beneficial effects for human renal allografts 〔Ｊ〕. Transplantation, 1995; 60(12)∶1395.
9. Van Twuvver E, Mooijaart RJD, Ten Berge IJM, et al. Pretransplantation blood transfusion revisited 〔Ｊ〕. N Eng J Med, 1991; 325(17)∶1210.
10. Brunson M, Tchervenkov JI, Alexander JW, et al. Enhancement of allograft survival by donorspecific transfusion one day prior to transplant 〔Ｊ〕. Transplantation, 1991; 52(4)∶ 543.
11. Levy AE, Alexander JW. Administration of intragraft interleukin4 prolongs cardiac allograft survival in rats treated with donorspecific transfusion/cyclosporine 〔Ｊ〕. Transplantation, 1995; 60(5)∶405.
  1. 1. Bushell A, Morris PJ, Wood KJ. Induction of operational tolerance by random blood transfusion combined with antiCD4 antibody therapy 〔Ｊ〕. Transplantation, 1994; 58(2)∶ 133.
  2. 2. Vogt P, Hiller WFA, Steiniger B, et al. Differential response of kidney and pancreas rejection to cyclosporine immunosuppression 〔Ｊ〕. Transplantation, 1992; 53(6)∶ 1269.
  3. 3. Klempnauer J, Vogt P, Hiller WFA. Donorspecific tolerance induced by nonmajor histocompatibility complex disparate kidney grafts for subsequent pancreas transplants 〔Ｊ〕. Transplant Pro, 1993; 25(1)∶373.
  4. 4. Tchervenkdv JI, Cofer BR, Davies C, et al. Indefinite allograft survival induced by the combination of multiple donorspecific transfusions, cyclosporine, and an antiT cell monoclonal antibody in a protocol relevant to cadaveric organ transplantation 〔Ｊ〕. Transplantation, 1995; 59(6)∶821.
  5. 5. Takiff H, Novak M, Iwaki Y, et al. Lowdose cyclosporine maintenance therapy after immunosupressive induction in a rat cardiac transplant model 〔Ｊ〕. Transplantation, 1988; 45(2)∶297.
  6. 6. 畢愛華.免疫應(yīng)答(二)免疫耐受.見: 畢愛華主編.醫(yī)學(xué)免疫學(xué) 〔M〕. 第1版. 北京: 人民軍醫(yī)出版社, 1995∶123~129.
  7. 7. Bayle F, Masson D, Zaoul P, et al. Beneficial effect of one HLA haplo or semiidentical transfusion versus three untyped blood units on alloimmunization and acute rejection episodes in first renal allograft recipients 〔Ｊ〕. Transplantation, 1995; 59(5)∶719.
  8. 8. Flye MW, Burton K, Mohanakumar T, et al. Donorspecific transfusions have longterm beneficial effects for human renal allografts 〔Ｊ〕. Transplantation, 1995; 60(12)∶1395.
  9. 9. Van Twuvver E, Mooijaart RJD, Ten Berge IJM, et al. Pretransplantation blood transfusion revisited 〔Ｊ〕. N Eng J Med, 1991; 325(17)∶1210.
  10. 10. Brunson M, Tchervenkov JI, Alexander JW, et al. Enhancement of allograft survival by donorspecific transfusion one day prior to transplant 〔Ｊ〕. Transplantation, 1991; 52(4)∶ 543.
  11. 11. Levy AE, Alexander JW. Administration of intragraft interleukin4 prolongs cardiac allograft survival in rats treated with donorspecific transfusion/cyclosporine 〔Ｊ〕. Transplantation, 1995; 60(5)∶405.