• 第一軍醫(yī)大學(xué)珠江醫(yī)院普外科(廣州 510282);

引用本文： 余文林,黃宗海. 自殺基因治療胃腸道腫瘤的研究進(jìn)展. 中國普外基礎(chǔ)與臨床雜志, 1999, 6(3): 187-189. doi: 復(fù)制

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1. Austin EA, Huber BE. A first step in the development of gene therapy for colorectal carcinoma: cloning, sequencing and expression of Escherichia Coli cytosine deaminase. Molecular Pharmecology, 1993; 43(3)∶380.
2. Caruso M, Panis Y, Gagandeep S, et al. Regression of established macroscopic liver metastasis after in situtransduction of a suicide gene. PNAS, 1993; 90(15)∶7024.
3. Yoshida K, Kawami H, Yamaguchi Y, et al. Retrovirally transmitted gene therapy for gastric carcinoma using herpes simplex virus thymidine kinase gene. Cancer, 1995; 75(6)∶1467.
4. Huber BE, Austin EA, Good SS, et al. In vivo antitumor activity of 5Fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase. Cancer Res, 1993; 53(19)∶4619.
5. Tanaka T, Kanai F, Lan KH, et al. Adenovirusmediated gene therapy of gastric carcinoma using cancerspecific gene expression in vivo. Biochem Biophys Res Commun, 1997; 231(3)∶775.
6. Hirschowitz EA, Ohwada A, Pascal WR. In vivo adenovirus mediated gene transfer of the Escherichia Coli cytosine deaminase gene to human colon carcinomaderived tumors induce chemosensitivity to 5Fluorocytosine. Human Gene Ther, 1995; 6(8)∶1055.
7. Huber BE, Richardi CA, Austin EA. Virusdirected enzyme/prodrug therapy (VDEPT), selectively engineering drug sensitivity into tumors. Ann N Y Acad Sci, 1994; 716(1)∶104.
8. Richards CA, Austin EA, Huber BE. Transcriptional regulatory sequences of carcinoembryonic antigen: identification and use with cytosine deaminase for tumor specific gene therapy. Hum Gene Ther, 1995; 6(7)∶881.
9. Tanaka T, Kanai F, Okabe S, et al. Adenovirusmediated prodrug gene therapy for carcinoembryonic antigenproducing human gastric carcinoma cells in vitro. Cancer Res, 1996; 56(6)∶1341.
10. lan KH, Kanai F, Shiratori Y, et al. Tumorspecific gene expression in carcinoembryonic antigenproducing gastric cancer cells using adenovirus vectors. Gastroenterology, 1996; 111(5)∶1241.
11. 崔龍， 曹廣文， 王元和等. HSVTK基因體外特異性前藥轉(zhuǎn)換抗大腸癌作用研究. 中華外科雜志， 1997； 35(6)∶356.
12. Huber BE, Austin EA, Richards CA, et al. Metabolism of 5Fluorocytosine to 5flurouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. PANS, 1994; 91(17)∶8302.
13. Freeman SM, Abboud CN, Whartenby KA, et al. The “bystander effect": tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res, 1993; 53(22)∶5274.
14. Mesnil M, Piccoli C, Tiraby G, et al. Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is medicated by connexins. PNAS, 1996; 93(5)∶1831.
15. Christopher CA, Nielsen MD, Donald W, et al. Herpes simplex thymidine kinase gene therapy is required for complete regression of murine colon adenocarcinoma. Am Surg, 1997; 63(7)∶617.
16. Mullen CA, Petropoulos D, Lowe RM, et al. Treatment of microscopic pulmonary metastasis with recombinant autologous tumor vaccine expressing interleukin6 and Escherichia Coli cytosine deaminase suicide gene. Cancer Res, 1996; 56(6)∶1361.
17. Chen SH, Chen L, Wang YB, et al. Combination gene therapy for metastasis of colon carcinoma in vivo. Proc Natl Acad Sci USA, 1995; 92(7)∶2577.
18. Chen SH, Kosai K, Xu B, et al. Combination suicide and cytokine gene therapy for hepatic metastasis of colon carcinoma: sustained antitumor immunity prolongs animal survival. Cancer Res, 1996; 56(16)∶3758.
  1. 1. Austin EA, Huber BE. A first step in the development of gene therapy for colorectal carcinoma: cloning, sequencing and expression of Escherichia Coli cytosine deaminase. Molecular Pharmecology, 1993; 43(3)∶380.
  2. 2. Caruso M, Panis Y, Gagandeep S, et al. Regression of established macroscopic liver metastasis after in situtransduction of a suicide gene. PNAS, 1993; 90(15)∶7024.
  3. 3. Yoshida K, Kawami H, Yamaguchi Y, et al. Retrovirally transmitted gene therapy for gastric carcinoma using herpes simplex virus thymidine kinase gene. Cancer, 1995; 75(6)∶1467.
  4. 4. Huber BE, Austin EA, Good SS, et al. In vivo antitumor activity of 5Fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase. Cancer Res, 1993; 53(19)∶4619.
  5. 5. Tanaka T, Kanai F, Lan KH, et al. Adenovirusmediated gene therapy of gastric carcinoma using cancerspecific gene expression in vivo. Biochem Biophys Res Commun, 1997; 231(3)∶775.
  6. 6. Hirschowitz EA, Ohwada A, Pascal WR. In vivo adenovirus mediated gene transfer of the Escherichia Coli cytosine deaminase gene to human colon carcinomaderived tumors induce chemosensitivity to 5Fluorocytosine. Human Gene Ther, 1995; 6(8)∶1055.
  7. 7. Huber BE, Richardi CA, Austin EA. Virusdirected enzyme/prodrug therapy (VDEPT), selectively engineering drug sensitivity into tumors. Ann N Y Acad Sci, 1994; 716(1)∶104.
  8. 8. Richards CA, Austin EA, Huber BE. Transcriptional regulatory sequences of carcinoembryonic antigen: identification and use with cytosine deaminase for tumor specific gene therapy. Hum Gene Ther, 1995; 6(7)∶881.
  9. 9. Tanaka T, Kanai F, Okabe S, et al. Adenovirusmediated prodrug gene therapy for carcinoembryonic antigenproducing human gastric carcinoma cells in vitro. Cancer Res, 1996; 56(6)∶1341.
  10. 10. lan KH, Kanai F, Shiratori Y, et al. Tumorspecific gene expression in carcinoembryonic antigenproducing gastric cancer cells using adenovirus vectors. Gastroenterology, 1996; 111(5)∶1241.
  11. 11. 崔龍， 曹廣文， 王元和等. HSVTK基因體外特異性前藥轉(zhuǎn)換抗大腸癌作用研究. 中華外科雜志， 1997； 35(6)∶356.
  12. 12. Huber BE, Austin EA, Richards CA, et al. Metabolism of 5Fluorocytosine to 5flurouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. PANS, 1994; 91(17)∶8302.
  13. 13. Freeman SM, Abboud CN, Whartenby KA, et al. The “bystander effect": tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res, 1993; 53(22)∶5274.
  14. 14. Mesnil M, Piccoli C, Tiraby G, et al. Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is medicated by connexins. PNAS, 1996; 93(5)∶1831.
  15. 15. Christopher CA, Nielsen MD, Donald W, et al. Herpes simplex thymidine kinase gene therapy is required for complete regression of murine colon adenocarcinoma. Am Surg, 1997; 63(7)∶617.
  16. 16. Mullen CA, Petropoulos D, Lowe RM, et al. Treatment of microscopic pulmonary metastasis with recombinant autologous tumor vaccine expressing interleukin6 and Escherichia Coli cytosine deaminase suicide gene. Cancer Res, 1996; 56(6)∶1361.
  17. 17. Chen SH, Chen L, Wang YB, et al. Combination gene therapy for metastasis of colon carcinoma in vivo. Proc Natl Acad Sci USA, 1995; 92(7)∶2577.
  18. 18. Chen SH, Kosai K, Xu B, et al. Combination suicide and cytokine gene therapy for hepatic metastasis of colon carcinoma: sustained antitumor immunity prolongs animal survival. Cancer Res, 1996; 56(16)∶3758.